Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

Grell, S. N.; Riber, Ulla; Tjørnehøj, Kirsten; Larsen, Lars Erik; Heegaard, Peter M. H.

doi:10.1016/j.vaccine.2005.01.094

Cited by 20 publications

(32 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study in which antibodies to human influenza A virus protected cells from streptococcal adherence [34] further supports the hypothesis that early and sufficient production of antibodies to the virus may have protected calves from exacerbated bacterial infection. However, T-cell responses [35] along with the production of specific IgG 2 , IgA and virusneutralizing antibodies [36] also have important roles in immune response to BRSV infection, and we cannot argue solely in favour of specific IgG 1 production since we have not measured other immune functions.…”

Section: Discussionmentioning

confidence: 95%

Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus

Orro

Pohjanvirta

Rikula

et al. 2011

Comparative Immunology, Microbiology and Infectious Diseases

View full text Add to dashboard Cite

Bovine acute phase proteins (APPs), lipopolysaccharide binding protein (LBP), serum amyloid A (SAA), haptoglobin (Hp) and alpha(1)-acid glycoprotein (AGP) were evaluated as inflammatory markers during an outbreak of bovine respiratory disease (BRD) caused by bovine respiratory syncytial virus (BRSV). Calves (n = 10) presented mild to moderate signs of respiratory disease. Secondary bacterial infections, Pasteurella multocida and Mycoplasma dispar as major species, were detected in tracheobronchial lavage samples. Concentrations of SAA and LBP increased at week 1 had the highest values at week 3 and decreased at week 4 of outbreak. Some calves had high Hp concentrations at week 3, but AGP concentrations did not rise during respiratory disease. Higher SAA, LBP and Hp concentrations at a later stage of BRD (week 3) were associated with the low BRSV-specific IgG(1) production, suggesting that these calves had enhanced inflammatory response to the secondary bacterial infection. In conclusion, APPs (especially SAA and LBP) are sensitive markers of respiratory infection, and they may be useful to explore host response to the respiratory infections in clinical research.

show abstract

Section: Discussionmentioning

confidence: 95%

Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus

Orro

Pohjanvirta

Rikula

et al. 2011

Comparative Immunology, Microbiology and Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Most importantly, there is a similar age dependency in the development of bRSV disease: more severe LRTD occurs in young calves, whereas neonatal infection follows a nonspecific pattern of disease (4,52,111). bRSV infection in calves causes overt clinical signs of URTD and LRTD (peak at day 7 after experimental inoculation), such as nasal discharge, cough, tachypnea with chest retractions, wheezing, hypercapnia, and hypoxemia (4,6,25,49,52,111,115). General symptoms, including fever, anorexia, and reduced activity, are also observed.…”

Section: Cognate Host-pneumovirus Modelsmentioning

confidence: 99%

Animal models of human respiratory syncytial virus disease

Reinout

Domachowske

Rosenberg

2011

American Journal of Physiology-Lung Cellular and Molecular Phys

173

228

View full text Add to dashboard Cite

Bem RA, Domachowske JB, Rosenberg HF. Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol 301: L148 -L156, 2011. First published May 13, 2011; doi:10.1152/ajplung.00065.2011.-Infection with the human pneumovirus pathogen, respiratory syncytial virus (hRSV), causes a wide spectrum of respiratory disease, notably among infants and the elderly. Laboratory animal studies permit detailed experimental modeling of hRSV disease and are therefore indispensable in the search for novel therapies and preventative strategies. Present animal models include several target species for hRSV, including chimpanzees, cattle, sheep, cotton rats, and mice, as well as alternative animal pneumovirus models, such as bovine RSV and pneumonia virus of mice. These diverse animal models reproduce different features of hRSV disease, and their utilization should therefore be based on the scientific hypothesis under investigation. The purpose of this review is to summarize the strengths and limitations of each of these animal models. Our intent is to provide a resource for investigators and an impetus for future research. respiratory virus; pneumovirus; rodent; inflammation Human RSV Disease: Why Model?Human respiratory syncytial virus (hRSV) is among the most important respiratory pathogens in young children worldwide. hRSV infection and transmission result in community outbreaks with peak activity during the winter months in areas with temperate climates, whereas hRSV disease activity is observed on a more continuous basis throughout the year in tropical regions (119). In a recent evaluation of the global burden of hRSV-associated acute lower respiratory tract disease (LRTD), Nair and colleagues (82) noted that, each year, over 33 million children under the age of 5 yr are affected by this disease, leading to over 3 million hospitalizations and almost 200,000 deaths. The annual costs of health care associated with hRSV infection among children in the US alone are over $600 million (86). In addition, a growing body of evidence suggests that hRSV infection results in substantial morbidity among the elderly and in adults with underlying chronic illnesses, further highlighting both the healthcare-related and economic burden of hRSV disease (44).At this writing, there is no licensed vaccine for hRSV, and there are no specific treatment options for severe disease. There is presently no clear evidence supporting the routine use of the antiviral ribavirin (114), inhaled or systemic corticosteroids (12, 87), or bronchodilators (47) as mainstays of acute therapy in nonimmunosuppressed infants and children. The humanized monoclonal anti-RSV F protein, palivizumab, is approved for prophylactic use in high-risk infants only (41, 72), and thus this modality does not presently address the burden of disease among those with no apparent risk factors (55).Modeling human hRSV disease in vivo is an indispensable step in the search for novel therapies and preventive measures for hRSV disease. Animal models provide for t...

show abstract

“…In dairy calves, maternal antibodies to BRSV have been documented until, on average, 3.3 months of age, up to a maximum of 7 months (Baker et al. 1986; Grell et al. 2005).…”

Section: Discussionmentioning

confidence: 99%

“…2002), the most severe disease being observed in calves <6 months of age (van der Poel et al. 1994; Grell et al. 2005).…”

Section: Introductionmentioning

confidence: 99%

Acute BRSV Infection in Young AI Bulls: Effect on Sperm Quality

Alm

Koskinen

Vahtiala

et al. 2009

Reprod Domestic Animals

View full text Add to dashboard Cite

Bovine respiratory syncytial virus (BRSV) infection is an important part of the calf pneumonia complex, occasionally affecting even adult cattle. However, the pathogenicity of BRSV in animals older than 6 months is often neglected. Finland is free of many contagious diseases in farm animals, and this gives a good opportunity to study the effects of specific pathogens on bovine reproduction. This report describes the deteriorating effects of BRSV epizootics on sperm morphology and fertility of young dairy bulls (n = 79) at a bull station. More than half of the young bulls had a clinical respiratory disease caused by BRSV during their quarantine when they were 6 months old. Four of seven subsequent quarantine groups were affected. Six months later, when these seropositive bulls (n = 54) came into semen production, they had poorer sperm morphology, and the proportion of normal spermatozoa was 74.1% in BRSV-seropositive animals compared with 81.2% in seronegative bulls (n = 25) (p = 0.035). Field fertility was also slightly affected, the 60-day non-return rates were 75.2% and 76.8% for BRSV seropositive and seronegative bulls respectively (p = 0.014). Potential reasons for lowered sperm quality are discussed here.

show abstract

Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

Cited by 20 publications

References 52 publications

Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus

Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus

Animal models of human respiratory syncytial virus disease

Acute BRSV Infection in Young AI Bulls: Effect on Sperm Quality

Contact Info

Product

Resources

About