Age dependence of T1 perfusion MRI‐based hemodynamic parameters in human kidneys

Abstract

Purpose: To determine the association between renal cortical perfusion parameters from T1-DCE magnetic resonance imaging (MRI) and age in human kidney. Results: Mean RBF, RVD, and MTT were 127 mL/min/100 mL (SD ϭ 81 mL/min/100 mL), 40 mL/100 mL (SD 23 mL/100 mL), and 22 sec (SD ϭ 9 sec). A significant moderately negative correlation was found between RBF and age (R ϭ Ϫ0.447, P ϭ 0.007), RVD and age (R ϭ Ϫ0.420, P ϭ 0.012). MTT and age did not show a significant correlation (R ϭ 0.017, P ϭ 0.924). Repeating this analysis for each gender revealed a moderate age dependence of RBF (R ϭ Ϫ0.600 with P ϭ 0.009) and RVD (R ϭ Ϫ0.540 with P ϭ 0.021) in the male group only.Conclusion: T1-DCE quantitative perfusion MRI was sufficiently sensitive to demonstrate a significant negative correlation of RBF and RVD with patient age. This was due to a moderate age dependence of these quantities in males that seems to be absent in females.

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

“…Various models [1][2][3][4][5][6][7][8][9][10][11] have been proposed for analysis of renal filtration using DCE-MRI. A critical review [38] showed that none of the published methods was sufficiently e ISD of cortical perfusion is better (14%; see Table 2) f Mean parenchymal perfusion 0 RBF/2*V kid ; RBF01.1 l min [1,46] g Using Eq.…”

“…Dynamic imaging of renal uptake of a contrast agent is an established way of assessing renal physiology using nuclear medicine, dynamic computed tomography and magnetic resonance imaging (MRI), and estimation of quantitative parameters is possible [1][2][3][4][5][6][7][8]. Several reviews are available [9][10][11].…”

Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease

“…Given that many renal pathologies involve vascular and/or perfusion abnormalities, imaging methods that specifically provide robust, serial measurements of kidney hemodynamic status could be of great utility. Toward this end, several MRI methods, using either endogenous or exogenous contrast mechanisms, have demonstrated great promise for the noninvasive assessment of kidney perfusion and oxygen delivery (1)(2)(3)(4)(5)(6). However, the application of these methods has primarily been limited to humans, pigs, rabbits, and rats.…”

4D MRI of polycystic kidneys from rapamycin‐treated Glis3‐deficient mice

“…However, traditional GFR can be inaccurate and does not decrease substantially with the onset and progression of renal cysts (4,8). MRI can be a valuable tool to assess renal function (34)(35)(36)(37)(38)(39). One study showed the decline of renal function with MRI-based GFR in polycystic kidneys (31).…”