Age-dependent decrease in embryo implantation rate after in vitro fertilization

Kooij, R.J. van; Looman, Caspar W.N.; Habbema, J. Dik F.; Dorland, M.; Velde, Egbert R. te

doi:10.1016/s0015-0282(16)58634-8

Cited by 133 publications

(71 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A detailed description of the protocol was published previously (16). In brief, pituitary desensitization was started in the midluteal phase by the administration of leuprolide acetate (Lucrin; Abbott, Hoofddorp, The Netherlands).…”

Section: Treatment Protocolmentioning

confidence: 99%

A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles

Klinkert

Broekmans

Looman

et al. 2004

Fertility and Sterility

102

View full text Add to dashboard Cite

Objective: To calculate the cumulative ongoing pregnancy rate in patients with a poor response in their first IVF cycle. Design: Retrospective cohort study. Setting: In vitro fertilization unit of a university hospital. Patient(s): Two hundred twenty-five women who experienced a poor response in their first IVF or intracytoplasmic sperm injection cycle. These patients were divided into 64 expected (aged Ն41 years and/or elevated FSH level) and 161 unexpected poor responders (aged Ͻ41 years and FSH level not elevated). Intervention(s):In vitro fertilization treatment with a long-suppression protocol with FSH-urofollitropin or recombinant FSH. Main Outcome Measure(s): Cumulative ongoing pregnancy rate. This rate was calculated in two ways to correct for dropouts: pessimistic (zero chance of pregnancy for the dropouts) and optimistic (the same chance for the dropouts as for patients who continued). Result(s):The cumulative ongoing pregnancy rate of women with an unexpected poor response in the first cycle was 37% (pessimistic) to 47% (optimistic) after three cycles. Women with an expected poor response had a cumulative ongoing pregnancy rate of 16% (pessimistic) to 19% (optimistic) after 3 cycles. Sixty-four percent of the unexpected poor responders and 31% of the expected poor responders had a normal response in the second cycle, most of them after receiving a higher dose of gonadotropins. Conclusion(s):Most patients with an unexpected poor response in the first cycle had a normal response in the second cycle, leading to an acceptable cumulative ongoing pregnancy rate after three cycles. Patients with an expected poor response in the first cycle should be advised to withdraw from treatment after the first cycle because of a poor prognosis. (Fertil Steril 2004;81:1247Ϫ53.

show abstract

Section: Treatment Protocolmentioning

confidence: 99%

A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles

Klinkert

Broekmans

Looman

et al. 2004

Fertility and Sterility

102

View full text Add to dashboard Cite

show abstract

“…It has been shown that embryos that cleave rapid and harmoniously have better probabilities of getting efficiently implanted (Edwards 1998, Kubisch et al 1998, Lonergan et al 1999. Therefore, the retard and asynchrony in preimplantation embryo development reported in this work in adult, both nulliparous and multiparous female hamsters, may be important in explaining the decline in fertility and fecundity that accompany aging (Parkening & Chang 1976, Mizoguchi & Dukelow 1981, Van Kooij et al 1996. It is important to mention that the data on ovulatory rate and reproductive efficiency obtained from the number of CL can be accepted in the case of the golden hamster because in this, and related animal species (Wynne-Edwards et al 1987), no more than one generation of CL is present in the ovaries of cycling female hamsters (Greenwald 1985).…”

Section: Discussionmentioning

confidence: 62%

Effect of maternal age and parity on preimplantation embryo development and transport in the golden hamster (Mesocricetus auratus)

et al. 2005

View full text Add to dashboard Cite

SummaryPreimplantation embryo development was studied in the golden hamster (Mesocricetus auratus). Three groups of regularly cycling female hamsters were used: (I) 30 nulliparous young female (NYF) hamsters; (II) 24 nulliparous adult female (NAF) hamsters and (III) 30 multiparous adult female (MAF) hamsters. Female hamsters were mated with male hamsters of proven fertility. Only 15 min were allowed for mating. The moment of ejaculation was registered. Female hamsters were killed from 60 to 69 h after coitus. Corpora lutea were counted in both ovarian surfaces. Oviducts and uterine horns were flushed separately and embryo number, stage of development and distribution were recorded. Adult female hamsters, nulliparous and multiparous, had significant higher ovulation rates than NYF, but their reproductive efficiency was significantly lower. Preimplantation embryo development and transport were highly synchronous in NYF, but not in adults. Morulae were observed in NYF as early as 62-63 h after coitus. In adult female hamsters, significant numbers of morulae were found until 66-67 h. On the contrary, in NYF four-cell embryos were detected only until 60-61 h, while four-cell embryos were found until 64-65 h in NAF, and until 66-67 h in MAF. Embryo transport from the oviduct to the uterus is practically completed at 62-63 h after coitus in NYF, while it is evidently retarded in adult animals. In NYF all eight-cell embryos reached the uterus by 62 h after coitus. In adult female hamsters, both nulliparous and multiparous, a considerable number of eight-cell embryos fail to migrate into the uterus even at 67 h after coitus.

show abstract

“…Early cleavage embryos with the highest implantation and gestation rates occurred more frequently in younger women. Other studies have already shown the effects of maternal age on hormonal treatment to induce follicular growth, ovulation induction, zygote and embryo quality, implantation and gestation rates (Van Kooij et al, 1996;Lass et al, 1998;Schoolcraft et al, 1999;Schoolcraft et al, 2000;Wittemer et al, 2000). The original study from Gardner et al (1999) did not find any statistical difference in age between the three groups of patients that presented one, two or none top grade blastocysts.…”

Section: Introductionmentioning

confidence: 94%

The impact of age on blastocyst scoring after single and double embryo transfers

Bös-Mikich

Michels

Dutra

et al. 2016

JBRA Assisted Reproduction

View full text Add to dashboard Cite

Objective: The aim of the present study was to assess the putative relationship between patient's age and blastocyst scores, in single (SET) or double (DET) transfer cycles, that resulted in single or twin pregnancy or non-pregnancy. Second, we analyzed the effect of maternal age on clinical gestation and implantation rates after single and double blastocyst transfers. Methods: Retrospective analysis of 164 assisted reproduction cycles with embryo transfers. Results: Data demonstrated that for both, young (<35 years of age) and older (≥35 years of age) women, trophectoderm (TE) score is the most important parameter to assess concerning embryo selection. However, inner cell mass (ICM) also plays an important role on blastocyst selection in the group of older patients. In addition, our data shows that for young women the transfer of a single blastocyst results in similar gestational rates as those for DET. Conclusion: We suggest that blastocyst grading for patients aged 35 years or above shall be performed using a strict grading policy, possibly not of a single parameter, but TE, ICM and expansion grades together, to choose the "best combined-score blastocyst". DETs should be considered, particularly after previous cycles with pregnancy failures.

show abstract

Age-dependent decrease in embryo implantation rate after in vitro fertilization

Cited by 133 publications

References 22 publications

A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles

A poor response in the first in vitro fertilization cycle is not necessarily related to a poor prognosis in subsequent cycles

Effect of maternal age and parity on preimplantation embryo development and transport in the golden hamster (Mesocricetus auratus)

The impact of age on blastocyst scoring after single and double embryo transfers

Contact Info

Product

Resources

About