Age-associated difference in circadian sleep–wake and rest–activity rhythms

Huang, Yonglu; Liu, Rong‐Yu; Wang, Qingsong; Someren, Eus J.W. Van; Xu, Hao; Zhou, Jiang‐Ning

doi:10.1016/s0031-9384(02)00733-3

Cited by 248 publications

(204 citation statements)

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“…Moreover, a recent study demonstrated that thermoregulation differed according to photoperiod and age in this species , see comments in (Van Someren, 2007). Several of these studies indicate that daily and seasonal biological rhythms are altered in old mouse lemurs in ways that are remarkably similar to what is observed in human aging (Huang et al, 2002;Cayetanot et al, 2005): a decrease in amplitude of the locomotor activity level, an increased activity during the resting diurnal phase and an increase in fragmentation. For these and other reasons, the mouse lemur can be regarded as a model of primary importance for human aging (Bons et al, 2006).…”

Section: Introductionmentioning

confidence: 84%

“…Actograms were performed using the Clocklab software (Actimetrics Inc., Evanston, IL). Quantitative characteristics of the locomotor activity rhythm were determined with non-parametric methods as previously described (Van Someren et al, 1999;Huang et al, 2002). Briefly, the following variables were calculated from the locomotor activity data.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, aging modifies the daily rhythm of restactivity. Aging is typically associated with (1) an increased fragmentation into shorter alternating periods of rest and activity; (2) an increased activity level during the major sleep period, (3) a decreased activity level during the major active period, and as a consequence (4) a decreased amplitude (Witting et al, 1990;Myers and Badia, 1995;Huang et al, 2002). The amplitude, pattern and phasing of the 24-hour profile of body temperature also changes with aging (Monk et al, 1995;Duffy et al, 1998;Gubin et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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To cite this version:Fabienne Aujard, Florence Cayetanot, Jérémy Terrien, Eus J.W. Van Someren. Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate. Experimental Gerontology, Elsevier, 2007, 42 (11) ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ABSTRACTAdaptation of physiological and behavioral functions to seasonal changes in daylength is of major relevance for optimal fitness and survival. Because aging is characterized by changes in biological rhythms, it may be hypothesized that old animals fall short of showing a full adaptation to prolonged changes in the duration of daily light exposure, as naturally occurring in relation to season in younger individuals. To test this hypothesis, we analyzed changes in the patterns of daily locomotor activity and body temperature rhythms of young and old mouse lemurs (Microcebus murinus, Primates) exposed to short and long daylengths. The effect of an increase in the duration of daily light exposure was attenuated in old animals, as compared to younger lemurs. Although some age-related differences in the locomotor activity rhythm could be seen under exposure to short daylength, they were predominant under long daylength. Some mechanisms allowing adaptation to changing day length thus seem to be impaired at old age. Changes in coupling of circadian oscillators to the light-dark cycle and disturbances in the physiological responses to change in light duration should be further investigated.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Aujard

Cayetanot

Terrien

et al. 2007

Experimental Gerontology

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“…Aging is a very complex process that is related to circadian rhythm disruption and produces sleep disturbances (Huang et al 2002) and other physiological or psychological dysfunctions (Barnard and Nolan 2008) including impaired nutrient absorption (Meier and Sturm 2009;Woudstra and Thomson 2002), immunosenescence (Canizzo et al 2011;Hutt et al 2010;Ortega et al 2000), decrease in hormone levels (Ferrari and Magri 2008), or neuronal death (Shankar 2010;Qureshi and Parvez 2007). Adequate daily sleep is an important part of a healthy and productive lifestyle.…”

Section: Introductionmentioning

confidence: 99%

“…Oldest groups are especially prone to impaired sleep (Huang et al 2002). Nocturnal sleep is an active physiologic process that seems to contribute to the neutralization of free radicals through immune system (Paredes et al 2009a), consolidates memory (Maquet et al 2010), and reconstitutes body tissues ).…”

Section: Introductionmentioning

confidence: 99%

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Bravo

Matito²,

Juánez

et al. 2012

AGE

149

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Melatonin and serotonin rhythms, which exhibit a close association with the endogenous circadian component of sleep, are attenuated with increasing age. This decrease seems to be linked to sleep alterations in the elderly. Chrononutrition is a field of chronobiology that establishes the principle of consuming foodstuffs at times of the day when they are more useful for health, improving, therefore, biorhythms and physical performance. Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay. Data were collected for 3 weeks according to the following schedule: The control week participants consumed standard cereals (22.5 mg tryptophan in 30 g cereals per dose) at breakfast and dinner; for the treatment week, cereals enriched with a higher dose of tryptophan (60 mg tryptophan in 30 g cereals per dose) were eaten at both breakfast and dinner; the posttreatment week volunteers consumed their usual diet. Each participant wore a wrist actimeter that logged activity during the whole experiment. Urine was collected to analyze melatonin and serotonin urinary metabolites and to measure total antioxidant capacity. The consumption of cereals containing the higher dose in tryptophan increased sleep efficiency, actual sleep time, immobile time, and decreased total nocturnal activity, sleep fragmentation index, and sleep latency. Urinary 6-sulfatoxymelatonin, 5-hydroxyindoleacetic acid levels, and urinary total antioxidant capacity also increased respectively after tryptophan-enriched cereal ingestion as well as improving anxiety and depression symptoms. Cereals enriched

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Function and Pharmacology of Circadian Clocks

Lundkvist

Block

2007

Handbook of Contemporary Neuropharmacology

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Biological timing systems are complex structures in higher organisms, generating biological and physiological functions with a periodicity of approximately 24 h. Knowledge of the structure and function of biological clocks has emerged from research on both invertebrate and vertebrate models. In humans, the master clock is located in the hypothalamus in the brain. Daily rhythms such as the sleep–wake cycle and hormonal rhythms can be modulated and disturbed by a number of pharmacological compounds. Drug therapy can be administered in a circadian fashion ( chronopharmacology ), thus taking into account the powerful circadian impact on drug toxicity and efficacy. This review will describe circadian systems and pharmacological impact on the timing structures.

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Age-associated difference in circadian sleep–wake and rest–activity rhythms

Cited by 248 publications

References 25 publications

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Attenuated effect of increased daylength on activity rhythm in the old mouse lemur, a non-human primate

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Function and Pharmacology of Circadian Clocks

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