Age-Dependent Effect of Left Ventricular Ejection Fraction on Long-Term Mortality in Patients With Heart Failure (from the Heart Failure Survey in ISrael)

Koifman, Edward; Kopel, Eran; Medvedovsky, Diego; Maor, Elad; Hamdan, Ashraf; Goldenberg, Ilan; Klempfner, Robert

doi:10.1016/j.amjcard.2013.08.015

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…18,25 Furthermore, standard treatment evidence that promises reduction in morbidity and mortality among patients with HFPEF is not well established yet. 24 Although, in our series preadmission medications were comparable between the 2 groups, on admission and at discharge patients with HFREF were prescribed evidence-based medication more frequently than patients with HFPEF. In I-PREFER study, the HFPEF group had a greater prescription rate of calcium channel blockers and ARBs but ACEI, bblockers, and diuretics were prescribed significantly more often in patients with HFREF.…”

Section: Discussioncontrasting

confidence: 49%

“…14 –22 However, recent studies showed the hospitalization rate for HFPEF to be 30% to 34%. 23,24 These estimate variations largely attribute to the diversity in LVEF cutoff criteria used in different registries which ranged from >40%, >45%, >50%, and ≥55%. 25 Also, some studies considered inpatient and others included outpatient data as the study population.…”

Section: Discussionmentioning

confidence: 99%

“…18,25 Furthermore, standard treatment evidence that promises reduction in morbidity and mortality among patients with HFPEF is not well established yet. 24…”

Section: Discussionmentioning

confidence: 99%

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Congestive Heart Failure With Apparently Preserved Left Ventricular Systolic Function

et al. 2014

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We analyzed the clinical presentation and outcomes (from 2003 to 2013) of heart failure (HF) with apparently normal systolic function (HFPEF). Based on the echocardiographic left ventricular ejection fraction (LVEF), patients were divided into 2 groups, group 1 (<50%) and group 2 (≥50%). Of 2212 patients with HF, 20% were in group 2. Patients in group 2 were more likely to be older, females, Arabs, hypertensive, and obese (P = .001). Patients in group 1 were mostly Asians and had more troponin-T positivity (P = .001). Inhospital cardiac arrest, shock, and deaths were significantly greater in group 1. On multivariate analysis, age, ST-segment elevation myocardial infarction, lack of on-admission β-blockers, and angiotensin-converting enzyme inhibitors use were independent predictors of mortality. HFPEF is associated with less mortality compared to those who presented with reduced LVEF. On admission, use of evidence-based medications could in part predict this difference in the hospital outcome.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Congestive Heart Failure With Apparently Preserved Left Ventricular Systolic Function

et al. 2014

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“…It is interesting to note that, when analysed according to EF thresholds of 45–49% vs. 50–54% vs. ≥55% in community‐based studies, the overall mean prevalence of HFpEF (4.4% vs. 2.3% vs. 3.9%, respectively, and HFpEF as a percentage of all HF (43% vs. 53% vs. 73%, respectively) did not display clear trends. Similarly, when comparing HFpEF prevalence based on EF thresholds of 40–44% vs. 45–49% vs. 50–54% in registry studies, no clear trend was identified in HFpEF as a percentage of all HF (41% vs. 36% vs. 47%) …”

Section: Resultsmentioning

confidence: 97%

Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review

Vaduganathan

Michel

Hall

et al. 2015

European J of Heart Fail

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“…The characteristics of patients admitted to cardiology wards with a primary diagnosis of HF have been described in many surveys . However, the large proportion of patients with a primary diagnosis of HF who are admitted under the care of general physicians or geriatricians are much less well represented.…”

Section: Discussionmentioning

confidence: 99%

Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey‐1

Shoaib

Farag

Nasir

et al. 2016

European J of Heart Fail

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Aims Most studies on acute heart failure (HF) exploring the relationship between admissions to hospital for HF and subsequent outcomes have focused only on HF coded as the primary diagnosis, but many other patients have admissions complicated by HF requiring attention. Failure to quantify the total hospital burden of HF underestimates its health economic impact, leading to underprovision of resources for its care. Methods and results The First Euro Heart Failure Survey (EHFS-1) screened consecutive deaths and discharges, regardless of cause, from medical wards in 115 hospitals from 24 European countries during 2000–2001, to identify patients with known or suspected HF. Information on presenting symptoms and signs were gathered. Of 10 701 patients enrolled, HF was reported as the primary reason for admission in 4234 (40%), a secondary reason for admission if it complicated or prolonged stay in 1772 (17%), and in 4695 (43%) patients it was uncertain whether HF was actively contributing to the admission. Mortality on the index admission was 301 (7%), 290 (16%), and 189 (4%), respectively, with hazard ratios of 1.73 (P < 0.001) and 3.26 (P < 0.001) compared with the ‘uncertain’ group. In the 12 weeks following discharge, 287 (7%) patients with a primary, 117 (8%) with a secondary, and 238 (5%) with an incidental or uncertain diagnosis of HF died. Conclusion Patients admitted to hospital with HF as a secondary rather than a primary diagnosis have a high mortality. More attention should be focused on patients with a secondary diagnosis of HF in terms of both care and research

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Age-Dependent Effect of Left Ventricular Ejection Fraction on Long-Term Mortality in Patients With Heart Failure (from the Heart Failure Survey in ISrael)

Cited by 4 publications

References 26 publications

Congestive Heart Failure With Apparently Preserved Left Ventricular Systolic Function

Congestive Heart Failure With Apparently Preserved Left Ventricular Systolic Function

Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review

Is the diagnostic coding position of acute heart failure related to mortality? A report from the Euro Heart Failure Survey‐1

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