Age dependence of otoacoustic emissions: the loss of amplitude is primarily caused by age-related hearing loss and not by aging alone

Hoth, Sebastian; Gudmundsdottir, Katrin Kemp; Plinkert, Peter K.

doi:10.1007/s00405-009-1106-5

Cited by 20 publications

(11 citation statements)

References 33 publications

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“…At least one report failed to see any age effect on DPOAE fine structure (He and Schmiedt 1996). The strong co-variation of hearing threshold and age has posed a vexing problem in determining aging influences on cochlear function in humans (e.g., Oeken et al 2000;Uchida et al 2008;Hoth et al 2010). When strict control for audiometric threshold has been employed in aged adults, the isolated effects of aging on the OAE have been difficult to observe (Stover and Norton 1993).…”

Section: Agingmentioning

confidence: 95%

Maturation and Aging of the Human Cochlea: A View through the DPOAE Looking Glass

Abdala

Dhar

2012

JARO

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Cochlear function changes throughout the human lifespan. Distortion product otoacoustic emissions (DPOAEs) were recorded in 156 ears to examine these changes and speculate as to their mechanistic underpinnings. DPOAEs were analyzed within the context of current OAE generation theory, which recognizes distinct emission mechanisms. Seven age groups including premature newborns through senescent adults were tested with a swept-tone DPOAE protocol to examine magnitude and phase features of both the mixed DPOAE and individual distortion and reflection components. Results indicate (1) 6-8-month-old infants have the most robust DPOAE and component levels for frequencies >1.5 kHz; (2) older adults show a substantial reduction in DPOAE and distortion-component levels combined with a smaller drop in reflection-component levels; (3) all age groups manifest a violation of distortion phase invariance at frequencies below 1.5 kHz consistent with a secular break in cochlear scaling; the apical phase delay is markedly longer in newborns; and (4) phase slope of reflection emissions is most shallow in the older adults. Combined findings suggest that basilar membrane motion in the apical half of the cochlea is immature at birth and that the cochlea of senescent adults shows reduced nonlinearity and relatively shallow reflection-component phase slope, which can be interpreted to suggest degraded tuning.

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Section: Agingmentioning

confidence: 95%

Maturation and Aging of the Human Cochlea: A View through the DPOAE Looking Glass

Abdala

Dhar

2012

JARO

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“…Hudspeth & Corey 1977), and a typically smaller reflection component generated by linear reflections from the DP place (2 f 1 – f 2 ). Others have also reported that older subjects show more significant reductions in DPOAE amplitude than amplitude of the transient-evoked OAE, another reflection-type emission (Hoth et al 2010). Otoacoustic emissions generated by nonlinear distortion in the cochlea may be impacted by aging more than OAEs arising from linear reflection.…”

Section: Introductionmentioning

confidence: 99%

Changes in the Compressive Nonlinearity of the Cochlea During Early Aging: Estimates From Distortion OAE Input/Output Functions

Ortmann

Abdala

2016

Ear &Amp; Hearing

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Objectives The level-dependent growth of distortion product otoacoustic emissions (DPOAEs) provides an indirect metric of cochlear compressive nonlinearity. Recent evidence suggests that aging reduces nonlinear distortion emissions more than those associated with linear reflection. Therefore, in this study we generate input/output (I/O) functions from the isolated distortion component of the DPOAE to probe the effects of early aging on the compressive nonlinearity of the cochlea. Design Thirty adults whose ages ranged from 18–64 years participated in this study, forming a continuum of young to middle-aged subjects. When necessary for analyses, subjects were divided into a young-adult group with a mean age of 21 years, and a middle-aged group with a mean age of 52 years. All young-adult subjects and 11 of the middle-aged subjects had normal hearing; four middle-aged ears had slight audiometric threshold elevation at mid-to-high frequencies. DPOAEs (2f1–f2) were recorded using primary tones swept upward in frequency from 0.5–8 kHz, and varied from 25–80 dB SPL. The nonlinear distortion component of the total DPOAE was separated and used to create I/O functions at one-half octave intervals from 1.3–7.4 kHz. Four features of OAE compression were extracted from a fit to these functions: compression threshold, range of compression, compression slope, and low-level growth. These values were compared between age groups and correlational analyses were conducted between OAE compression threshold and age with audiometric threshold controlled. Results Older ears had reduced DPOAE amplitude compared to young-adult ears. The OAE compression threshold was elevated at test frequencies above 2 kHz in the middle-aged subjects by 19 dB (35 versus 54 dB SPL), thereby reducing the compression range. In addition, middle-aged ears showed steeper amplitude growth beyond the compression threshold. Audiometric threshold was initially found to be a confound in establishing the relationship between compression and age; however, statistical analyses allowed us to control its variance. Correlations performed while controlling for age differences in high-frequency audiometric thresholds, showed significant relationships between the DPOAE I/O compression threshold and age: Older subjects tended to have elevated compression thresholds compared to younger subjects and an extended range of monotonic growth. Conclusions Cochlear manifestations of nonlinearity, such as the DPOAE, weaken during early aging, and DPOAE I/O functions become linearized. Commensurate changes in high-frequency audiometric thresholds are not sufficient to fully explain these changes. The results suggest that age-related changes in compressive nonlinearity could produce a reduced dynamic range of hearing, and contribute to perceptual difficulties in older listeners.

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“…TEOAEs are measured within the 0.5 kHz to 4.0 kHz frequency range, and use a brief pure tone stimulus, while DPOAEs include frequencies up to 8.0 kHz, and use two pure tones that are produced simultaneously [59,60]. Although it is known that the amplitude of OAEs decreases with increasing age and increasing hearing thresholds, OAEs are not optimal to use within the CGA, as the test is highly influenced by environmental noise [61,62].…”

Section: Screening Methods For Age-related Hearing Loss In Older Pmentioning

confidence: 99%

Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature

et al. 2018

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As people grow older, they may experience loss in hearing sensitivity. Age-related hearing loss may negatively affect the patient’s quality of life as it may lead to social isolation. In older patients with cancer, hearing loss can seriously interfere with the patient’s ability to deal properly with all aspects of their disease, and may have a cumulative effect on their already decreased quality of life. Therefore, the proper screening of those conditions is essential in order to optimise the patient’s comfort during and after treatment. This review article aims at providing a concise image of the nature of age-related hearing loss, and provides an overview of the screening methods that could be used in older patients with cancer.

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Age dependence of otoacoustic emissions: the loss of amplitude is primarily caused by age-related hearing loss and not by aging alone

Cited by 20 publications

References 33 publications

Maturation and Aging of the Human Cochlea: A View through the DPOAE Looking Glass

Maturation and Aging of the Human Cochlea: A View through the DPOAE Looking Glass

Changes in the Compressive Nonlinearity of the Cochlea During Early Aging: Estimates From Distortion OAE Input/Output Functions

Screening Methods for Age-Related Hearing Loss in Older Patients with Cancer: A Review of the Literature

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