Age at last birth and risk of developing epithelial ovarian cancer: a meta-analysis

Wu, Yanjun; Xin, Xueling; Wang, Weijing; Zhang, Dongfeng

doi:10.1042/bsr20182035

Cited by 11 publications

(6 citation statements)

References 57 publications

(75 reference statements)

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“…Maternal ALB has been reported to influence future chronic diseases 9 . For instance, a last birth at an advanced age has been reported to be positively associated with longevity, whereas other reports suggest a negative association of ALB with gynecologic cancers 36,37 . However, unlike other critical reproductive-history events like ages at menarche, first birth, and menopause, the role of ALB and CVD events later in life has not been widely studied.…”

Section: Discussionmentioning

confidence: 99%

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

et al. 2023

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Objective: Maternal age at last birth (ALB) of child is increasing in the United States, and it has been reported to influence future chronic diseases. However, the relationship of ALB and cardiovascular disease (CVD) events later in life has not been widely studied. We evaluated the association of ALB with CVD mortality.Methods: Data were from 7,971 parous postmenopausal women older than 45 years who participated in the US National Health and Nutritional Examination Survey from 1999 to 2018 and had mortality follow-up data through to December 31, 2019. ALB was self-reported, whereas CVD mortality was assessed using International Classification of Diseases codes. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The mean age of participants was 63 ± 9.8 years, with 9.5% being non-Hispanic Black, 9.7% being Hispanic women, and 21% reporting ALB ≥35 years. During a median follow-up of 8.1 years, 443 participants died from CVD. In age-adjusted models, CVD mortality was elevated for women with ALB of <25 years (HR, 1.68; 95% CI, 1.23-2.29) and ALB of ≥35 years (HR, 1.37; 95% CI, 1.00-1.88). However, after additional adjustment for race and ethnicity, foreign born, education, marital status, poverty income ratio, parity, smoking status, age at menarche, oral contraceptive pills use and family history of myocardial infarction, these estimates were attenuated resulting in no association between ALB and CVD mortality.Conclusions: In this study of nationally representative sample of postmenopausal women, there was no conclusive association between maternal ALB and CVD mortality later in life.

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Section: Discussionmentioning

confidence: 99%

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

et al. 2023

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“…Four children had a reduced risk of 0.58. In a meta-analysis of age at last birth and epithelial ovarian cancer (39) information from 2,451,071 women with 19,959 cases age at last birth were negatively associated, 0.77 with no change when adjusted for parity (36).…”

Section: Discussionmentioning

confidence: 99%

“…The dashed lines are the 90% quantile for the first and last child. With 10 children is the 80% interval for the first birth (20,27) years and for the last birth (39,46)…”

Section: Methodsmentioning

confidence: 99%

The curvilinear relationships between grand parity and incidence of hormone-dependent cancers; follow-up of postmenopausal women in the Norwegian 1960 Census

Lund,

Busund,

Holden

2023

Preprint

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Breast, ovarian and endometrial cancers are named hormone dependent cancers (HDC) because of the effects of endogenous hormones, including parity, on the incidence rates. Here, we will test the hypothesis that each additional child has the same relative preventive effect on the risk of each of the three cancer sites and with similar shapes of the incidence curves over the extended exposure range, 1 - 18 children in postmenopausal women.The study is based on parity information from the Norwegian 1960 Census for women aged 45-89 years. A total of 385 816 married women answered the question of number of children in present marriage to a civil servant. Follow-up continued until the first of any of the HDC diagnosis, death, or end of follow-up 2005 through linkages based on the unique Norwegian birth number. Included were 16 905 breast cancers, 3 827 ovarian cancers and 3 834 endometrial cancers. Based on person-years (PY), the percentage change in incidence rates of the three cancer sites for each additional child was calculated using a logit regression model including models with higher order terms. A new statistical method for analyses of collinearity between parity and age at first birth has been developed. Age at marriage was used as a proxy for age at first birth.Parity had strong linear effects on the incidence rates for all three cancer sites (p<2e-16). The percentage decrease for each of the cancer diagnosis for an additional child were for breast cancer 10.5% (95% CI; 9.6-11.4), ovarian cancer 13.2% (11.2-15.3) and endometrial cancer 10.9% (8.9-12.8) with similar curvilinear relationship. Models with higher order terms gave slightly better fit to the data with a stronger protective effect for increasing parity on ovarian cancers, while for breast cancer age became more important. Combining the incidence of all three cancers gave a percentage decrease for each additional child of 11.0% (10.1-11.8). The risk for HDC cancer was reduced with earlier age at marriage (first birth) for women with 1-2 children for breast cancer and ovarian cancer and 1 child for endometrial cancer, but the effect was smaller than one additional child. Age of the women at marriage was not significant for the sum of the three cancers.The study demonstrated the strong, regular protective effect of each additional child or full-term pregnancy on the incidence rates of the hormone-dependent cancers throughout the exposure range and with similar curvilinear relations. Reduced fertility is a common, strong etiological factor for the three hormone-dependent cancers in postmenopausal women. These findings support a hypothesis that similar immunological changes during each pregnancy could be the biological explanation.

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“…Age at first birth, parity, and nonmarital births have been studied a great deal, but other components of childbearing might also be correlated with midlife health. Age at last birth is typically studied in relation to very specific health outcomes (e.g., cancer risk; Setiawan et al, 2012; Wu et al, 2019), and thus the overall health impact of this childbearing characteristic is unknown. A later age at last birth also designates women who are still experiencing pregnancy and childbirth into midlife (e.g., 40s) (Carlson & Guzzo, 2021), contributing to potentially different midlife health experiences compared to women whose last births were earlier in adulthood.…”

Section: Childbearing Characteristics Associated With Midlife Healthmentioning

confidence: 99%

Childbearing Biographies and Midlife Women’s Health

2022

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Objectives We introduce a “childbearing biography” approach to show how multiple childbearing characteristics cluster in ways significant for midlife health. Methods We analyze the National Longitudinal Survey of Youth 1979 (NLSY79; N = 3992) using mixed-mode Latent Class Analysis with eight childbearing variables (e.g., age at first birth, parity, birth spacing, and mistimed births) to identify how childbearing biographies are associated with midlife health, adjusting for key covariates—including socioeconomic status (SES) and relationship history. Results We identify six childbearing biographies: (1) early compressed, (2) staggered, (3) extended high parity, (4) later, (5) married planned, and (6) childfree. Childbearing biographies are strongly associated with physical health but not mental health, with differences primarily explained by SES. Discussion Different childbearing biographies are related to physical health inequalities above what is demonstrated by the typical use of one or two childbearing measures, providing a new perspective into the growing health gap among aging midlife women.

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Age at last birth and risk of developing epithelial ovarian cancer: a meta-analysis

Cited by 11 publications

References 57 publications

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

Maternal age at birth of last child and cardiovascular disease mortality later in life among a national cohort of postmenopausal women from the United States

The curvilinear relationships between grand parity and incidence of hormone-dependent cancers; follow-up of postmenopausal women in the Norwegian 1960 Census

Childbearing Biographies and Midlife Women’s Health

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