Age and sex related self-reported symptoms in a general population across 30 years: Patterns of reporting and secular trend

Bardel, Annika; Wallander, Mari‐Ann; Wallman, Thorne; Rosengren, Annika; Johansson, Saga; Eriksson, Henry; Svärdsudd, Kurt

doi:10.1371/journal.pone.0211532

Cited by 31 publications

(30 citation statements)

References 12 publications

(26 reference statements)

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“…Previous studies have shown that women generally report a higher number of symptoms than men (3,5,46,47). A Norwegian population study (47) also found that women reported a higher number of symptoms than men, although the association between somatic symptoms and anxiety and depression was equally strong in men and women indicating that the difference in prevalence of these conditions between the sexes could not explain the difference in the reported number of somatic symptoms.…”

Section: Discussionmentioning

confidence: 92%

Symptoms in the general Norwegian adult population - prevalence and associated factors

Krogstad

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et al. 2020

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Background: Patients´ own perceptions and evaluations of symptoms, functioning and other health-related factors, i.e. Patient Reported Outcomes (PROs), are important elements for providing good patient care. Symptoms are subjective and best elicited by the patient orally or by using PRO measures (PROMs), be it on paper, or as electronic assessment tools. Reference values on frequently used PROMs facilitate the interpretation of scores for use in clinics and research settings, by comparing patient data with relevant samples from the general population. Study objectives were to (1) present reference values for the M.D. Anderson Symptom Inventory (MDASI) (2) examine the occurrence and intensity of symptoms assessed by the MDASI in a general Norwegian adult population sample, and (3) examine factors associated with higher symptom burden defined as the sum score of all symptoms, and factors associated with symptoms` interference on functions.Methods: In 2015, MDASI was sent by mail as part of a larger survey, to a representative sample of the general Norwegian adult population (N = 6165). Medical comorbidities were assessed by the Self-Administered Comorbidity Questionnaire. Depression was self-reported on the Patient Health Questionnaire 9 (PHQ-9). Linear multivariable regression analysis was used to examine for factors associated with MDASI sum score and factors associated with symptoms’ interference on functions. Results: The response rate was 36%. More women (54%) than men (46%) responded. Mean age was 55 years (SD 14). The most frequent symptoms were fatigue (59.7%), drowsiness (56.2%) and pain (56.1%). Fatigue, pain and disturbed sleep had the highest mean scores. The presence of one or more comorbidities, increasing PHQ-9 score and lower level of education were associated with higher MDASI sum score (p<0.001). The MDASI sum score and the PHQ-9 score were positively associated with all interference items (p<0.001) except for walking (p=0.22). Conclusion: This study provides the first Norwegian reference values for MDASI. The presence of one or more comorbidities, higher level of depressive symptoms and lower level of education were significantly associated with higher MDASI sum score. These covariates must be controlled for when using the reference values.

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Section: Discussionmentioning

confidence: 92%

Symptoms in the general Norwegian adult population - prevalence and associated factors

Krogstad

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Grotmol

et al. 2020

Preprint

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“…The authors emphasize that readers have to be cautious with the external validity of the current findings, as mostly women responded, whom are more likely to present themselves with symptoms than men [24]. Moreover, only COVID-19 patients from Facebook groups with persistent symptoms and who registered on www.coronalongplein.nl were included in the study.…”

Section: Discussionmentioning

confidence: 98%

Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?

