Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice
Harini Bagavant,
Justyna Durslewicz,
Marcelina Pyclik
et al.
Abstract:Sjögren's disease (SjD), characterized by circulating autoantibodies and exocrine gland inflammation, is typically diagnosed in women over 50 years of age. However, the contribution of age to SjD pathogenesis is unclear. C57BL/6 female mice at different ages were studied to investigate how aging influences the dynamics of salivary gland inflammation. Salivary glands were characterized for immune cell infiltration, inflammatory gene expression, oxidative stress, and saliva production. At 8 months, gene expressi… Show more
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