Age as a risk factor for acute mountain sickness upon rapid ascent to 3,700 m among young adult Chinese men

Tang, Xu-gang; Zhang, Jihang; Qin, Jun; Gao, Xubin; Li, Qian-ning; Yu, Jie; Ding, Xiaoyan; Huang, Lan

doi:10.2147/cia.s67052

Cited by 15 publications

(18 citation statements)

References 24 publications

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“…In contrast, exclusion of the study by You et al 31 increased the pooled OR to 0.92 (95% CI = 0.78-1.09). When we calculated the pooled OR based on the four studies available that provided the results of multivariate risk modeling including smoking , 25,35,36,38 this was a weakly positive (11% increase) risk factor for AMS with wide confidence intervals (OR = 1.13; 95% CI = 0.53-2.41).…”

Section: Resultsmentioning

confidence: 99%

Is Smoking a Predictor for Acute Mountain Sickness? Findings From a Meta-Analysis

Vinnikov

Blanc

Steinmaus

2015

NICTOB

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This is the first quantitative assessment of published studies on smoking and AMS, which shows smoking to be neither a risk, nor protective. Studies specifically focusing on smoking as a risk factor, should guide further research on this issue. Although all smokers should be strongly advised to quit, studies on risk factors for AMS focusing on other exposures could shed light on the full range of risks for AMS.

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Section: Resultsmentioning

confidence: 99%

Is Smoking a Predictor for Acute Mountain Sickness? Findings From a Meta-Analysis

Vinnikov

Blanc

Steinmaus

2015

NICTOB

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“…However, these studies reported different results. Tang et al [ 49 ] suggested that the elderly were more sensitive to AMS, whereas Hackett et al [ 2 , 22 , 32 ] reported opposite findings, suggesting that older age is protective against AMS. In addition, some studies indicated that age has no relationship with AMS.…”

Section: Discussionmentioning

confidence: 99%

Association between acute mountain sickness (AMS) and age: a meta-analysis

Zhang

Chen

et al. 2018

Military Med Res

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BackgroundAcute mountain sickness (AMS) is a potentially lethal condition caused by acute hypoxia after ascending to altitudes higher than 2500 m in a short time. The main symptom of AMS is headache. Numerous risk factors of AMS have been examined, including gender, obesity, ascent rate, age and individual susceptibility. In previous studies, age was considered a predisposing factor for AMS. However, different opinions have been raised in recent years. To clarify the association between AMS and age, we conducted this meta-analysis.MethodsWe obtained observational studies that explored risk factors for AMS by searching PubMed, Embase, China National Knowledge Internet (CNKI), the Wanfang database and CQVIP for articles published before March 2017. The studies included were required to provide the mean age and its standard deviation for subjects with and without AMS, the maximum altitude attained and the mode of ascent. The Lake Louse Score (LLS) or the Chinese AMS score (CAS) was used to judge the severity of AMS symptoms and incidence. Studies were pooled for the analysis by using a random effects model in RevMan 5.0. Meta-regression and subgroup analyses were conducted to identify sources of heterogeneity using Stata 14.2 and RevMan 5.0.ResultsIn total, 17 studies were included, and the overall number of subjects with and without AMS was 1810 and 3014, respectively. The age ranged from 10 to 76 years. Analysis of the 17 included studies showed that age was not associated with AMS (mean difference (MD) = 0.10; 95% CI: -0.38-0.58; P = 0.69).ConclusionThis meta-analysis suggests that there is no association between age and the risk of AMS. Race, age, and ascent mode are common sources of heterogeneity, which may provide an analytical orientation for future heterogeneity analyses.

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“…Previous studies have attempted to identify risk factors that can be used to predict AMS susceptibility. A substantial number of studies have shown that age [8, 9], body mass index (BMI) [9, 10], arterial oxygen saturation [11], sleep quality [12] and gender [13, 14] are correlated with AMS susceptibility. However, other studies have found that these factors do not play a role in AMS development [15].…”

Section: Introductionmentioning

confidence: 99%

Association between smoking and the risk of acute mountain sickness: a meta-analysis of observational studies

Wang

et al. 2016

Military Med Res

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BackgroundPeople rapidly ascending to high altitudes (>2500 m) may suffer from acute mountain sickness (AMS). The association between smoking and AMS risk remains unclear. Therefore, we performed a meta-analysis to evaluate the association between smoking and AMS risk.MethodsThe association between smoking and AMS risk was determined according to predefined criteria established by our team. Meta-analysis was conducted according to the PRISMA guidelines. We included all relevant studies listed in the PubMed and Embase databases as of September 2015 in this meta-analysis and performed systemic searches using the terms “smoking”, “acute mountain sickness” and “risk factor”. The included studies were required to provide clear explanations regarding their definitions of smoking, the final altitudes reached by their participants and the diagnostic criteria used to diagnose AMS. Odds ratios (ORs) were used to evaluate the association between smoking and AMS risk across the studies, and the Q statistic was used to test OR heterogeneity, which was considered significant when P < 0.05. We also computed 95% confidence intervals (CIs). Data extracted from the articles were analyzed with Review Manager 5.3 (Cochrane Collaboration, Oxford, UK).ResultsWe used seven case-control studies including 694 smoking patients and 1986 non-smoking controls to analyze the association between smoking and AMS risk. We observed a significant association between AMS and smoking (OR = 0.71, 95% CI 0.52–0.96, P = 0.03).ConclusionsWe determined that smoking may protect against AMS development. However, we do not advise smoking to prevent AMS. More studies are necessary to confirm the role of smoking in AMS risk.

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Age as a risk factor for acute mountain sickness upon rapid ascent to 3,700 m among young adult Chinese men

Cited by 15 publications

References 24 publications

Is Smoking a Predictor for Acute Mountain Sickness? Findings From a Meta-Analysis

Is Smoking a Predictor for Acute Mountain Sickness? Findings From a Meta-Analysis

Association between acute mountain sickness (AMS) and age: a meta-analysis

Association between smoking and the risk of acute mountain sickness: a meta-analysis of observational studies

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