Age dependence of the flow velocity in the basal cerebral arteries—A transcranial Doppler ultrasound study

Grolimund, Peter; Seiler, Rolf W.

doi:10.1016/0301-5629(88)90139-1

Cited by 133 publications

(76 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Arnolds and von Reutern (1986) found a 20% decrease in Doppler shift of MCA from a mean age of 17 to 67 years. Grolimund and Seiler examined 535 patients who had a history of a previous neurological event, but with normal neurological examination, and found that MCA, ACA and PCA velocities decreased by an average of 0.51%, 0.5% and 0.37% per year, respectively (Grolimund and Seiler 1988). Similar with these studies, we also found a wide range of reference velocity values in all vessels of different age groups.…”

Section: Discussionsupporting

confidence: 84%

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Demirkaya

Uluç

Bek

et al. 2008

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Transcranial Doppler sonography (TCD) is a non-invasive diagnostic tool enabling evaluation of blood fl ow characteristics of basal intracerebral vessels via thin calvarian regions. Several factors may affect the normal values of cerebral hemodynamic parameters, and standard reference values for each laboratory are needed for precise interpretation of the results. The aims of this study were to determine normal values of fl ow velocities of basal cerebral arteries of our TCD laboratory, and to study the infl uence of age and gender on normal values. We studied 63 healthy volunteers (30 male and 33 females; age range, 5 -69 years old) with TCD with a 2-MHz transcranial probe. The subjects were divided into 7 age groups: 5-10 years, 11-20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years and > 60 years. Mean velocity (V mean), peak systolic velocity (PSV), and end-diastolic velocities (EDV) were determined in middle, anterior and posterior cerebral arteries. No signifi cant gender difference was found. However, there was a decrease in blood fl ow velocities in all vessels with advancing age, which was signifi cant when subjects older than 40 years and 40 years old were compared. V mean, PSV and EDV values were highest in the age group of 5 -10 years old and lowest in volunteers older than the age of 60 ( p < 0.05). As a conclusion, fl ow velocities in basal cerebral arteries range widely and are signifi cantly age-related. Age matching of TCD data is a requirement for clinically relevant conclusions.transcranial Doppler sonography; basal; cerebral arteries; normal values; healthy subjects. Tohoku

show abstract

Section: Discussionsupporting

confidence: 84%

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Demirkaya

Uluç

Bek

et al. 2008

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Global CBF declines gradually with ageing, by 25-30 % between 20 and 80 years of age (Ainslie et al 2008;Buijs et al 1998;Demirkaya et al 2008;Krejza et al 1999;Liu et al 2011) or~5 % per decade (Grolimund and Seiler 1988). The effect of healthy ageing on cerebrovascular CO2 reactivity is less clear, however.…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Murrell

Cotter

Thomas

et al. 2012

AGE

160

180

View full text Add to dashboard Cite

Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO 2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23±5 years; body mass index ) previously sedentary individuals breathed 5 % CO 2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s −1 (30 and 70 % HRR, respectively) vs. 5 and 4 cm s −1 (older), P<0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87±0.76 vs. 2.54± 1.12 cm s −1 mm Hg −1 , P00.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.

show abstract

“…Several investigators have previously described sex-related differences in CBF in humans (Grolimund, Seiler 1988, Vriens et al 1989, Marinoni et al 1998, Muller, Schimrigk 1994, Krejza et al 1999, Deegan et al 2009), although in most cases, the number of subjects tended to be relatively small and only a few studies reported on CBFV (Deegan et al 2009). Most studies report higher mean blood flow velocities in females over males; however it is questioned whether this difference is limited to specific ages (Vriens et al 1989, Krejza et al 1999).…”

Section: Influence Of Sexmentioning

confidence: 99%

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

et al. 2016

View full text Add to dashboard Cite

Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex.Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15-minute stabilisation, and a 5-minute baseline recording.Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males.Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes. Key wordsCerebral haemodynamics, cerebral autoregulation, ageing, sex differences, cerebral blood

show abstract

Age dependence of the flow velocity in the basal cerebral arteries—A transcranial Doppler ultrasound study

Cited by 133 publications

References 18 publications

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Normal Blood Flow Velocities of Basal Cerebral Arteries Decrease with Advancing Age: A Transcranial Doppler Sonography Study

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

Contact Info

Product

Resources

About