Age dependency on some physiological and biochemical parameters of male Wistar rats in controlled environment

Abstract

The aim of the study was to assess the age dependence on some physiological and serum chemistry parameters of male Wistar rats for the estimation of reference values in controlled environment. We are presenting values obtained from a large number of animals such as survival, average life span, body mass, food and water intake, serum chemistry parameters as total protein, albumin, transferrin and ferritin in serum. One part of this work compares the relationship between rat and human age. The maximal life span of our rats was determined to be about 4.4 years. The average life span was 3.75 years. The body weight quickly rose to the 85th week of life and then remained in the range of about 640-660 g up to the 163rd week when it began to decline. Food intake rose from the beginning to the maximum of about 39 g in the 33rd week and then decreased to about 20 g in the 163rd week. The water intake had a similar dynamics (about 43 mL in the 33rd week and 33 mL in the 163rd week). Levels of total protein in serum increased with age, in contrast, albumin levels decreased. Transferrin and ferritin decreased to approximately the 160th week of life and then increased.

1H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats

“…As expected, sarcopenia decreased the gastrocnemius muscle mass according to other studies [17][18][19]. However, tumour evolution did not lead to a further reduction of gastrocnemius muscle mass but was associated with an accentuated decrease in body weight gain.…”

Simulation of Chronic Intoxication in Rats Exposed to Cadmium and Mercury

“…Wirth and Nijal [22] and Calabrese [3] stated that chronic exposure to low doses of mercury can have an unpredictable course (but also consequences) and the body's response to low (subtoxic) doses may be different. Ništiar et al [9] and Shibutani et al [24] stated that the determining indicator of food intake (but also changes in weight and heavy metal intake) is water intake, which only partially corresponds to the results in this study. The opposite situation may also be the fact that food intake is limiting in this respect and water intake is derived from it.…”

“…Thus, the survival was 100% and at the same time it was confirmed that the applied dose is low chronic dose. In a lifelong experiment [9] evaluating the survival of animals exposed to cadmium, more individuals survived (one-year survival was also 100% as confirmed by the experiments) compared to other heavy metals. This may be because cadmium in low doses may function as an essential element [10][11][12].…”

Diminished trkA receptor signaling reveals cholinergic‐attentional vulnerability of aging

“…Data from final sessions were obtained from rats aged 6.11 ± 0.26 and 25.90 ± 0.28 months, respectively. This age of the older rats is considered equivalent to the human post‐reproductive period (60–70 years) and precedes the onset of accelerating mortality of this strain (Nistiar et al ., ).…”