Age-Dependent Differences in Human Brain Activity Using a Face- and Location-Matching Task: An fMRI Study

Leinsinger, Gerda; Born, Christine; Meindl, Thomas; Bokde, Arun L.W.; Britsch, Stefan; Lopez-Bayo, Patricia; Teipel, Stefan J.; Möller, Hans‐Jürgen; Hampel, Harald; Reiser, Maximilian

doi:10.1159/000107098

Cited by 7 publications

(4 citation statements)

References 49 publications

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“…Advanced neuroimaging techniques provide promising avenues to verify the neural correlates of the declined face processing in old adults. Evidence from studies using task‐fMRI techniques have shown that the cognitive declines of face processing may be related to reduced neural selectivity (Koen & Rugg, 2019; Leinsinger et al, 2007; Reuter‐Lorenz & Park, 2010). Specifically, it is characterized by the reduced neural response to faces relative to other control stimuli in the fusiform face area (FFA) and the occipital face area (OFA; Goh et al, 2010; Lee et al, 2011; D. C. Park et al, 2004; J.…”

Section: Introductionmentioning

confidence: 99%

“…Evidence from studies using task-fMRI techniques have shown that the cognitive declines of face processing may be related to reduced neural selectivity Tianying Qing and Jing Chen contributed equally to this article. (Koen & Rugg, 2019;Leinsinger et al, 2007;Reuter-Lorenz & Park, 2010). Specifically, it is characterized by the reduced neural response to faces relative to other control stimuli in the fusiform face area (FFA) and the occipital face area (OFA; Goh et al, 2010;Lee et al, 2011;D.…”

Section: Introductionmentioning

confidence: 99%

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Decreasing integration within face network and segregation beyond the face network in the aging brain

et al. 2022

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Face processing is known to decline in older adults; however, a clear understanding of the brain networks behind this cognitive decline is still lacking. In this study, we investigated the neural correlates of the declined face processing with aging from a resting‐state brain network perspective. Nineteen healthy old adults and 22 young adults were recruited and underwent two functional magnetic resonance imaging (fMRI) scanning sessions (i.e., resting‐state and localizer task) and two behavioral tests (face matching and symbol‐form matching). We examined age‐related alterations in resting‐state functional connectivity (FC) within face network as well as between face network and other networks, and tested their associations with behavioral performance of face and symbol‐form processing. We found that (a) compared with young adults, old adults exhibited decreased FC between face‐selective regions (fusiform face area and occipital face area), but increased FC between face‐selective regions and non‐face‐selective regions; (b) these age‐related FC alterations were correlated with individuals’ behavioral performance of face and symbol‐form processing. Collectively, these findings suggest the declines of face processing are associated with a mixture of decreased integration within the face network and segregation beyond the face network in the aging brain, and provide evidence for a neural basis of cognitive aging in face processing from an intrinsic brain network perspective.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decreasing integration within face network and segregation beyond the face network in the aging brain

et al. 2022

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“…The main brain areas showing activation in response to such visuospatial tasks include the medial (including paracentral lobule and precuneus) [3,22,23] and dorsal parietal cortex (BA 7) [24] ; temporoparieto-occipital cortex [10,[25][26][27][28] ; frontal regions, including medial frontal, cingulate [22,28] and medial and lateral premotor cortices [29] . Few neuroimaging trials have examined the effects of AChEI treatment.…”

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confidence: 99%

Treatment Effects of Therapeutic Cholinesterase Inhibitors on Visuospatial Processing in Alzheimer’s Disease: A Longitudinal Functional MRI Study

Thiyagesh

Farrow²,

Parks³

et al. 2010

Dement Geriatr Cogn Disord

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Background/Aims: Visuospatial impairments are known to occur in Alzheimer’s disease (AD). We hypothesised that functional magnetic resonance imaging (fMRI) response in task-related brain regions would be impaired in patients with AD during the task and that treatment with acetyl cholinesterase inhibitors would enhance activations in brain regions concerned with this visual perceptual processing. Method: Ten AD subjects were neuropsychologically assessed and underwent fMRI imaging whilst performing a series of visuospatial perception tasks, before and after treatment with acetyl cholinesterase inhibitors. Eleven healthy elderly comparison subjects were also scanned twice. Results: Regions of increased brain activation in AD included the left precuneus, left cuneus, left supramarginal gyrus, right parieto-temporal cortex and right inferior parietal lobule. Further, increased activation in the left precuneus was found to correlate significantly with improved functioning of activities of daily living. Conclusions: We believe this to be the first fMRI study that, after controlling for the confound of repeat scanning, demonstrates altered patterns of brain activation associated with visuospatial processing following treatment in patients with AD. The treatment-related improvement of visual perception in AD may rely on enhanced attentional mechanisms, thereby possibly supporting independent living through improvement on activities of daily living.

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“…Cropping the image to an oval shape that reveals only these features ensures that face recognition concentrates on these essential facial features. Moreover, a more or less oval mask has proven to be appropriate in previous research (e.g., Bokde et al, 2005;Leinsinger et al, 2007;White & Li, 2006).…”

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confidence: 99%

The use of faces as stimuli in neuroimaging and psychological experiments: A procedure to standardize stimulus features

Gronenschild¹,

Smeets²,

Vuurman³

et al. 2009

Behavior Research Methods

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In psychological experiments involving facial stimuli, it is of great importance that the basic perceptual or psychological characteristics that are investigated are not confounded by factors such as brightness and contrast, head size, hair cut and color, skin color, and the presence of glasses and earrings. Standardization of facial stimulus materials reduces the effect of these confounding factors. We therefore employed a set of basic image processing techniques to deal with this issue. The processed images depict the faces in grayscale, all at the same size, brightness, and contrast, and confined to an oval mask revealing only the basic features such as the eyes, nose, and mouth. The standardization was successfully applied to four different face databases, consisting of male and female faces and including neutral as well as happy facial expressions. An important advantage of the proposed standardization is that featural as well as configurational information is retained. We also consider the procedure to be a major contribution to the development of a de facto standard for the use of facial stimuli in psychological experiments. Such methodological standardization would allow a better comparison of the results of these studies.

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Age-Dependent Differences in Human Brain Activity Using a Face- and Location-Matching Task: An fMRI Study

Cited by 7 publications

References 49 publications

Decreasing integration within face network and segregation beyond the face network in the aging brain

Decreasing integration within face network and segregation beyond the face network in the aging brain

Treatment Effects of Therapeutic Cholinesterase Inhibitors on Visuospatial Processing in Alzheimer’s Disease: A Longitudinal Functional MRI Study

The use of faces as stimuli in neuroimaging and psychological experiments: A procedure to standardize stimulus features

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