Abstract:Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) negatively regulates protein translation through the phosphorylation of its specific substrate, eEF2. We
previously found that expression of eEF2K was increased in arteries from 13–15-week-old spontaneously hypertensive rats (SHR) as well as in left ventricles of
cardiac hypertrophy models. Furthermore, we demonstrated that eEF2K mediates the development of essential hypertension and pulmonary arterial hypertension in
animal models. Protein expression change… Show more
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