et al. 2020

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BackgroundMany patients with COVID-19 do not require hospitalisation, let alone have undergone COVID-19 testing. There is anecdotal evidence that patients with “mild” COVID-19 may complain about persistent symptoms, even weeks after the infection. This suggests that symptoms during the infection may not resolve spontaneously. The objective of this study was to assess whether multiple relevant symptoms recover following the onset of symptoms in hospitalised and non-hospitalised patients with COVID-19.Methods2113 members of two Facebook groups for coronavirus patients with persistent complaints in The Netherlands and Belgium, and from a panel of people who registered at a website of the Lung Foundation Netherlands, were assessed for demographics, pre-existing comorbidities, health status, date of symptoms onset, COVID-19 diagnosis, healthcare utilisation, and the presence of 29 symptoms at the time of the onset of symptoms (retrospectively) and at follow-up (79±17 days after symptoms onset).Results112 hospitalised patients and 2001 non-hospitalised patients (confirmed COVID-19, n=345; symptom-based COVID-19, n=882; and suspected COVID-19, n=774) were analysed. The median number of symptoms during the infection reduced significantly over time (14 (11–17) versus6 (4–9), p<0.001). Fatigue and dyspnoea were the most prevalent symptoms during the infection and at follow-up (fatigue: 95% versus 87%; dyspnoea: 90% versus 71%).ConclusionIn previously hospitalised and non-hospitalised patients with confirmed or suspected COVID-19, multiple symptoms are present about 3 months after symptoms onset. This suggests the presence of a “post-COVID-19 syndrome” and highlights the unmet healthcare needs in a subgroup of patients with “mild” or “severe” COVID-19.

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“…Previous studies have shown that women generally report a higher number of symptoms than men (3,5,42,43). A Norwegian population study (43) also found that women reported a higher number of symptoms than men, although the association between somatic symptoms and anxiety and depression was equally strong in men and women indicating that the difference in prevalence of these conditions between the sexes could not explain the difference in the reported number of somatic symptoms.…”

Section: The Health Study Of Nord-trøndelag County (Hunt 3)mentioning

confidence: 92%

Symptoms in the general Norwegian adult population - prevalence and associated factors

Krogstad

Loge

Grotmol

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Patients´ own perceptions and evaluations of symptoms, functioning and other health-related factors, i.e. Patient Reported Outcomes (PROs), are important elements for providing good patient care. Symptoms are subjective and best elicited by the patient orally or by using PRO measures (PROMs). Reference values on frequently used PROMs facilitate the interpretation of PROMs scores both in clinics and research settings, by comparing patient data with relevant samples from the general population. Objectives Study objectives were to (1) present reference values for the M.D. Anderson Symptom inventory (MDASI) (2) examine the occurrence and intensity of symptoms assessed by the MDASI in a general Norwegian adult population sample, and (3) examine factors associated with higher symptom burden defined as the sum score of all symptoms, and factors associated with symptoms` interference on functions Methods In 2015, MDASI was sent by mail to a representative sample of the general Norwegian adult population (N = 6165). Medical comorbidities were assessed by the Self-Administered Comorbidity Questionnaire. Depression was self-reported on the Patient Health Questionnaire 9 (PHQ-9). Linear multivariable regression analysis was used to examine for factors associated with MDASI sum score and factors associated with symptoms’ interference on functions. Results The response rate was 36%. More females (54%) than males (46%) responded. Mean age was 55 years (SD 14). The most frequent symptoms were fatigue (59.7%), drowsiness (56.2%) and pain (56.1%). Fatigue, pain and disturbed sleep had the highest mean scores. The presence of one or more comorbidities, increasing PHQ-9 score and lower level of education were associated with higher MDASI sum score (p<0.001). The MDASI sum score and the PHQ-9 score were positively associated with all interference items (p<0.001) except for walking (p=0.22). Conclusion This study provides the first Norwegian reference values for the MDASI. The presence of one or more comorbidities, higher level of depressive symptoms and lower level of education were significantly associated with higher MDASI sum score. These covariates must be controlled for when using the reference values.

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Age and sex related self-reported symptoms in a general population across 30 years: Patterns of reporting and secular trend

Cited by 31 publications

References 12 publications

Symptoms in the general Norwegian adult population - prevalence and associated factors

Symptoms in the general Norwegian adult population - prevalence and associated factors

Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?

Symptoms in the general Norwegian adult population - prevalence and associated factors

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