Age-Dependent Clinicopathological Characteristics of Patients with T1b Papillary Thyroid Carcinoma: Implications for the Possibility of Active Surveillance

Won, Ho-Ryun; Jeon, Eon Ju; Heo, Da Beom; Chang, Jae Won; Shong, Minho; Kim, Je Ryong; Ko, Hyemi; Kang, Yea Eun; Yi, Hyon‐Seung; Joung, Kyong Hye; Kim, Ji Min; Lee, Younju; Kim, Sung Woo; Jeong, Young Ju; Ji, Yong Bae; Tae, Kyung; Koo, Bon Seok

doi:10.1245/s10434-022-13011-z

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Consequently, using more sensitive indicators to assess tumor growth was not deemed beneficial at that time. We find that the diameter of PTC that can be observed is constantly extending: 1 cm for ATA ( 17 ), 1.2 cm for Kuma Hospital ( 2 ), 1.5 cm for Dr. Tuttle RM ( 18 ), and even 2 cm in some literature ( 19 ). However, with the emergency of UGTA, such as RFA, as a third method for PTMC treatment, the landscape has changed.…”

Section: Discussionmentioning

confidence: 73%

Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China

Le,

Jin,

Zhong

et al. 2024

Front. Endocrinol.

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PurposeTo assess tumor growth using tumor doubling rate (TDR) during active surveillance (AS) in China.MethodsBetween January 2016 and June 2020, a total of 219 patients with low-risk papillary thyroid microcarcinoma (PTMC) (aged 23-75 years) were consecutively enrolled in the AS program.ResultsFour sections of TDR, >0.5, 0.1~0.5, -0.1~0.1 and <-0.1, corresponded with four categories of tumor volume kinetics: rapid growth, slow growth, stable, and decreased size. We found that 10.5% of PTMCs exhibited rapid growth, 33.33% exhibited slow growth, 26.48% were stable, and 29.68% decreased in size. Tumor growth was associated with two factors: age and volume of PTMC at diagnosis. 85.72% of elderly patients (≥ 61 years old) had tumors that remained stable or even shrank and rapidly growing tumors were not found in them. When the volume was small (≤14.13 mm3), the proportion of rapid growth was high (41.67%), whereas when the volume was large (> 179.5 mm3), the proportion of non-growth was 68.75%.ConclusionTDR may be a better metric for evaluating tumor growth in observational PTMCs. A certain proportion of PTMCs grow during the period of AS and tumor growth was associated with age and volume of PTMC at initial diagnosis. Therefore, how to block tumor growth during the AS period, especially for young patients and patients with early-stage PTMC (size ≤ 5 mm), will be a new challenge.

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Section: Discussionmentioning

confidence: 73%

Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China

Le,

Jin,

Zhong

et al. 2024

Front. Endocrinol.

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2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules

et al. 2023

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Thyroid nodules are a prevalent condition that can be detected through palpation or ultrasound. However, a small fraction of these nodules can be cancerous, and even benign nodules can cause symptoms if they grow and compress surrounding tissue. As such, it is important to monitor thyroid nodules and determine appropriate treatment options. In recent years, there has been a shift towards enhancing diagnostic accuracy and less aggressive treatment options. As a result, there is a growing need for the development of appropriate Guidelines for Thyroid Nodules

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ASO Author Reflections: Active Surveillance may be Possible in Patients with T1b Papillary Thyroid Carcinoma Over 55 Years of Age Without High-Risk Features on Preoperative Examinations

et al. 2023

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Age-Dependent Clinicopathological Characteristics of Patients with T1b Papillary Thyroid Carcinoma: Implications for the Possibility of Active Surveillance

Cited by 3 publications

References 30 publications

Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China

Tumor growth manifested in two-fifths of low-risk papillary thyroid microcarcinoma patients during active surveillance: data from a tertiary center in China

2023 Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules

ASO Author Reflections: Active Surveillance may be Possible in Patients with T1b Papillary Thyroid Carcinoma Over 55 Years of Age Without High-Risk Features on Preoperative Examinations

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