Age-dependent and region-specific differences in the distribution of trace elements in 7 brain regions of Long-Evans Cinnamon (LEC) rats with hereditary abnormal copper metabolism

Deficiencies of Hippocampal Zn and ZnT3 Accelerate Brain Aging of Rat

“…SAMP10 and SAMR1 of each age were decapitated, and the hippocampus region was separated and decomposed by the method as previously described (27). The Zn and Cu concentrations were determined with an inductively coupled plasma mass spectrometer (ICP-MS, Seiko SPQ-6500, Japan) by the method as previously described (27).…”

Enhanced Mn-SOD Immunoreactivity in the Dopaminergic Neurons of Long-Evans Cinnamon Rats

“…Similarly, it is possible that ROS arising from an accumulation of these metals in the brain may induce the expression of Mn-SOD in LEC rats. Indeed, higher Fe, Mn and Cu levels in most brain regions, including the midbrain have been reported in LEC rats (4).…”

“…In fact LEC rats share many of the clinical and biochemical features of WD patients, and have been proposed as an experimental model for the study of the pathogenesis of WD (3). The disturbance of copper homeostasis and the distribution of other elements, such as manganese, iron and zinc in LEC rats are also evidenced by an excessive accumulation of metal in other organs including the brain (4). Moreover, oxidative stress by such an accumulation in humans with WD might contribute to the neurological abnormalities associated with the disease (1).…”

Accumulation of Copper Induces DNA Strand Breaks in Brain Cells of Long-Evans Cinnamon (LEC) Rats, An Animal Model for Human Wilson Disease

“…1.5 folds) but significantly higher than those in control rats. However, no significant differences were found between copper contents in the cerebral cortex of LEC and control rats at 20 weeks of age [27]. Sugawara et al [37] reported that the copper contents of the brain regions, including the cerebral cortex of LEC rats were slightly (c.a.…”

“…Therefore, LEC rats provide a useful experimental model for Wilson disease [19,31]. The copper contents in the brains of LEC rats have been reported to be significantly lower than those in the brains of control rats at 4 and 7 weeks of age [27,37]. Copper contents in some regions of the brain, such as the cerebellum, in LEC rats were found to be slightly (c.a.…”