Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis

Feldtkeller, Ernst; Khan, Muhammad Asim; Heijde, Desirée van der; Linden, Sjef van der; Braun, Jürgen

doi:10.1007/s00296-002-0237-4

Cited by 725 publications

(468 citation statements)

References 9 publications

Supporting

Mentioning

404

Contrasting

Unclassified

Order By: Relevance

“…The average age of disease onset in men is approximately 25 years [9]. Normal values for anthropometric measurements may vary among human populations, especially with differences in race [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Normal range of spinal mobility for healthy young adult Turkish men

2011

View full text Add to dashboard Cite

Anthropometric characteristics may vary among human populations, especially with differences in race. The aim of the present study is to find normal values of some measures (chest expansion, Schober's test and modified Schober's test) frequently used in the assessment of patients with ankylosing spondylitis, in young adult Turkish men. Initial recruitment identified 2,925 healthy male participants aged 20-30 years, and the final study sample included 1,982 of them. Participants joined the research from all cities except one in Turkey. The measurements of chest expansion, Schober's test, and modified Schober's test were performed by the same researcher using a plastic measuring tape. The mean (±standard error) values of the chest expansion, Schober's test, and modified Schober's test were 6.11 (±0.02), 5.62 (±0.02), and 7.78 (±0.02) cm, respectively. The estimated normal lower bounds for chest expansion, Schober's test, and modified Schober's test may be between 3.71-3.86 cm, 3.86-3.97 cm, and 5.46-5.60 cm, respectively, for young adult Turkish men. No correlation was found between height and spinal mobility. The normal values for spinal mobility in this sample of healthy young adult Turkish men differed from those reported for other young adult male populations (chest expansion ≥5 cm, Schober's test >5 cm, modified Schober's test >7 cm). It is thus useful to consider nationality in interpreting results of spinal mobility tests.

show abstract

Section: Introductionmentioning

confidence: 99%

Normal range of spinal mobility for healthy young adult Turkish men

2011

View full text Add to dashboard Cite

show abstract

“…Es gibt mehrere Ursachen für die ausgeprägte Diagnoseverzögerung (oft 5-10 Jahre; [11,18]) bei der AS und der Gesamtgruppe der Spondyloarthritiden. Eine davon ist das geforderte röntgenologi-sche Kriterium (definitive Sakroiliitis mindestens des 2.…”

Section: Relevanz Der Frühen Diagnoseunclassified

Frühe Spondyloarthritiden

Poddubnyy

Rudwaleit²,

Sieper³

2012

Z. Rheumatol.

View full text Add to dashboard Cite

The diagnosis of axial spondyloarthritis (SpA) or ankylosing spondylitis (AS) is often delayed by 5-10 years after the first symptoms have appeared. In order to improve the early diagnosis of SpA an evidenced-based algorithm including clinical, laboratory and imaging parameters was developed. Moreover, the recently published ASAS criteria for axial and peripheral SpA should give rheumatologists more confidence in making the diagnosis of SpA and provide further support for the SpA concept. Furthermore, an easy strategy for the recognition of patients with a high probability of AS/SpA on the primary care level has been developed and recently validated.

show abstract

“…Dies kann als ein wichtiges weiteres Argument dafür angesehen werden, dass die Diagnose bei diesen Patienten früher gestellt werden muss. Bisher wird immer noch über eine Verzöge-rung vom Auftreten der Erstsymptome bis zur Diagnosestellung von 5-10 Jahren berichtet [8].…”

Section: Infobox 1 Zusatzinformationenunclassified

Diagnose und Therapie der axialen Spondyloarthritis einschließlich des Morbus Bechterew

Poddubnyy

Sieper

2012

Orthopäde

View full text Add to dashboard Cite

The term axial spondyloarthritis covers patients with established structural changes visible on x-ray in sacroiliac joints and/or in the spine (classical ankylosing spondylitis) but also patients with non-radiographic axial spondyloarthritis in whom early inflammatory signs of the disease can only be visualized with magnetic resonance imaging (MRI). The MRI technique plays an important role in the diagnosis of this disease and an early diagnosis is normally based on a combination of clinical, laboratory and imaging parameters. Only non-steroidal anti-inflammatory drugs and TNF-α blockers are effective in the treatment of axial spondyloarthritis. Patients with short disease duration and elevated acute phase reactant levels demonstrate best therapy response and, therefore, should be closely followed-up and consistently treated.

show abstract

Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis

Cited by 725 publications

References 9 publications

Normal range of spinal mobility for healthy young adult Turkish men

Normal range of spinal mobility for healthy young adult Turkish men

Frühe Spondyloarthritiden

Diagnose und Therapie der axialen Spondyloarthritis einschließlich des Morbus Bechterew

Contact Info

Product

Resources

About