Age at natural menopause in three Central and Eastern European urban populations: The HAPIEE study

Stepaniak, Urszula; Szafraniec, Krystyna; Kubínová, Růžena; Malyutina, Sofia; Peasey, Anne; Pikhart, Hynek; Pająk, Andrzej; Bobák, Martin

doi:10.1016/j.maturitas.2013.02.008

Cited by 53 publications

(44 citation statements)

References 32 publications

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“…12 Moreover, menopause is very unlikely to occur before the age of 40 years; the risk of natural menopause before age 40 is approximately 1%. 13 Therefore, we defined fertile age between 15 and 40 years. Time to diagnosis, AQP4-ab status, dis ease classification, and the annualized relapse rate (ARR) were analysed according to age at disease onset.…”

Section: Methodsmentioning

confidence: 99%

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

et al. 2016

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Background: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases. Objective: To evaluate the impact of female sex and fertile age on aquaporin-4-antibody (AQP4-ab) status, attack localization, and response to attack treatment in patients with neuromyelitis optica (NMO) and its spectrum disorders (neuromyelitis optica spectrum disorder (NMOSD)). Methods: Female-to-male ratios, diagnosis at last visit (NMO vs NMOSD), attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset. Results: A total of 186 NMO/SD patients (82% female) were included. In AQP4-ab-positive patients, female predominance was most pronounced during fertile age (female-to-male ratio 23:1). Female patients were more likely to be positive for AQP4-abs (92% vs 55%; p < 0.001). Interval between onset and diagnosis of NMO/SD was longer in women than in men (mean 54 vs 27 months; p = 0.023). In women, attacks occurring ⩽40 years of age were more likely to show complete remission (p = 0.003) and better response to high-dose intravenous steroids (p = 0.005) compared to woman at >40 years. Conclusion: Our data suggest an influence of sex and age on susceptibility to AQP4-ab-positive NMO/ SD. Genetic and hormonal factors might contribute to pathophysiology of NMO/SD.

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Section: Methodsmentioning

confidence: 99%

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

et al. 2016

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“…And indeed, youth is one of the most important factors of women's attractiveness (Buunk et al ., ). Then, for a given age, the temporal reproductive window will vary according to the age at menopause, which is highly variable both across and within populations (Avis et al ., ; Thomas et al ., ; Velde et al ., ; Dratva et al ., ; Morris et al ., ; Stepaniak et al ., ). If the future age at menopause is somehow detectable in young adults, it could contribute substantially to mate choice and thus influence female attractiveness.…”

Section: Introductionmentioning

confidence: 97%

Women's attractiveness is linked to expected age at menopause

Bovet

Barkat‐Defradas

Durand

et al. 2017

J of Evolutionary Biology

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A great number of studies have shown that features linked to immediate fertility explain a large part of the variance in female attractiveness. This is consistent with an evolutionary perspective, as men are expected to prefer females at the age at which fertility peaks (at least for short-term relationships) in order to increase their reproductive success. However, for long-term relationships, a high residual reproductive value (the expected future reproductive output, linked to age at menopause) becomes relevant as well. In that case, young age and late menopause are expected to be preferred by men. However, the extent to which facial features provide cues to the likely age at menopause has never been investigated so far. Here, we show that expected age at menopause is linked to facial attractiveness of young women. As age at menopause is heritable, we used the mother's age at menopause as a proxy for her daughter's expected age of menopause. We found that men judged faces of women with a later expected age at menopause as more attractive than those of women with an earlier expected age at menopause. This result holds when age, cues of immediate fertility and facial ageing were controlled for. Additionally, we found that the expected age at menopause was not correlated with any of the other variables considered (including immediate fertility cues and facial ageing). Our results show the existence of a new correlate of women's facial attractiveness, expected age at menopause, which is independent of immediate fertility cues and facial ageing.

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“…Further, some studies in women of European descent observed later ANM with higher educational level (Kaczmarek, ; Martin et al, ; Stepaniak et al, ). A previous meta‐analysis (Sun et al, ) observed that current smokers presented an approximate twofold risk of an earlier ANM compared to nonsmokers, and women with an active lifestyle had a later ANM (Dratva et al, ; Gudmundsdottir, Flanders, & Augestad, ; Stepaniak et al, ). Emaus et al () suggested that physical activity was associated with a later ANM only in former‐ or current‐heavy smokers, and had no effect on ANM in the absence of smoking.…”

Section: Introductionmentioning

confidence: 99%

The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC‐Spain sub‐cohort

Luján-Barroso

Gibert

Obón-Santacana

et al. 2018

American J Hum Biol

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Objective: To determinate the role of lifestyle factors, recent diet, menstrual factors, and reproductive history in age at natural menopause in adult Spanish women. Methods: In total, 12 562 pre-menopausal women were available for analysis from the EPIC-Spain sub-cohort. Women were recruited between 1992 and 1996 in five regions of Spain (Asturias, Granada, Murcia, Navarra, and San Sebastian) and, for these analyses, were followed for 3 years. Questionnaires on diet, lifestyle, anthropometric measurements, and reproductive and exogenous hormones history were collected at baseline. Menopause status was updated at a median of 3 years of follow-up. Results: After a median of 3 years of follow-up 1166 women became postmenopausal. An earlier age at menopause was observed in current smokers (HR: 1.29; 95%CI 1.08-1.55) and in non-users of oral contraceptives (HR: 1.32; 95%CI 1.01-1.57). A later age at menopause was observed in women with irregular menses (HR: 0.71; 95%CI 0.56-0.91) and in women with a higher number of pregnancies (HR: 0.74; 95%CI 0.56-0.94). Conclusions: Our results confirm that women who smoked had an earlier age at natural menopause, while use of oral contraceptives, higher number of pregnancies, and irregularity of menses were associated with a prolonged reproductive lifespan. No associations were observed for dietary habits assessed after the age of 40 years.

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Age at natural menopause in three Central and Eastern European urban populations: The HAPIEE study

Cited by 53 publications

References 32 publications

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

Women's attractiveness is linked to expected age at menopause

The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC‐Spain sub‐cohort

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