Age-associated changes in nicotine dependence

Park, Susan; Lee, J.-Y.; Song, Tae Min; Cho, S.-I.

doi:10.1016/j.puhe.2012.02.007

Cited by 47 publications

(37 citation statements)

References 33 publications

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“…In contrast, both acetaldehyde (in adolescents) and tranylcypromine (in adults) increased responding far beyond the peak of nicotine alone (Belluzzi et al, 2005;Villégier et al, 2007), similar to effects seen in other labs with nicotine Self-administration of cigarette smoke extract MR Costello et al alkaloids (Clemens et al, 2009). However, smokers typically titrate their cigarette intake and will maintain a steady level of use for many years (Park et al, 2012). Our results are therefore consistent with human data, in that CSE is quite potent but not as reinforcing as other drugs of abuse.…”

Section: Discussionsupporting

confidence: 88%

Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats

Costello

Reynaga

Mojica

et al. 2014

Neuropsychopharmacol

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Tobacco dependence is difficult to treat, with the vast majority of those who try to quit relapsing within the first year. Improvements in smoking cessation therapies may be achieved by improving current preclinical research methods. However, most experimental tests in animals use nicotine alone, ignoring the 8000 other constituents found in tobacco smoke. To improve on this model, we have used selfadministration to test the reinforcing properties of aqueous cigarette smoke extract (CSE) in rats, made by bubbling cigarette smoke through a saline solution. CSE is more potent than nicotine alone in both the acquisition and maintenance of self-administration, but did not exhibit higher progressive ratio responding. Mecamylamine and varenicline had similar potencies to block nicotine and CSE selfadministration, indicating the involvement of nicotinic receptors in CSE reinforcement. Following extinction of responding, reinstatement was triggered by exposing animals to a pharmacological stressor, yohimbine (2.5 mg/kg, i.p.), alone and in combination with cues. Animals that self-administered CSE were significantly more sensitive to stress-induced reinstatement than those that self-administered nicotine. Ligand binding autoradiography studies showed nicotine and CSE to have similar affinities for different nicotinic receptor types. CSE significantly reduced MAO-A and MAO-B activities in vitro, whereas nicotine did not. Although CSE inhibition of MAO-A activity in vitro was found to be partially irreversible, irreversible inhibition was not observed in vivo. These experiments show that CSE is an effective reinforcer acting via nicotinic receptors. Furthermore, it better models MAO inhibition and is more sensitive to stress-induced reinstatement than nicotine alone, which is a potent trigger for relapse in smokers.

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Section: Discussionsupporting

confidence: 88%

Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats

Costello

Reynaga

Mojica

et al. 2014

Neuropsychopharmacol

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“…Um estudo realizado durante 10 anos, com um grupo de 1.520 adolescentes entre os 14-15 anos, demonstrou que 50% dos participantes que iniciaram o consumo de tabaco na adolescência se mantiveram fumadores na idade adulta 33 . Park et al 34 concluíram que o tabagismo e a dependência da nicotina se iniciam aos 20 anos.…”

Section: Discussão Dos Resultadosunclassified

Desigualdades socioeconómicas no tabagismo em jovens dos 15 aos 17 anos

Cristina

Alves

Perelman

2016

Revista Portuguesa de Saúde Pública

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“…These findings support previous studies linking co-use and nicotine dependence in adolescents and young adults (Ramo and Prochaska, 2012; Ramo et al, 2013, 2012) and add to preliminary data that this association was also stable in adults (Wang and Cataldo, 2016) and, surprisingly, particularly robust in 50–64 year old adults. These findings reflect evidence of a U-shaped effect between age and nicotine dependence which peaks at age 50 years due to changes in nicotinic receptors and nicotine-associated metabolism with age (Park et al, 2012), and suggest that this relationship was stable among co-users. Studies are needed to determine the extent to which THC exposure and/or current marijuana use add to this effect (if at all).…”

Section: Discussionmentioning

confidence: 52%

“…The relationship between co-use and nicotine dependence, however, is understudied in adults, particularly among those ages 50 years and older. Since nicotine dependence is influenced by both nicotinic receptors and nicotine-associated metablism that change with age (Park et al, 2012), we can expect nicotine dependence among cigarette and marijuana co-users will also vary over the lifespan. Few studies have examined cigarette and marijuana co-use and nicotine dependence from adolescence through adulthood.…”

Section: Introductionmentioning

confidence: 99%

Medical marijuana legalization and cigarette and marijuana co-use in adolescents and adults

Wang

Ramo

Lisha

et al. 2016

Drug and Alcohol Dependence

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Background Medical marijuana legalization is associated with a higher prevalence of marijuana use which may affect cigarette use and nicotine dependence in co-users. In the present study, we examined relationships between statewide legalization of medical marijuana and prevalence of cigarette and marijuana co-use and nicotine dependence in co-using adolescents and adults. Methods Data were analyzed from the 2013 National Survey on Drug Use and Health. We compared cigarette and marijuana co-use in the past 30 days across age categories (12–64 years) by statewide medical marijuana legalization. Logistic regression models were used to estimate the odds of having nicotine dependence among current cigarette smokers who also reported past 30-day marijuana use and “ever but not current” marijuana use (vs. “never” use) adjusting for covariates including statewide legalization of medical marijuana. Results Overall, 5.1% of the sample reported past 30-day cigarette and marijuana co-use and a higher proportion of co-users resided in states where medical marijuana was legal compared to illegal (5.8% vs. 4.8%; p=.0011). Co-use was associated with greater odds of having nicotine dependence compared to cigarette-only use across age categories. Odds were highest and up to 3-times higher in adolescents aged 12–17 years (OR=3.54; 95%CI: 1.81–6.92) and adults aged 50–64 years (OR=3.08; CI: 1.45–6.55). Conclusion Marijuana policy could inadvertently affect cigarette and marijuana co-use and pose challenges to tobacco cessation.

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Age-associated changes in nicotine dependence

Cited by 47 publications

References 33 publications

Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats

Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats

Desigualdades socioeconómicas no tabagismo em jovens dos 15 aos 17 anos

Medical marijuana legalization and cigarette and marijuana co-use in adolescents and adults

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