Age at Menopause in Central Andean Peruvian Women

Gonzáles, Gustavo F.; Villena, Arturo

doi:10.1097/00042192-199704010-00008

Cited by 47 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This could be related to the delayed presentation of adrenarche and delayed onset of puberty observed in girls living at high altitude compared with those living at sea level (Góñez et al 1993, Gonzales et al 1996. Early age at adrenopause could also be related to the early onset of menopause observed at high altitude (Gonzales & Villena 1997). These data suggest that maturation is delayed and aging accelerated in women living at high altitude.…”

Section: Discussionmentioning

confidence: 84%

“…Treatment with DHEA for 3 (Morales et al 1994) or 6 months (Morales et al 1998) resulted in improvement of physical and psychological well-being in aged men and women. Gonzales & Villena (1997) and León-Velarde et al (1997) have demonstrated that median age at menopause occurs earlier at high altitudes in the Central Andes than at sea level in Peru. It is known that women of a younger age at menopause also have a lower life expectancy (WHO 1996).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude

Gonzales¹,

Góñez²,

Villena³

2002

Journal of Endocrinology

View full text Add to dashboard Cite

The present study aimed to determine adrenopause or reduction of serum adrenal androgens with age at high altitude and at sea level. It was a cross-sectional study performed in 210 women resident at high altitude (4340 m) and 123 women living in Lima (150 m), aged 20-70 years. Fasting early morning blood samples were obtained. Serum dehydroepiandrosterone (DHEA), DHEA sulphate (DHEAS), androstenedione, testosterone and estradiol were measured by radioimmunoassay. Serum testosterone concentrations were greater in women living at high altitude than in those resident at sea level. Serum concentrations of DHEA, DHEAS and androstenedione were lower in women living at high altitude than in those living at sea level. The DHEAS/DHEA ratio was significantly greater, and the androstenedione/testosterone ratio was lower in samples from women living at high altitude. Among women older than 50 years of age, a greater decline in serum concentrations of DHEA was observed in those living at high altitude than in those living at sea level. Among women 60-70 years of age, serum concentrations of DHEA at high altitude were 46·9% of those in women of the same age living at sea level. Decay of DHEAS at sea level and at high altitude occurred from the age of 40 years. The decline was faster at high altitude than at sea level, and in women aged 60-70 years serum values of DHEAS at high altitude were 56% of those at sea level. In the same age group, serum concentrations of androstenedione among those native to high altitudes were 27·34% of the value at sea level. At sea level, serum testosterone concentrations did not change with age from 20 to 70 years. In women aged 20-39 years and 50-59 years, serum testosterone concentrations were greater at high altitude than at sea level (P<0·05). In those aged 60-70 years, the concentrations were similar in those living at sea level and at high altitude. At sea level and at high altitude, the serum testosterone/estradiol ratio increased with age (P<0·0034 and P<0·0001 respectively). This ratio increased at an earlier age among those living at high altitude (40-49 years) than among those living at sea level (50-59 years). Multivariate analysis showed that altitude (P<0·0001) and greater chronological age (P<0·001) were associated with lower serum DHEAS concentrations. DHEAS was related to chronological age (P<0·0001). Low serum androstenedione concentrations were related to living at high altitude at birth and greater chronological age (P<0·0001). In conclusion, adrenopause is attained earlier and is of greater magnitude at high altitude than at sea level.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude

Gonzales¹,

Góñez²,

Villena³

2002

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Low parity or nulliparity, on the other hand, has been associated with attainment of menopause at an early age 53,54 . It is interesting to note that Peruvian and Mayan women, despite their high parity, have been reported to experience menopause early, ranging from 45 to 47 years 55,56 .…”

Section: Discussionmentioning

confidence: 99%

Age at menopause and factors associated with attainment of menopause in an urban community in Ibadan, Nigeria

OlaOlorun

2009

Climacteric

View full text Add to dashboard Cite

show abstract

“…3 Diet also plays an important role in the menopause. Not only does it affect the timing but also the after conditions associated with menopause.…”

Section: Relation Of Average Age Of Menopause With Bmimentioning

confidence: 99%

Correlation of body mass index and age of menopause in women attending medicine and gynaecology department of a tertiary care centre

Maru

Verma

et al. 2016

Int J Res Med Sci

View full text Add to dashboard Cite

Age at Menopause in Central Andean Peruvian Women

Cited by 47 publications

References 0 publications

Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude

Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude

Age at menopause and factors associated with attainment of menopause in an urban community in Ibadan, Nigeria

Correlation of body mass index and age of menopause in women attending medicine and gynaecology department of a tertiary care centre

Contact Info

Product

Resources

About