Age and Survival of Cervical Cancer Patients with Bone Metastasis

Nartthanarung, Adisak; Thanapprapasr, Kamolrat; Udomsubpayakul, Umaporn; Thanapprapasr, Duangmani

doi:10.7314/apjcp.2014.15.19.8401

Cited by 20 publications

(26 citation statements)

References 16 publications

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“…Primary intention should be prevention or early diagnosis, and screening programs constitute be the main focus. It is well known that the incidence of cervical cancer increases with age (Nartthanarung et al, 2014). In the present study, 78% of the patients were 65 years or older (Table 1).…”

Section: Discussionmentioning

confidence: 65%

Effect of Hydronephrosis on Survival in Advanced Stage Cervical Cancer

Goklu

Seçkin²,

Toğrul³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Hydronephrosis is frequently encountered in advanced stage cervical cancers, and may be associated with mortality. In the present study, we aimed to demonstrate the effect of hydronephrosis on survival in patients with inoperable advanced stage cervical cancer. Materials and Methods: The study data were acquired by retrospective analysis of the patient records belonging to 165 women with FIGO (International Federation of Gynecology and Obstetrics) stage-IIIB or more advanced cervical cancer, which were not surgical candidates. Parameters including patient age, pathological diagnosis, disease stage, pelvic sidewall extension, presence of hydronephrosis and administration of chemoradiation were analyzed. Further, the effects of these variables on survival were assessed. P values less than 0.05 were considered statistically significant. Results: The distribution of the study patients according to disease stage was as follows: 131 (79.4%) had stage-IIIB, 18 (10.9%) had stage-IVB and 16 (% 9.7) patients had stage-IVA disease. Hydronephrosis was not evident in 91 (55.2%) of these patients, whereas 41 (24.8%) had unilateral and 33 (20%) patients had bilateral hydronephrosis. When compared to mean survival in patients who did not have hydronephrosis, survival was significantly shortened in patients who had bilateral and unilateral hydronephrosis (p < 0.05). There was no significant survival difference between patients with unilateral and bilateral hydronephrosis (p>0.05). Although patient age, pathological type, pelvic involvement, and chemotherapy treatment rates were similar (p>0.05), radiotherapy requirement rate and disease stage were significantly different among the study groups (p<0.05). Conclusions: Hydronephrosis was found to be a significant predictor of poor survival in patients with advanced stage cervical cancer, irrespective of unilateral or bilateral involvement.While waiting for future studies with larger sample sizes, we believe that the FIGO stages in advanced cervical cancer could further be stratified into subgroups according to presence or absence of hydronephrosis.

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Section: Discussionmentioning

confidence: 65%

Effect of Hydronephrosis on Survival in Advanced Stage Cervical Cancer

Goklu

Seçkin²,

Toğrul³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Married patients may have better support from their family after tumor diagnosis, as is depression and stress have been reported to be significantly associated with tumor metastases [ 28 , 29 ]. Married patients may have lower opportunity to be infected by human papillomavirus (HPV), which is the main cause of cervical cancer [ 16 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been previously reported that patients with cancer of the uterine cervix who present at under 45 years had shorter overall survival compared with older patients [ 16 ]. However, contrary to this previous report, we found no significant correlation between age and overall survival when age was stratified into three subgroups.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is a need to study the prognostic factors for bone metastases and provide proper treatment to the high-risk patients with cervical cancer [ 15 ]. A previously published study that included 68 patients with cancer of the uterine cervix also showed that when compared with elderly patients, young patients with bone metastases who were aged less than 45 years, had a poorer prognosis [ 16 ]. It has also been reported that patients with cancer of the uterine cervix who have a higher tumor TNM stage and several sites for bone metastases had a worse survival rate [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Real-World Study of the Incidence, Risk Factors, and Prognostic Factors Associated with Bone Metastases in Women with Uterine Cervical Cancer Using Surveillance, Epidemiology, and End Results (SEER) Data Analysis

et al. 2018

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BackgroundThe aims of this study were to investigate the incidence and risk factors for the development of bone metastases and prognosis in women with cancer of the uterine cervix using database analysis.Material/MethodsThe National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) database was analyzed for the incidence and survival rates of women diagnosed with uterine cervical cancer in the United States between 2010–2015. Multivariate logistic regression analysis identified risk factors for bone metastases. Kaplan-Meier analysis estimated the overall survival. Proportional hazard regression analysis estimated prognostic factors associated with bone metastases.ResultsThere were 19,363 women with uterine cervical cancer, and 469 women were diagnosed with bone metastases on initial diagnosis (2.42%). Increased T-stage, N-stage, non-squamous and non-adenocarcinoma histology, high-grade tumors, and the presence of lung, liver, and brain metastases were all significantly associated with early bone metastases. There were 364 patients with cervical cancer and bone metastases on initial diagnosis who were followed-up for at least one year. Multivariate Cox regression analysis showed that unmarried status and lung, liver, and brain metastases were significantly associated with reduced overall survival. No other significant risk or prognostic associations were found.ConclusionsSEER data analysis showed that women with uterine cervical cancer had some standard risk factors associated with bone metastases, and with prognosis, but a heterogeneous group of risk factors was also present. The findings of this study may have clinical application in screening for bone metastases in women with cervical cancer.

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“…In general, cervical cancer can spread to adjacent organs including the vagina, peritoneum, urinary bladder, ureters, rectum, and paracervical tissue. Meanwhile, Common distant metastatic sites include the lungs, bones, and liver [ 6 ], but cervical cancer metastases to the small intestine and sigmoid colon are rare. Here, we present the first reported case of a cervical cancer patient with simultaneous metastases to the small intestine and sigmoid colon, based on our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Postoperation of cervical cancer with intestine metastasis: a case report and literature review

Wang

Zhang

et al. 2015

World J Surg Onc

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BackgroundCervical cancer can infiltrate locally and directly spread to adjacent organs including the vagina, peritoneum, urinary bladder, ureters, rectum, and paracervical tissue, but the intestine metastasis from cervical cancer is extremely rare, which can easily be misdiagnosed.Case presentationHere, we report a case about a 45-year-old postoperative cervical cancer patient with metastases to small intestine and sigmoid colon who presented abdominal distention and dull pain due to intestinal obstruction. The patient underwent exploratory laparotomy, and two intestinal segments including the tumors were resected. The postoperative pathological diagnosis illustrated sigmoid colon and terminal ileum metastatic squamous cell carcinoma.ConclusionsThis case demonstrates that intestine metastasis must be considered in the differential diagnosis of acute abdomen in patients with cervical cancer even at an early tumor stage.

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Age and Survival of Cervical Cancer Patients with Bone Metastasis

Cited by 20 publications

References 16 publications

Effect of Hydronephrosis on Survival in Advanced Stage Cervical Cancer

Effect of Hydronephrosis on Survival in Advanced Stage Cervical Cancer

Real-World Study of the Incidence, Risk Factors, and Prognostic Factors Associated with Bone Metastases in Women with Uterine Cervical Cancer Using Surveillance, Epidemiology, and End Results (SEER) Data Analysis

Postoperation of cervical cancer with intestine metastasis: a case report and literature review

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