Age and stage dependency of P300 latency alterations in non-demented Parkinson's disease patients without therapy

Stanzione, Paolo; Semprini, Roberta; Pierantozzi, Mariangela; Santilli, Antonella; Fadda, Lucia; Traversa, R.; Peppe, Antonella; Bernardi, Giorgio

doi:10.1016/s0168-5597(97)00070-1

Cited by 35 publications

(20 citation statements)

References 59 publications

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“…Our findings support the study 18 which describes the age as a factor strongly related to P300 latencies in PD and for this reason, we believe that comparisons between groups of subjects should consider more restricted age groups. While we observed latency prolongation related to the severity of the disease in elderly people over 65 years old, we also verified that in younger subjects there is no significant retardation in the generation of the potential even in more severe PD clinical features.…”

Section: Discussionsupporting

confidence: 91%

“…On the other hand, in the early stages of PD, cognitive impairment is slight and less prevalent 21,22 , this could explain the reduced number of subjects in this stage with delayed P300 latencies. As well as in other studies 7,18 , we observed that P300 latency does not correlate with motor function when evaluated in details by UPDRS part III. This piece of information is suitable with the fact that there are different dopaminergic pathways related to motor and mental impairment in PD 23 , emphisizing that dopaminergic areas are also involved in cognitive decline 20,16 .…”

Section: Discussionsupporting

confidence: 86%

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Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients

Lopes

Melo

Nóbrega

2014

Arq. Neuro-Psiquiatr.

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Electrophysiological methods could provide important information about the neurophysiological status in Parkinson's disease (PD).Objective: To investigate the prolonged auditory P300 latency in PD and its association with the disease clinical stage. Method: Clinical profiles of 44 patients were evaluated and those in initial and advanced stages of PD were identified. The frequency of altered latencies, median of latencies in each stage, and correlation between latencies and motor and non-motor clinical features were analyzed. Latencies were considered altered when they were more than two standard deviations from the mean of controls, per age group. Results: It was verified 10% of alterations in initial stages and 31% in advanced. There was correlation between latencies and non-motor clinical features. Subjects older than 65, in advanced stages, presented a significant increase of latencies. Conclusion: There was an association between PD severity and P300 prolonged latencies among subjects 65 years old or older.Keywords: P300 component, idiopathic Parkinson's disease, aging, auditory event-related potentials. RESUMO Exames eletrofisiológicos podem fornecer informações sobre o status neurofisiológico na doença de Parkinson (DP).Objetivo: Investigar o prolongamento das latências do P300 auditivo na DP e sua associação com o estágio da doença. Método: Foi avaliado o quadro clínico de 44 pacientes e identificados aqueles em estágio inicial e avançado da DP. Analisou-se a frequência de latências alteradas, mediana das latências em cada estágio e a correlação entre latências e quadro clínico motor e não motor da DP. As latências foram consideradas alteradas quando superiores a dois desvios-padrão da média dos controles, por grupo etário. Resultados: Verificaram-se 10% de alterações no estágio inicial e 31% no avançado. Houve correlação entre as latências e o quadro clínico não motor. Sujeitos com mais de 65 anos, em estágio avançado, apresentaram significativo aumento das latências. Conclusão: Existe associação entre gravidade da DP e prolongamento das latências do P300 nos sujeitos acima de 65 anos.Palavras-chave: P300, doença de Parkinson idiopática, envelhecimento, potenciais evocados auditivos relacionados a eventos.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients

Lopes

Melo

Nóbrega

2014

Arq. Neuro-Psiquiatr.

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“…Specifically, P3b latency appears to be related to prototypical executive functions such as set-shifting (Iijima et al, 2000;Katsarou et al, 2004;Stamenović et al, 2005; but see Stanzione et al, 1998), trail-making (Matsui et al, 2007;Stamenović et al, 2005; but see Elwan et al, 1996), verbal fluency (BodisWollner et al, 1995;Chen et al, 2006), working memory (O'Donnell et al, 1987), and planning (Kim et al, 1995), even in non-demented patients. However, to date it is not clear whether the association between P3b latency and executive functioning in PD is actually specific, because previous studies did not control for the variance shared with measures of global cognitive ability.…”

Section: P3b and The Specificity Of Cognitive Changes In Pdmentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Так, P. Stanzione и соавт. [22] выявили зависимость латентности пика Р300 слуховых потенциалов от возраста испытуемых и стадии болезни. В работе M. Lopes и соавт.…”

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Event-related potentials in Parkinson’s disease

Veryugina¹,

Glozman

Васенина³

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Хотя когнитивные нарушения не являются начальным симптомом болезни Паркинсона (БП), по мере прогрессирования заболевания они постепенно развиваются и могут достичь степени деменции. Метод когнитивных вызванных потенциалов с оценкой волны Р300 чувствителен к когнитивным нарушениям, в связи с чем его применяют для оценки когнитивных функций при БП. Несмотря на то что во многих исследованиях выявлены корреляционные связи латентности и амплитуды Р300 с когнитивными функциями при БП, существует значительное число и противоположных результатов. В статье представлен их обзор. Авторы считают, что рассматриваемый метод должен применяться только в сочетании с клиническим и нейропсихологическим исследованиями и требует дальнейшего изучения. Ключевые слова: когнитивные вызванные потенциалы, болезнь Паркинсона, Р300.Cognitive deterioration is not an initial symptom of Parkinson's disease but occurs over the course of the disease with the incidence of dementia. The P300 component of event-related potentials appears to be sensitive to cognitive impairment, and has been used to examine cognitive functions in Parkinson's disease. Although many studies have shown that P300 latency and amplitude are correlated with cognitive functions, there is a sufficient amount of controversial results. The authors have reviewed the results and suggested that the method should be used only in the combination with clinical and neuropsychological examinations. Further studies are needed.

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Age and stage dependency of P300 latency alterations in non-demented Parkinson's disease patients without therapy

Cited by 35 publications

References 59 publications

Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients

Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Event-related potentials in Parkinson’s disease

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