Age-Dependent Associations Between Sleep-Disordered Breathing and Hypertension

Haas, Donald; Foster, Gregory; Nieto, F. Javier; Redline, Susan; Resnick, Helaine E.; Robbins, John A.; Young, Terry; Pickering, Thomas G.

doi:10.1161/01.cir.0000154540.62381.cf

Cited by 295 publications

(121 citation statements)

References 33 publications

(37 reference statements)

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“…Sleep-Disordered Breathing and Cardiovascular Disease-Endeshaw et al larger data set (SHHS). 11,13 Although use of blood pressure medication may confound the relationship between AHI and measured blood pressure, we did not find any significant association between these variables even after stratifying by status of blood pressure mediation use. One obvious shortcoming with regard to blood pressure measurement in both the current study and previous studies is that wake-time blood pressure was utilized to determine the relationship between AHI and hypertension.…”

Section: Discussioncontrasting

confidence: 70%

“…These relationships were examined in a logistic regression model (Table 4), which showed a significant relationship between SDB and cardiovascular medication use independent of age, sex, and body mass index. Because several different definitions of AHI have been proposed, 17 we also examined how SDB was related to cardiovascular medication use in alternative logistic models paralleling those presented in Table 4 Finally, because recent data have suggested that isolated systolic hypertension may be unrelated to AHI regardless of age, and that relationships between systolic or diastolic hypertension and AHI were present only in individuals younger than 60 years, 13 we more closely examined a potential relationship Includes history of myocardial infarction, coronary artery bypass graft surgery, coronary angioplasty, and cerebrovascular accidents. Includes atrial fibrillation, t-wave abnormalities, atrioventricular block, and left axis deviation.…”

Section: Discussionmentioning

confidence: 99%

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Sleep-Disordered Breathing and Cardiovascular Disease in the Bay Area Sleep Cohort

Endeshaw

Bloom

Bliwise

2008

Sleep

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Sleep-Disordered Breathing and Cardiovascular Disease in the Bay Area Sleep Cohort

Endeshaw

Bloom

Bliwise

2008

Sleep

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“…24,25 The impact of sleep duration on BP may differ depending on age. 26,27 A few studies have investigated the relationship between sleep duration and high BP in children and adolescents, and have reported conflicting results. 28 -31 Presently, there are scant reports on this relationship in Asian populations with large sample sizes.…”

Section: Introductionmentioning

confidence: 99%

Association Between Sleep Duration and Hypertension Among Chinese Children and Adolescents

Guo

Zheng

Yang

et al. 2011

Clinical Cardiology

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Background: Short sleep duration was reported to be associated with an increased risk of hypertension among adults. The present study aimed to investigate this association in children and adolescents. Hypothesis: Short sleep duration is related to higher risk of hypertension among children and adolescents. Methods: We conducted a cross-sectional study of 4902 children and adolescents age 5 to 18 years. Blood pressure (BP) was measured at the research center and classified using the population-based percentiles. Sleep duration and related information were determined through questionnaires. Results: The prevalence of hypertension and prehypertension were 20.3% and 15%, respectively. The median sleep duration was 8.77 ± 1.07 hours (mean ± standard deviation). A short sleep duration (<9 hours) was associated with a higher risk of hypertension when compared with the group sleeping longer (9

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“…The authors speculated that their findings could be related to a survival bias. 29 We also found that patients with hypertension were heavier. Obesity has a putative role in the genesis of hypertension by increasing renal tubular reabsorption, impairing pressure natriuresis, causing volume expansion due to activation of the sympathetic nervous system and renin-angiotensin system.…”

Section: Discussionmentioning

confidence: 61%

“…In addition, age is an independent risk factor for hypertension in the general population. 8 Interestingly enough, recent cross-sectional data from the Sleep Heart Health Study 29 showed that the strong association between sleep-disordered breathing and hypertension was lost for those aged 460 years. The authors speculated that their findings could be related to a survival bias.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic characteristics associated with hypertension in patients with obstructive sleep apnea

et al. 2006

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Obstructive sleep apnea (OSA) causes secondary hypertension. However, the reasons why the prevalence of hypertension among OSA patients varies widely (35-70%) are not clear. We sought to investigate the phenotypic characteristics of patients with and without hypertension among OSA patients who were matched for disease severity. We studied 152 OSA patients (76 normotensive and 76 hypertensive) diagnosed by polysomnography. Detailed phenotypic characteristics, including laboratorial analysis, were determined in all patients. Univariate analysis followed by multiple logistic regression analysis was used to identify variables that were independently associated with hypertension. The apnea-hypopnea index in normotensive and hypertensive patients was similar (48726 and 48726 events/ h, respectively) as well as minimum arterial oxygen saturation (76710 and 75710%, respectively) and total sleep time with oxyhaemoglobin saturation o90% (25725 and 28726%, respectively). Hypertensive patients were older (57711 vs 47712 years; Po0.001), had a higher body mass index (BMI; 3477 vs 3075 kg/m 2 ; Po0.001), had a higher frequency of women (37 vs 8%; Po0.001), had a higher incidence of diabetes (25 vs 6%; P ¼ 0.002) and a higher family history of hypertension (75 vs 42%; P ¼ 0.01) than did the normotensive patients. Multiple logistic regression analysis indicated that age (P ¼ 0.004), familial history of hypertension (P ¼ 0.004), BMI (P ¼ 0.04) and female sex (P ¼ 0.03) were the independent variables associated with hypertension. We concluded that increasing age and BMI, familial history of hypertension as well as female gender are phenotypic characteristics associated with hypertension among OSA patients with similar disease severity.

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Age-Dependent Associations Between Sleep-Disordered Breathing and Hypertension

Abstract: Background-Sleep-disordered breathing (SDB) is associated with hypertension in the middle-aged.

Cited by 295 publications

References 33 publications

Sleep-Disordered Breathing and Cardiovascular Disease in the Bay Area Sleep Cohort

Sleep-Disordered Breathing and Cardiovascular Disease in the Bay Area Sleep Cohort

Association Between Sleep Duration and Hypertension Among Chinese Children and Adolescents

Phenotypic characteristics associated with hypertension in patients with obstructive sleep apnea

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