Age at death as a useful indicator of healthy aging at population level: a 50-year follow-up of the Italian Rural Areas of the Seven Countries Study

Menotti, Alessandro; Puddu, Paolo Emilio; Maiani, Giuseppe; Catasta, Giovina

doi:10.1007/s40520-017-0874-9

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…Major cardiovascular events were coded following the 9th Revision of the WHO-International Classification of Diseases 17 for the Gubbio study and 8th Revision of the WHO-International Classification of Diseases for the IRA study 18 . Details on the diagnostic procedures and criteria are reported elsewhere for Gubbio 19,20 or IRA studies 21,22 .…”

Section: Methodsmentioning

confidence: 99%

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts

Humbert

Fédrizzi

Alexandre

et al. 2019

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To assess the impact of sex on office white-coat effect tail (OWCET), the waning of systolic blood pressure (SBP) after its waxing during office visit, on the incidence of long-term major fatal and non-fatal events in two Italian residential cohorts [from the Gubbio Study and the Italian Rural Areas of the Seven Countries Study (IRA)]. There were 3565 persons (92 with missing data, 44% men, 54 ± 11 years) included in the Gubbio and 1712 men (49 ± 5 years) in the IRA studies. OWCET was defined as a decrease of ≥10 mmHg in SBP between successive measurements with slight measurement differences between the two cohorts. Cardiovascular (CVD), coronary heart disease (CHD) and stroke (STR) incidences were considered. Over an approximately 20-year follow-up, women with OWCET had an increased risk of CVD [HR: 1.591 (95%CI: 1.204–2.103)], CHD [HR: 1.614 (95%CI: 1.037–2.512)] and STR [HR: 1.696 (95%CI: 1.123–2.563)] events independently of age, serum and HDL cholesterol, cigarettes, BMI and SBP in the Gubbio study. However, there was no increased risk of CVD, CHD or STR in men with OWCET neither in the Gubbio 20-year follow-up nor in the IRA 50-year follow-up. These results were not modified significantly by the correction of the regression dilutions bias between the first and the subsequent SBP measurements. Thus, in primary care, OWCET should be actively evaluated in women as it can improve stratification of long-term CVD, CHD and STR risks.

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Section: Methodsmentioning

confidence: 99%

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts

Humbert

Fédrizzi

Alexandre

et al. 2019

Sci Rep

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“…It is enough to peruse a few long reviews [1][2][3] to find the relationship of physical activity, smoking, and eating habits with disease and mortality, including the role of mediators between the behaviors and outcome, such as modifiable risk factors. In previous analyses, we showed the role of personal characteristics in predicting long-term mortality, heart diseases, age at death, and longevity in middle-aged men followed up to 50 years [4][5][6][7][8][9][10][11][12][13]. Among the predictors, there were lifestyle behaviors and measurable risk factors, which were frequently included in the same predictive models.…”

Section: Introductionmentioning

confidence: 95%

Canonical Correlation for the Analysis of Lifestyle Behaviors versus Cardiovascular Risk Factors and the Prediction of Cardiovascular Mortality: A Population Study

Menotti,

Puddu

2024

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Objectives: To assess the overall association of lifestyle behaviors with multiple cardiovascular risk factors and mortality. Material and Methods: In the Italian Rural Areas of the Seven Countries Study, involving 1712 middle-aged men (40–59 years) enrolled in 1960, smoking habits, physical activity, dietary habits, marital status, and socioeconomic status (SES) were studied as possible determinants of 15 measurable risk factors (body mass index, tricipital and subscapular skinfold, arm circumference, systolic and diastolic blood pressure, heart rate, double product (systolic blood pressure × heart rate), vital capacity, forced expiratory volume, serum cholesterol, urine protein, urine glucose, corneal arcus and xanthelasma) using canonical correlation (CC). Results: The first CC had a value of 0.54 (R2 0.29, p < 0.0001). The role of marital status was marginal; that of a high SES was contrary to expectations. The strongest behaviors based on standardized CC coefficients were dietary habits and physical activity. The risk factors mostly associated with overall lifestyle behaviors were some anthropometric and cardiovascular measurements. The mean levels of risk factors distributed in tertile classes of the CC variate score of lifestyle behaviors were largely associated in a coherent and graded way with the expected relationship of behaviors versus risk factors. In a large series of Cox models, the CC variate scores were significantly associated with 50-year coronary heart disease (CHD) mortality and much less with stroke and other heart diseases of uncertain etiology. Conclusions: Lifestyle behaviors correlate well with cardiovascular risk factors associated with CHD mortality, and CC is a useful method of analysis to detect long-term impacting characteristics.

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“…We do not completely understand the molecular basis that modulates the aging process, but we have gained remarkable insights into the plasticity of life span and health span from behavioral life-style, genetics and pharmacology of longevity that may open the way toward longer age in good health. Our research group has already used this metrics having the opportunity to exploit data of cohorts close to extinction [5][6][7][8][9]. The use of AD as end-point becomes a must when the populations are extinct since in that case death rates from all-cause are the same in all of them and no comparison is liable.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risk factors predict age at death in 60-year follow-up of the Seven Countries Study

et al. 2022

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Objectives. To study age at death (AD) and its determinants in cohorts of middle-aged men followed-up until extinction.Material and Methods. A total of 9063 middle aged men enrolled in 10 cohorts of 6 countries (USA, Finland, the Netherlands, Italy, Greece and Japan) within the Seven Countries Study were examined and then followed-up for 60 years until extinction. AD was computed and a small number of risk factors were tested through multiple linear regression as possibly related to attained AD.Results. AD ranged across cohorts from 71.8 years in East Finland and 80.5 years in Crete with levels roughly lower in the USA and Northern Europe and higher elsewhere. Across cohorts the correlation coe cients of systolic blood pressure (R=-0.58) and of CVD prevalence (R=-0.65) versus average AD were the only signi cant ones. At individual level in the pool of all cohorts, a multiple linear regression model showed that age, vigorous physical activity, never and ex-smokers were favorably related to AD, while the reverse was true for systolic blood pressure, heart rate, serum cholesterol, CVD prevalence and silent ECG abnormalities. BMI had a parabolic relationship with AD. The predicting power of single risk factors, expressed in years gained or lost, was relatively small, but arbitrary combinations of several of them produced large differences in AD.Conclusions. A small number of CVD risk factors were strongly associated with AD in a life-long follow-up.

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Age at death as a useful indicator of healthy aging at population level: a 50-year follow-up of the Italian Rural Areas of the Seven Countries Study

Abstract: AD proved to be a useful indicator of previous health and aging of populations. HDUE and SNUNK seem the most "physiological" causes of death. SBP and lifestyle risk factors are the most relevant characteristics associated with AD.

Cited by 12 publications

References 15 publications

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts

Impact of Sex on Office White Coat Effect Tail: Investigating Two Italian Residential Cohorts

Canonical Correlation for the Analysis of Lifestyle Behaviors versus Cardiovascular Risk Factors and the Prediction of Cardiovascular Mortality: A Population Study

Cardiovascular risk factors predict age at death in 60-year follow-up of the Seven Countries Study

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