Age-dependent decrease of the passive Rb+ and K+ permeability of the nerve cell membranes in rat brain cortex as revealed by in vivo measurement of the Rb+ discrimination ratio

Gyenes, M.; Lustyik, György; Zs.-Nagy, Valéria; Jeney, Florence; Zs.‐Nagy, Imre

doi:10.1016/0167-4943(84)90012-8

Cited by 19 publications

(2 citation statements)

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“…A number of investigators impute a role for the cellular and subcellular membranes in the etiology of aging [4,6,22]. Progeria is regarded as a model of aging [13]; fibroblasts from progeroid individuals have shown a sharply reduced population doubling poten tial [8].…”

Section: Discussionmentioning

confidence: 99%

Cell Membrane Transport Enzymes in Cultured Dermal Fibroblasts from Progeroid Donors: A Comparison to Other Human Fibroblasts

Mokrasch¹

1986

Gerontology

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Cell membranes from progeroid fibroblasts had an elevated Na⁺, K⁺ ATPase. Ca⁺⁺ ATPase and γ-glutamyl transpeptidase were markedly decreased in progeroid fibroblast membranes. 5′-nucleotide phosphatase was unchanged, compared to age- and sex-matched normal fibroblast membranes. Fetal lung fibroblasts and dermal fibroblast from myotonic dystrophy victims had enzyme activities similar to those of the normal dermal fibroblasts.

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Section: Discussionmentioning

confidence: 99%

Cell Membrane Transport Enzymes in Cultured Dermal Fibroblasts from Progeroid Donors: A Comparison to Other Human Fibroblasts

Mokrasch¹

1986

Gerontology

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“…Within the nervous system of aged animals, altered functioning of various components of the plasma membrane has been described. These include changes in membrane rigidity (10,11), neurotransmitter-related receptor sites (1,13), and ion transport systems (5). We have compared levels of ionic calcium in a crude synaptosomal fraction from 3-and 26-month-old mice.…”

Section: Introductionmentioning

confidence: 99%

Increased fragility of neuronal membranes with aging

Bondy

1989

Experimental Neurology

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Changes in membrane integrity have been implicated as a contributing factor in the aging process. We have examined the relative stability of synaptosomal membranes from young and aged mice, in response to chemically induced damage. The basal characteristics of the resting synaptosomes prepared from mice of either age were indistinguishable, as judged by intracellular levels of ionic calcium and by efflux of the fluorescent probe employed, fura-2. However, the response of isolated nerve endings to the presence of a neurotoxic agent, the insecticide chlordecone, was markedly different. Exposure to this chemical invariably elevated free calcium and increased the rate of leakage of fura-2 into the extracellular space. These effects were much more pronounced in preparations derived from aged animals. The implication of these findings is that neural membranes of aged animals are more susceptible to malfunction induced by xenobiotic agents and are less able to maintain homeostasis under such circumstances.

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The membrane hypothesis of aging: its relevance to recent progress in genetic research

Zs-Nagy

1997

J Mol Med

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This review outlines the main concepts of the membrane hypothesis of aging (MHA) developed over the past two decades. MHA offers a general cell biological mechanism to explain the main trends of age-dependent changes in terms of intracellular physicochemistry. An essential point in MHA is that the inevitable plasma membrane alterations result in the accumulation of dry mass in the intracellular space, a process that is essential to cellular development and organismal maturation, but which becomes a rate limiting factor above a certain physical density of the cell colloids. The main statements of the MHA are supported by recent developments in molecular genetics. Specifically, the great majority of the products of oncogenes and antioncogenes are localized to the plasma membrane, indicating a central role of the plasma membrane in mitotic regulation, cell differentiation and senescence.

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Age-dependent decrease of the passive Rb+ and K+ permeability of the nerve cell membranes in rat brain cortex as revealed by in vivo measurement of the Rb+ discrimination ratio

Cited by 19 publications

References 46 publications

Cell Membrane Transport Enzymes in Cultured Dermal Fibroblasts from Progeroid Donors: A Comparison to Other Human Fibroblasts

Cell Membrane Transport Enzymes in Cultured Dermal Fibroblasts from Progeroid Donors: A Comparison to Other Human Fibroblasts

Increased fragility of neuronal membranes with aging

The membrane hypothesis of aging: its relevance to recent progress in genetic research

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