Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin

Ponthieux, Anne; Herbeth, Bernard; Droesch, Suzanne; Lambert, Daniel; Visvikis, Sophie

doi:10.1373/49.9.1544

Cited by 23 publications

(15 citation statements)

References 16 publications

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“…It has been reported that DHA content of granulocytes is negatively associated with intercellular CAM-1 (ICAM-1) levels, while granulocyte content of EPA is not correlated with ICAM-1 or vascular CAM-1 levels [38]. Furthermore, P-selectin has been reported to be inversely associated with estrogen levels [39]; indeed, females are reported to have significantly lower levels of CAM expression [40,41] and higher levels of DHA [42].…”

Section: Discussionmentioning

confidence: 99%

Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

Phang

Lincz

Seldon

et al. 2012

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

Phang

Lincz

Seldon

et al. 2012

The Journal of Nutritional Biochemistry

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“…Important age-related quantitative changes have been reported in haemostatic factors [22], [23] platelet count [24], [25] and reactivity [26], [27] among children, including decreasing soluble P-selectin in serum with age [28]. These age-related changes in haemostasis have important implications in the clinical management of children [23].…”

Section: Introductionmentioning

confidence: 99%

First Report of Elevated Monocyte-Platelet Aggregates in Healthy Children

et al. 2013

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Platelets are subcellular fragments which circulate in blood and have well established roles in thrombosis and haemostasis in adults. Upon activation, platelets undergo granule exocytosis and express P-Selectin on the cell membrane which binds a ligand on monocytes, leading to monocyte-platelet aggregation. Elevated circulating monocyte-platelet aggregates in adults are linked to atherothrombosis, but have not been investigated in children where thrombosis is less common. This study aimed to measure monocyte-platelet aggregate formation in children using whole blood flow cytometry. Monocyte-platelet aggregates as well as activation and granule exocytosis of platelets were measured in healthy adults (n = 15, median age 28 years) and healthy children (n = 28, median age 7 years). Monocyte-platelet aggregates in healthy children were elevated compared to healthy adults (37.8±4.4% vs 15.5±1.9% respectively, p<0.01). However, this was not accompanied by any difference in platelet activation (PAC-1 binding 6.8±1.5% vs 6.3±2.0% respectively, p = ns) or granule exocytosis (P-selectin expression 4.4±0.5% vs 3.1±0.5% respectively, p = ns). Despite comparable numbers of platelets bound per monocyte (GPIb MFI 117.3±13.7 vs 130.9±28.6 respectively, p = ns), surface P-selectin expression per platelet-bound monocyte was lower in children compared to adults. We therefore provide the first data of elevated monocyte-platelet aggregates in healthy children.

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“…15 sE-selectin actually exerts a proinflammatory effects upon neutrophil function at site of inflammation, thereby exacerbating the disease process. 16 The circulating concentrations of sE-selectin may serve as a potential biomarker of endothelial dysfunction and may be useful for monitoring the process of inflammation of the vessel wall. 17 Biomarker is a substance that is measured objectively and evaluated as an indicator of normal biologic processes, pathogenic processes or pharmacologic responses to a therapeutic intervention.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Determination of Serum Soluble E-Selectin in Periodontal Health and Disease

Nagarajan¹,

Krishnamurthi²,

Ponnusamy³

et al. 2018

JIMD

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Abstract:Back ground: Inflammatory periodontal disease has been associated with an increased risk of cardiovascular events. Emerging evidence shows an association of periodontal disease with systemic inflammation and endothelial dysfunction, while the underlying mechanism remains unclear. Circulating cell adhesion molecule sE-selectin has been suggested as a potential candidate marker of endothelial dysfunction, which contributes to the pathogenesis of cardiovascular diseases. Aim: To determine the serum sE-selectin level in generalised severe chronic periodontitis and periodontally healthy subjects. Materials and methods: Eighty subjects in the age group of 35-55 years were included in the study. Forty subjects with generalised severe chronic periodontitis as study group and 40 healthy subjects without periodontal disease as control group were selected. The blood samples were collected and the serum was analysed for sE-selectin level by ELISA. Results: sE-selectin expression was found in serum of both the groups. Mean serum sE-selectin levels were 37.05ng/mL in the study group and 30.78ng/mL in control group. Statistically significant increase was not found in serum sE-selectin levels between the groups. Conclusion: sE-selectin is expressed in serum of both the study and control groups with a wide range of distribution. No significant association was observed between sE-selectin level and periodontal inflammation. Therefore, circulating sE-selectin may not be used as a reliable biomarker of endothelial function measure in periodontal disease.

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Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin

Cited by 23 publications

References 16 publications

Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

First Report of Elevated Monocyte-Platelet Aggregates in Healthy Children

Quantitative Determination of Serum Soluble E-Selectin in Periodontal Health and Disease

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