Age-dependent different action of curcumin in thyroid of rat.

Papież, Monika; Kaja, Marcin; Gebarowska, Agata

doi:10.2478/v10042-008-0031-6

Cited by 19 publications

(18 citation statements)

References 32 publications

(35 reference statements)

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“…This was substantiated by morphometric analysis of follicular diameter, height of follicular cells and area percent of colloid which revealed non significant differences as compared to control group. These findings were consistent with the assumption that curcumin activity depends on the functional condition of the gland [20] .…”

Section: Discussionsupporting

confidence: 91%

“…It was purchased from Sigma-Aldrich chemical company (Cairo, Egypt) in the form of a bottle containing 10 gm of yellow powder, (Catalogue number C1386). The required daily dose (for the 5 rats of the group) was weighted, suspended in 2 ml corn oil and given orally through gastric gavage at a dose of 100 mg/Kg/bw [20] .…”

Section: -Curcuminmentioning

confidence: 99%

“…-Group II (curcumin group): (n= 5), rats were given curcumin orally through gastric gavage at a dose of 100 mg /kg/bw, dissolved in 2 ml corn oil daily for 4 weeks then sacrificed [20] .…”

Section: C) Experimental Designmentioning

confidence: 99%

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Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats

Aboul-Fotouh

El-Nour

Farag

et al. 2018

Egyptian Journal of Histology

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Introduction: Potassium dichromate, a widely used heavy metal in several industries induces hypofunction and tissue insult of the thyroid gland via oxidative stress. Curcumin; is a natural commonly used spice has a strong anti-inflammatory and antioxidant properties. Aim of the work: To investigate the possible protective effect of curcumin on the hypothyroidism induced by potassium dichromate in albino rats. Materials and Methods: Thirty-five adult male albino rats were divided into five groups, 15 rats in group I (control) and 5 rats in each of group II, III, IV and V. Group II (curcumin group) received curcumin orally (100 mg /kg/bw) daily for 4 weeks. Group III (potassium dichromate induced hypothyroidism) received i.p injection of potassium dichromate (2 mg/kg/ bw) daily for 2 weeks. Group IV (recovery group) received potassium dichromate as group III then left untreated for another 2 weeks. Group V(curcumin and potassium dichromate group) received curcumin concomitant with potassium dichromate as in groups II and III, respectively daily for 2 weeks and only curcumin was continued for another 2 weeks. T3, T4 and TSH were assessed. Thyroid sections were subjected to toluidine blue, H&E, PAS and PCNA immunohistochemical stains. Morphometric and statistical studies were done. Results: Thyroid tissue insult and hypofunction with significantly decreased T3, T4 and increased TSH were detected in group III. Additionally, there was a significant increase in the mean values of follicular cell height, follicular diameter, mean number of PCNA positive nuclei and a significant decrease in the mean value of area percent of colloid versus group I, II and V with non-significant differences versus group IV. In group V, there was an obvious serological and histological improvement compared to group III and IV. Conclusion: Curcumin had protective effect against hypothyroidism and thyroid tissue damage induced by potassium dichromate.

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Section: Discussionsupporting

confidence: 91%

Section: -Curcuminmentioning

confidence: 99%

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Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats

Aboul-Fotouh

El-Nour

Farag

et al. 2018

Egyptian Journal of Histology

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“…While many studies have reported on the variety of beneficial effects of polyphenols there is also evidence to suggest that there are age-related differences in the effectiveness of these compounds in the treatment of model dysfunctions [69]. In addition, in vitro analyses by many investigators have shown that compounds like resveratrol have the capacity to significantly affect the cellular environment even at low concentrations while others suggest that polyphenols may possess cytotoxic effects under certain conditions [70].…”

Section: Polyphenols Activate Important Cell Regulatory Proteinsmentioning

confidence: 99%

Polyphenols and Aging

Queen¹,

Tollefsbol²

2010

CAS

163

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Age-associated changes within an individual are inherently complex and occur at multiple levels of organismal function. The overall decline in function of various tissues is known to play a key role in both aging and the complex etiology of certain age-associated diseases such as Alzheimer’s disease (AD) and cancer. Continuing research highlights the dynamic capacity of polyphenols to protect against age-associated disorders through a variety of important mechanisms. Numerous lines of evidence suggest that dietary polyphenols such as resveratrol, (−)-epigallocatechin-3-gallate (EGCG), and curcumin have the capacity to mitigate age-associated cellular damage induced via metabolic production of reactive oxygen species (ROS). However, recently acquired evidence also demonstrates a likely role for these polyphenols as anticancer agents capable of preventing formation of new vasculature in neoplastic tissues. Polyphenols have also been shown to possess other anticancer properties such as specific cell-signaling actions that may stimulate the activity of the regulatory protein SIRT1. Additionally, polyphenolic compounds have demonstrated their inhibitory effects against chronic vascular inflammation associated with atherosclerosis. These increasingly well-documented results have begun to provide a basis for considering the use of polyphenols in the development of novel therapies for certain human diseases. And while the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases.

