2000
DOI: 10.1016/s0047-6374(00)00158-5
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Age-associated DNA damage is accelerated in the senescence-accelerated mice

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Cited by 33 publications
(11 citation statements)
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“…Uryvaeva et al (1999) have shown an accelerated accumulation of micronuclear aberrations with age in the liver cells of SAMP mice as compared to the SAMR strain. The ageassociated incidence of somatic Hprt mutations in splenic lymphocytes, as well as DNA damage (mainly DNA single strand breaks) in six organs, are also accelerated in SAMP-1 mice as compared to the SAMR-1 (Odagiri et al, 1998;Hosokawa et al, 2000).…”
Section: Discussionmentioning
confidence: 96%
“…Uryvaeva et al (1999) have shown an accelerated accumulation of micronuclear aberrations with age in the liver cells of SAMP mice as compared to the SAMR strain. The ageassociated incidence of somatic Hprt mutations in splenic lymphocytes, as well as DNA damage (mainly DNA single strand breaks) in six organs, are also accelerated in SAMP-1 mice as compared to the SAMR-1 (Odagiri et al, 1998;Hosokawa et al, 2000).…”
Section: Discussionmentioning
confidence: 96%
“…Short-living BDF1, SAMP6/Tan and A/J mice showed a significant agerelated increase in spontaneous frequencies of micronucleated reticulocytes whereas long-living ddY, CD-1, B6C3F1, SAMR1, and MS/Ae did not show significant age-related differences in mean frequencies of spontaneous micronuclei [234]. Long-live mutant Ames dwarf mice and knockout p66 she(/( mice were less vulnerable to oxidative damage than wild-type controls [228,235], whereas senescence-prone strain, SAMP, had increased production of ROS [207], DNA damages and somatic mutation as compared with senescence-resistant SAMR strain [236]. MGMT-overexpressed mice are more resistant to alkylating agents [199,237], whereas deficient in DNA repair MGMT (/( and Parp (/( mice are more susceptible to effect of alkylating chemicals and ionizing radiation [218,238].…”
Section: Effect Of Genetic Modifications Of Aging On Carcinogenesismentioning
confidence: 87%
“…SAMP strains show markedly shorter average life span compared with SAMR. The SAMP1 mice exhibited increased chromosome aberration (74), mutation of hprt genes (74), and the strong correlation of DNA damage and aging process (75). Therefore, we used SAMP1 and SAMR1 for our experiments.…”
Section: Animals and Tissue Preparationmentioning
confidence: 99%