Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants

Mohsen, Manal M Abd El; Iravani, Mahmoud M.; Spencer, Jeremy P.E.; Rose, Sarah; Fahim, Atef T.; Motawi, Tarek K.; Ismail, Nagwa Abdallah; Jenner, Peter

doi:10.1016/j.bbrc.2005.07.201

Cited by 83 publications

(47 citation statements)

References 27 publications

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“…All of these may be attenuated by chronic treatment with dietary melatonin [79][80][81][82][83]. Melatonin can restore the ability of the aging brain to respond to an inflammatory stimulus [19], and this is in concordance with reports of favorable effects of melatonin on the circulating immune system (described earlier).…”

Section: Specific Effects Of Melatonin On Events Relating To Brain Agingsupporting

confidence: 81%

Melatonin, Oxidative Stress, and the Aging Brain

Bondy

Sharman

2010

Aging and Age-Related Disorders

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The changes associated with brain aging are discussed with emphasis on altered oxidative and inflammatory events and on mitochondrial dysfunction. Many of these changes are exacerbated in a variety of age-related neurologic diseases. This commonality has led to the idea that similar therapeutic approaches may be used in the treatment of several apparently unrelated neurodegenerative disorders. When aspects of these diseases are modeled in experimental animals and cell lines, the application of melatonin has been reported to be advantageous. The means by which melatonin can be protective probably is mediated by way of activation of melatonin receptors, of which several subtypes can be identified. This can initiate a sequence of intracellular signaling events and by activation of transcription factors lead to altered gene expression. The culmination of this cascade can lead to increased levels of antioxidant enzymes and depressed levels of inflammation. Melatonin may be useful both in the retardation of nonpathologic brain aging and in the amelioration of chronic brain disease associated with aging. The inexpensive nature and ready availability of melatonin together with its very low toxicity reinforce the need to place the beneficial properties of this agent on a firmer basis.

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Section: Specific Effects Of Melatonin On Events Relating To Brain Agingsupporting

confidence: 81%

Melatonin, Oxidative Stress, and the Aging Brain

Bondy

Sharman

2010

Aging and Age-Related Disorders

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“…In fact, contradictory data have been observed with regard to decreased proteasome activity in the rodent brain. While Abd El Mohsen et al [80] reported that the proteasomal activity was not affected by age in any region of the brain of male rats, Zeng et al [81] have reported a decrease of the proteasomal activity in brains of rats and mice. The proteasome activity declines in the human lens due to aging [82] .…”

Section: Proteolysis Of Oxidized Proteins By Proteasomes and Agingmentioning

confidence: 99%

Oxidative Modification of Proteins: Age-Related Changes

Chakravarti¹,

Chakravarti²

2006

Gerontology

154

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Aging is a complex biological phenomenon which involves progressive loss of different physiological functions of various tissues of living organisms. It is the inevitable fate of life and is a major risk factor for death and different pathological disorders. Based on a wide variety of studies performed in humans as well as in various animal models and microbial systems, reactive oxygen species (ROS) are believed to play a key role in the aging process. The production of ROS is influenced by cellular metabolic activities as well as environmental factors. ROS can react with all major biological macromolecules such as carbohydrates, nucleic acids, lipids, and proteins. Since, in general, proteins are the key molecules that play the ultimate role in various structural and functional aspects of living organisms, this review will focus on the age-related oxidative modifications of proteins as well as on mechanism for removal or repair of the oxidized proteins. The topics covered include protein oxidation as a marker of oxidative stress, experimental evidence indicating the role of ROS in protein oxidation, protein carbonyl content, enzymatic degradation of oxidized proteins, and effects of caloric restriction on protein oxidation in the context of aging. Finally, we will discuss different strategies which have been or can be undertaken to slow down the oxidative damage of proteins and the aging process.

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“…All of these changes may be partially prevented by extended melatonin treatment (Matsubara et al, 2003;Bondy et al, 2004;Dupuis et al, 2004;Lahiri et al, 2005;Abd El Mohsen et al, 2005). Melatonin can restore the ability of the aging brain to respond to an inflammatory stimulus (Sharman et al, 2002a).…”

Section: Melatonin and Deficits Associated With Brain Agingmentioning

confidence: 99%

Melatonin and the aging brain

Bondy

Sharman

2007

Neurochemistry International

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The events associated with brain aging are enumerated with emphasis on increased oxidative and inflammatory processes and on mitochondrial dysfunction. Several of these factors are further increased in a wide range of overt age-related neurological diseases. This generality has given impetus to concepts concerning similar therapeutic approaches common to a series of neurodegenerative disorders. Animal and cell culture models of several such disorders have benefited from the application of melatonin. The mechanisms underlying the neuroprotective properties of melatonin are likely to involve activation of specific melatonin receptors. This can lead to modulation of transcription factors and consequent altered gene expression, resulting in enhancement of antioxidant enzymes and downregulation of basal levels of inflammation. Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions. This is reinforced by the low cost of melatonin and its very low toxic hazard. #

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Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants

Cited by 83 publications

References 27 publications

Melatonin, Oxidative Stress, and the Aging Brain

Melatonin, Oxidative Stress, and the Aging Brain

Oxidative Modification of Proteins: Age-Related Changes

Melatonin and the aging brain

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