Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database

Abstract

Sex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events.

Sex-Specific Pharmacotherapy for Migraine: A Narrative Review

“…Ketorolac, an NSAID, which is available in injectable form, has been shown to be effective as a migraine abortive agent (Rao et al, 2016). There is no clinical evidence that ketorolac has a sexrelated difference in its efficacy (Friedman et al, 2015). However, in an animal model of masticatory muscle pain, peripheral application of ketorolac was found to exert a significantly greater effect in female rats (Cairns et al, 2012).…”

Dihydroergotamine infusion for pediatric refractory headache: A retrospective chart review

“…In those that did, results were inconsistent. [33][34][35][36] Guo et al evaluated factors influencing clinical course and treatment response in patients with headaches and noted gender differences in cognitive processing and emotional characteristics, with females showing higher disability. 37 Obesity was common in our sample; and though it is known to correlate with headache frequency and severity in both children and adults, particularly as it pertains to migraine, 8,38 we did not find a statistically significant correlation between BMI and change in pain score across headache types.…”

“…Very few studies have described sex differences in the efficacy of headache therapies. In those that did, results were inconsistent 33–36 . Guo et al evaluated factors influencing clinical course and treatment response in patients with headaches and noted gender differences in cognitive processing and emotional characteristics, with females showing higher disability 37 …”

Migraine Care Challenges and Strategies in US Uninsured and Underinsured Adults: A Narrative Review, Part 2

“…Hydroxyzine possesses anxiolytic qualities and has been studied for use in pain alone and with DHE in migraine . Diphenhydramine is frequently used as a parenteral adjunct for migraine treatment in the ED, though study results have been mixed . Neither drug is listed in the AHS guidelines or the 2000 AAN practice parameter.…”

“…18,19 Diphenhydramine is frequently used as a parenteral adjunct for migraine treatment in the ED, though study results have been mixed. 11,[20][21][22][23][24] Neither drug is listed in the AHS guidelines or the 2000 AAN practice parameter.…”