Age at menarche predicts age at onset of major affective and anxiety disorders

Tondo, Luigi; Pinna, Marco; Serra, Giulia; Lepre, Chiara; Baldessarini, Ross J.

doi:10.1016/j.eurpsy.2016.08.001

Cited by 18 publications

(20 citation statements)

References 69 publications

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“…For instance, early or late maternal AFB is associated with offspring's risk to schizophrenia (SCZ) 4 , bipolar disorder (BIP) 8 , attentiondeficit/hyperactivity disorder (ADHD) 7 , autism spectrum disorder (ASD) 9 and depression 10 in offspring. Age at menopause and menarche also tend to be correlated with the risk of adverse mental health outcomes in offspring [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…It would be interesting, for example, to estimate the extent of shared genetic architecture between reproductive traits and a wider range of psychiatric disorders. This would elucidate the latent relationship underlying the epidemiological observations of a phenotypic association between psychiatric disorders and reproductive traits 13,14 , which in turn contributes to improving reproductive health in women.…”

Section: Introductionmentioning

confidence: 99%

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The genetic relationship between female reproductive traits and six psychiatric disorders

Amare

Zhou

et al. 2018

Preprint

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Female reproductive behaviors have an important implication in evolutionary fitness and health of offspring. Previous studies have shown that age at first birth of women (AFB) is genetically associated with schizophrenia (SCZ). However, for most other psychiatric disorders and reproductive traits, the latent shared genetic architecture is largely unknown. Here we used the second wave of UK Biobank data (N=220,685) to evaluate the association between five female reproductive traits and polygenetic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N=429,178). We found that the PRS of attentiondeficit/hyperactivity disorder (ADHD) were strongly associated with AFB (genetic correlation of -0.68 ± 0.03 with p-value = 1.86E-89), age at first sexual intercourse (AFS) (-0.56 ± 0.03 with p-value = 3.42E-60), number of live births (NLB) (0.36 ± 0.04 with p-value = 4.01E-17) and age at menopause (-0.27 ± 0.04 with p-value = 5.71E-13). There were also robustly significant associations between the PRS of eating disorder (ED) and AFB (genetic correlation of 0.35 ± 0.06), ED and AFS (0.19 ± 0.06), Major depressive disorder (MDD) and AFB (-0.27 ± 0.07), MDD and AFS (-0.27 ± 0.03) and SCZ and AFS (-0.10 ± 0.03). Our findings reveal the shared genetic architecture between the five reproductive traits in women and six psychiatric disorders, which have a potential implication that helps to improve reproductive health in women, hence better child outcomes. Our findings may also explain, at least in part, an evolutionary hypothesis that causal mutations underlying psychiatric disorders have positive effects on reproductive success.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The genetic relationship between female reproductive traits and six psychiatric disorders

Amare

Zhou

et al. 2018

Preprint

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“…With neoteny a classic feature in the domestication syndrome, it is notable that small head circumference (less than 32 cm at birth) has been found to correlate with later diagnosis of BD by Pugliese et al (2019); inadequate maternal weight gain was inversely associated with BD (while positively associated with SZ). Considering another aspect of neoteny, evidence is mixed as to whether age at menarche is delayed (Bisaga et al, 2002) or not significantly different (Dunjic-Kostic et al, 2016) in women with BD compared to healthy controls (Williams et al, 2007; Tondo et al, 2017). (Further complicating the picture, girls with early menarche experience higher rates of BD and other psychiatric conditions (Platt et al, 2017). )…”

Section: Domestication Features In Bdmentioning

confidence: 99%

Abnormal features of human self-domestication in bipolar disorder

Benítez‐Burraco

Hansen

2020

Preprint

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Bipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, and it is not still clear how genes contribute to the onset and course of the disease. In this paper we adopted an evolutionary-genomic approach to this condition, focusing on changes occurring during human evolution as a source of our distinctive cognitive and behavioral phenotype. We show clinical evidence that the BD phenotype can be construed as an abnormal presentation of the human self-domestication phenotype. We further demonstrate that candidate genes for BD significantly overlap with candidates for mammal domestication, and that this common set of genes is enriched in functions that are important for the BD phenotype, especially neurotransmitter homeostasis. Finally, we show that candidates for domestication are differentially expressed in brain regions involved in BD pathology, particularly, the hippocampus and the prefrontal cortex. Overall, this link between domestication and BD should facilitate a better understanding of the BD etiopathology.

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“…Women of ages 12-16 years are taken as peri menarche. 10 and 45-55 years are considered as perimenopause. 11 One year after delivery and six months after abortion are considered as post-partum and post-abortion respectively.…”

Section: Aims and Objectivesmentioning

confidence: 99%

First episode depression in women- a study of clinical characteristics through the female reproductive stages in a rural tertiary care center in Kerala

Geo

Krishnan

Benjamin

et al. 2019

KJP

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Background: The lifetime prevalence of major depressive disorders is 10-25% for women and 5-12% for men. Women are more prone to develop depressive episode from the period of menarche to the perimenopausal period. Relatively little research has been done on this. Materials and methods: Female patients between the ages of 12 years to 55 years presenting in the outpatient department with first episode depressive symptoms are selected (ICD 10), and the number of patients presenting in different stages of the reproductive cycle-peri menarche, pregnancy, post-partum, post-abortion and perimenopausal are noted. Age at onset, severity of the illness, positive family history, presence of somatic and hypochondriac symptoms, and suicidal intent (Beck suicidal intent scale, Hamilton rating scale for depression) were noted. Results and Discussion: Out of the total 120 patients, 53 were in the perimenopause state, 23 in the peri menarche, 5 in pregnancy, 14 in the post-partum, and 7 as post-abortion. The mean age of onset of depressive disorders was 36.7 years (SD-13.67).The severity of the depressive episode is significantly higher towards the younger age group (<30years) (2 − 24.315, p-value.002) and the number of patients presenting with somatic symptoms are much higher towards the older age group (41-55years) (2-13.760 p value-.008). There is no significant difference in the presence of positive family history, hypochondriasis and suicidal intent among various age groups. Perimenopausal and peri menarche periods show a higher prevalence of depressive disorders during the female reproductive cycle. Conclusion: There is a high prevalence of depression during female reproductive phases. More studies based on female reproductive hormonal changes and mood disorders are needed to prove the association.

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Age at menarche predicts age at onset of major affective and anxiety disorders

Abstract: Age at menarche in Sardinia, as elsewhere, has declined over the past decades. It was strongly associated with age at onset of bipolar and anxiety, as well as major depressive disorders across the age range, suggesting sustained effects of biological maturational factors.

Cited by 18 publications

References 69 publications

The genetic relationship between female reproductive traits and six psychiatric disorders

The genetic relationship between female reproductive traits and six psychiatric disorders

Abnormal features of human self-domestication in bipolar disorder

First episode depression in women- a study of clinical characteristics through the female reproductive stages in a rural tertiary care center in Kerala

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