Age at menopause and lung function: A Mendelian randomization study

Plaat, Diana van der; Pereira, Miguel; Pesce, Giancarlo; Potts, James; Amaral, André F.S.; Dharmage, Shyamali; Garcia‐Aymerich, Judith; Gómez-Real, Francisco; Jarvis, Deborah; Minelli, Cosetta; Leynaert, Bénédicte

doi:10.1183/13993003.congress-2018.pa1275

Cited by 1 publication

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“…However, despite supporting findings from experimental studies, there is little evidence from clinical or epidemiological studies. In women, hormonal balance might be especially important, as changes of the hormonal status such as those occurring with menopause, have been associated with lung function decline [2,3]. In peripheral tissues, androgens and estrogens are produced intracellularly from dehydroepiandrosterone (DHEA) [4].…”

Section: Introductionmentioning

confidence: 99%

Low serum DHEA-S is associated with impaired lung function in women

et al. 2020

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Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999À2002 and in 2010À2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999À2002 with incidence of restrictive pattern and airflow limitation in 2010À2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.

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Section: Introductionmentioning

confidence: 99%