Age at the time of hip fracture in patients with rheumatoid arthritis is 4 years greater than it was 10 years before, but is still younger than that of the general population

Arai, Kohei; Suzuki, Nobuaki; Murayama, Takayuki; Kondo, Naoki; Otsuka, Hiroshi; Koizumi, Masahiro; Hosaka, Noboru; Fujikawa, Ryuta; Yanabashi, Kazuhito; Sasage, Yosuke; Yoshida, Ken; Kimura, Keishi; Higuchi, Kentaroh; Ajiro, Junya; Endo, Naoto

doi:10.1080/14397595.2018.1561351

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Related studies [56,57] have demonstrated that rheumatoid arthritis increases the risk of hip fracture due to bone loss induced by chronic inflammation, use of glucocorticoids, and physical inactivity. However, rare studies indicated the association between hip fracture and KOA incident.…”

Section: Discussionmentioning

confidence: 99%

Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

et al. 2021

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Objectives We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis (KOA) based on survey data obtained via a random, nationwide sample of Chinese individuals. Methods Data was analyzed from 8193 middle-aged and older adults included in the China Health and Retirement Longitudinal Study (CHARLS). The incident of symptomatic KOA was defined as participants who were free of symptomatic KOA at baseline (CHARLS2011) and diagnosed with symptomatic KOA at the 4-year follow-up (CHARLS2015). The effects of potential predictors on the incident of KOA were estimated using logistic regression models and the final model was internally validated using the bootstrapping technique. Model performance was assessed based on discrimination—area under the receiver operating characteristic curve (AUC)—and calibration. Results A total of 815 incidents of KOA were identified at the 4-year follow-up, resulting in a cumulative incidence of approximately 9.95%. The final multivariable model included age, sex, waist circumference, residential area, difficulty with activities of daily living (ADLs)/instrumental activities of daily living (IADLs), history of hip fracture, depressive symptoms, number of chronic comorbidities, self-rated health status, and level of moderate physical activity (MPA). The risk model showed good discrimination with AUC = 0.719 (95% confidence interval [CI] 0.700–0.737) and optimism-corrected AUC = 0.712 after bootstrap validation. A satisfactory agreement was observed between the observed and predicted probability of incident symptomatic KOA. And a simple clinical score model was developed for quantifying the risk of KOA. Conclusion Our prediction model may aid the early identification of individuals at the greatest risk of developing KOA within 4 years.

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Section: Discussionmentioning

confidence: 99%

Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

et al. 2021

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“…Related studies [57,58] have demonstrated that rheumatoid arthritis increases the risk of hip fracture due to bone loss induced by chronic in ammation, use of glucocorticoids, and physical inactivity. However, rare studies indicated the association between hip fracture and KOA incident.…”

Section: Discussionmentioning

confidence: 99%

Development of a Model for Predicting the 4-year Risk of Symptomatic Knee Osteoarthritis in China: A Longitudinal Cohort Study

Wang

Han

Chen

et al. 2021

Preprint

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Objectives: We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis (KOA) based on survey data obtained via a random, nationwide sample of Chinese individuals.Methods: Data was analyzed from 8,193 middle-aged and older adults included in the China Health and Retirement Longitudinal Study (CHARLS). The incident of symptomatic KOA was defined as participants who were free of symptomatic KOA at baseline (CHARLS2011) and diagnosed with symptomatic KOA at the 4-year follow-up (CHARLS2015). The effects of potential predictors on the incident of KOA were estimated using logistic regression models and the final model was internally validated using the bootstrapping technique. Model performance was assessed based on discrimination—area under the receiver operating characteristic curve (AUC), and calibration. Results: A total of 815 incidents of KOA were identified at the 4-year follow-up, resulting in a cumulative incidence of approximately 9.95%. The final multivariable model included age, sex, waist circumference, residential area, difficulty with activities of daily living (ADLs)/instrumental activities of daily living (IADLs), history of hip fracture, depressive symptoms, number of chronic comorbidities, self-rated health status, and level of moderate physical activity (MPA). The risk model showed good discrimination with AUC = 0.719 (95% confidence interval [CI] 0.700–0.737), optimism-corrected AUC = 0.712 after bootstrap validation. A satisfactory agreement was observed between the observed and predicted probability of incident symptomatic KOA. And a simple clinical score model was developed for quantifying the risk of KOA.Conclusion: Our prediction model may aid the early identification of individuals at the greatest risk of developing KOA within 4 years.

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“…Our ndings indicated that a history of hip fracture was associated with a 53% increase in the risk of KOA. Related studies [47,48] have demonstrated that rheumatoid arthritis increases the risk of hip fracture due to bone loss induced by chronic in ammation, use of glucocorticoids, and physical inactivity. However, studies reporting an association between hip fracture and KOA incidence are rare.…”

Section: Discussionmentioning

confidence: 99%

Development of A Model for Predicting The 4-Year Risk of Systematic Knee Osteoarthritis in China: A Longitudinal Cohort Study

Wang

Han

Chen

et al. 2020

Preprint

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Objectives: We aimed to develop a model for predicting the 4-year risk of knee osteoarthritis (KOA) based on survey data obtained via a random, nationwide sample of Chinese individuals.Methods: We analyzed data from 8,193 middle-aged and older adults included in the China Health and Retirement Longitudinal Study (CHARLS). The incident of systematic KOA was defined as participants were free of systematic KOA at baseline (CHARLS2011) and were diagnosed with systematic KOA at the 4-year follow-up (CHARLS2015). We estimated the effects of potential predictors on the incident of KOA using logistic regression models and validated the final model internally. Model performance was assessed based on discrimination (area under the receiver operating characteristic curve, AUC) and calibration. Results: A total of 815 incident cases of KOA were identified at the four-year follow-up, resulting in a cumulative incidence of approximately 9.95%. The final multivariate model included age, sex, waist circumference, residential area, difficulty with activities of daily living (ADLs)/instrumental activities of daily living (IADLs), history of hip fracture, depressive symptoms, number of chronic comorbidities, self-rated health status, and level of moderate physical activity (MPA). The bias-corrected AUC for this model was 0.704. The calibration curve revealed satisfactory agreement between the observed and predicted incidence of systematic KOA. A simple clinical score model was developed for easily quantifying the risk of KOA based on these factors.Conclusion: Our prediction model may aid in the early identification of individuals at the greatest risk of developing KOA within 4 years.

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Age at the time of hip fracture in patients with rheumatoid arthritis is 4 years greater than it was 10 years before, but is still younger than that of the general population

Cited by 4 publications

References 28 publications

Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

Development of a model for predicting the 4-year risk of symptomatic knee osteoarthritis in China: a longitudinal cohort study

Development of a Model for Predicting the 4-year Risk of Symptomatic Knee Osteoarthritis in China: A Longitudinal Cohort Study

Development of A Model for Predicting The 4-Year Risk of Systematic Knee Osteoarthritis in China: A Longitudinal Cohort Study

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