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“…Up to now no studies have reported the effects of Cuminum cyminum seeds on broiler blood thyroid hormones whether in thermoneutral or heat stress conditions. Also, limited numbers of animal studies on the effects of some feeding spice products and medicinal herbs acting as an antioxidant on thyroid hormones were reported and discrepant results were obtained [48,49] . The supplementation of broiler chicken's diet with Cuminum cyminum seeds at a level of 0.2% enhanced broiler feed efficacy during the summer and concomitantly, alleviated the negative effects of chronic heat stress on glycaemia, lipidaemia and calcaemia of broilers.…”

Section: Berrama Temim Souames Ainbazizmentioning

confidence: 99%

Kimyon (Cuminum cyminum L.) Çekirdeği ile Beslenen ve Kronik Isı Stresine Maruz Bırakılan Broiler tavuklarda Büyüme Performansı, Karkas ve Visseral Organ Ağırlıkları, Kan Bileşenleri ve Tiroit Hormon Konsantrasyonları

Berrama¹,

Temim²,

Souames³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleBerrama Z, Temim S, Souames S, Ainbaziz H: Growth performance, carcass and viscera yields, blood constituents and thyroid hormone concentrations of chronic heat stressed broilers fed diets supplemented with cumin seeds (Cuminum cyminum L.). Kafkas Univ Vet Fak Derg, 23 (5): 735-742, 2017735-742, . DOI: 10.9775/kvfd.2017 AbstractThis study was conducted to determine the effect of dietary supplementation with cumin (Cuminum cyminum L.) seeds on growth performances, relative weights of carcass and viscera, haematological and biochemical parameters, and thyroid hormones concentrations of broiler chickens subjected to natural fluctuation of Algerian summer ambient temperatures. A total of 440 28-day old chickens were divided into 2 groups (5 replicates of 44 birds) with similar body weight (971±48 g): a "Control" group fed with a standard diet and a "Cumin" group receiving a basal diet supplemented with 0.2% of cumin. As a result of this study, dietary cumin supplementation did not significantly modify the growth rate and final body weights of heat-exposed chickens but it slightly improved feed conversion ratio (-7%, P=0.1). Carcass traits, viscera (liver, heart, gizzard, spleen, bursa and thymus) intestine morphology and abdominal fat of heat stressed birds did not reveal any changes by cumin inclusion compared to the control ones. Also, thyroid hormones (T3 and T4) concentrations were not significantly influenced by dietary cumin (P>0.05). However, heat-exposed chickens supplemented with cumin exhibited a significant (P<0.01) lower values of plasma glucose, cholesterol, triglycerides and total proteins and higher calcium concentrations than those of control group. Cumin dietary may be a successful means to enhancing diet conversion and reducing glaecimic, lipidaemic and calcaemic disorders in chronicallyheat exposed chickens. Keywords: Blood parameters, Broilers, Carcass, Chronic heat stress, Climate, Cuminum cyminum, Performance, Thyroid hormones Kimyon (Cuminum cyminum L.) Çekirdeği İle Beslenen ve Kronik Isı Stresine Maruz Bırakılan Broiler Tavuklarda Büyüme Performansı, Karkas ve Visseral Organ Ağırlıkları, Kan Bileşenleri ve Tiroit Hormon Konsantrasyonları ÖzetBu çalışma, Cezayir'de yaz çevre ısısının doğal dalgalanmasına maruz kalan broiler tavuklarda yeme kimyon (Cuminum cyminum L.) çekirdeği ilavesinin büyüme performansına, karkas ve vissera ağırlığı oranına, kan ve biyokimyasal parametrelere ve tiroit hormon konsantrasyonuna etkilerini belirlemek amacıyla yapıldı. Toplam 440 adet 28 günlük tavuklar vücut ağırlıkları (971±48 g) benzer olmak üzere 2 gruba (44 tavuk, 5 tekrar olarak) ayrıldı. "Kontrol grubu" standart diyet ile beslenirken, "Kimyon grubuna" % 0.2 oranında kimyon ilave edilmiş bazal diyet verildi. Elde edilen sonuçlar ısı stresine maruz kalan broiler tavuklarda diyetsel kimyon ilavesinin büyüme oranına ve nihai vücut ağırlığına önemli bir etki yapmadığını fakat az oranda yem konversiyon oranına (% -7, P=0.1) etki ettiğini gösterdi. karkas özellikleri, visseral organ (k...

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Age-dependent different action of curcumin in thyroid of rat.

Cited by 19 publications

References 32 publications

Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats

Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats

Polyphenols and Aging

Kimyon (Cuminum cyminum L.) Çekirdeği ile Beslenen ve Kronik Isı Stresine Maruz Bırakılan Broiler tavuklarda Büyüme Performansı, Karkas ve Visseral Organ Ağırlıkları, Kan Bileşenleri ve Tiroit Hormon Konsantrasyonları

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