Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice

Roger-Sánchez, C.; Aguilar, M.A.; Rodrı́guez-Arias, Marta; Aragón, Carlos M.G.; Miñarro, José

doi:10.1016/j.ntt.2011.07.011

Cited by 40 publications

(31 citation statements)

References 87 publications

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“…This finding is consistent with the observation that adolescent female mice display CPP produced by ethanol in the early and late phases of adolescence, whereas males only display CPP produced by ethanol in the early phase of adolescence (Roger-Sanchez et al 2012). Our findings are also consistent with studies showing that adolescent females consume more ethanol compared to adolescent male rats (Truxell et al 2007) and mice (Tambour et al 2008).…”

Section: Discussionsupporting

confidence: 92%

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Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent

Torres

Walker

Beas

et al. 2013

Alcohol Clin Exp Res

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Background Ethanol abuse is a major health and economic concern, particularly for females who appear to be more sensitive to the rewarding effects of ethanol. This study compared sex differences to the rewarding and aversive effects of ethanol using place-conditioning procedures in rats. Methods Separate groups of adult (male, female, ovariectomized [OVX] female) and adolescent (male and female) rats received ethanol (0, 0.5, 1.0, 2.0 or 2.5 g/kg; ip) and were confined to their initially non-preferred side of our conditioning apparatus for 30 minutes. On alternate days, they received saline and were confined to the other side. Following 5 drug pairings, the rats were re-tested for preference behavior. Separate cohorts of the same groups of rats were injected with a similar dose range of ethanol and blood ethanol levels (BELs) were compared 30 minutes later. Results Ethanol produced rewarding or aversive effects in a dose-dependent manner. An intermediate dose of ethanol (1.0 g/kg) produced rewarding effects in adult female but not male or OVX female rats, suggesting that ovarian hormones facilitate the rewarding effects of ethanol. Similarly, this intermediate dose of ethanol produced rewarding effects in adolescent female but not male rats. The highest dose of ethanol (2.5 g/kg) produced aversive effects that were similar across all adult groups. However, the aversive effects of ethanol were lower in adolescents than adults, suggesting that adolescents are less sensitive to the aversive effects of ethanol. The aversive effects of ethanol did not vary across the estrous cycle in intact adult females. There were also no group differences in BELs, suggesting that our results are not related to ethanol metabolism. Conclusion Our results in rats suggest that human females may be more vulnerable to ethanol abuse due to enhanced rewarding effects of this drug that are mediated by the presence of ovarian hormones.

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Section: Discussionsupporting

confidence: 92%

“…For example, ethanol-induced CPP was observed in female mice that were tested during the early and late phases of adolescence, whereas males only displayed CPP during the early phase of adolescence (Roger-Sanchez et al 2012). Adolescent female mice also consume more ethanol compared to their male counterparts (Tambour et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent

Torres

Walker

Beas

et al. 2013

Alcohol Clin Exp Res

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“…The final limitation of our study is the fact that only male mice were used. While there are several reports suggesting sex × age interactions in alcohol-related endpoints in C57BL/6 mice (Gallego et al, 2015, Melon et al, 2013, Roger-Sanchez et al, 2012, Strong et al, 2010), there is no such literature on sex differences and developmental changes in murine circadian timing. This represents an important future direction of inquiry for both chronobiology and alcohol research.…”

Section: Discussionmentioning

confidence: 99%

Differential Sensitivity to Ethanol‐Induced Circadian Rhythm Disruption in Adolescent and Adult Mice

Ruby

Palmer

Zhang

et al. 2016

Alcoholism Clin & Exp Res

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Background Growing evidence supports a central role for the circadian system in alcohol use disorders, but few studies have examined this relationship during adolescence. In mammals, circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), a biological clock whose timing is synchronized (reset) to the environment primarily by light (photic) input. Alcohol (ethanol) disrupts circadian timing in part by attenuating photic phase-resetting responses in adult rodents. However, circadian rhythms change throughout life and it is not yet known whether ethanol has similar effects on circadian regulation during adolescence. Methods General circadian locomotor activity was monitored in male C57BL6/J mice beginning in adolescence (P27) or adulthood (P61) in a 12 h light, 12 h dark photocycle for ~2 weeks to establish baseline circadian activity measures. On the day of the experiment, mice received an acute injection of ethanol (1.5 g/kg, i.p.) or equal volume saline 15 min prior to a 30-min light pulse at Zeitgeber Time 14 (2 h into the dark phase), then were released into constant darkness (DD) for ~2 weeks to assess phase-resetting responses. Control mice of each age group received injections but no light pulse prior to DD. Results While adults showed the expected decrease in photic phase-delays induced by acute ethanol, this effect was absent in adolescent mice. Adolescents also showed baseline differences in circadian rhythmicity compared to adults, including advanced photocycle entrainment, larger photic phase-delays, a shorter free-running (endogenous) circadian period, and greater circadian rhythm amplitude. Conclusions Collectively, our results indicate that adolescent mice are less sensitive to the effect of ethanol on circadian photic phase-resetting and that their daily activity rhythms are markedly different than those of adults.

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“…(Barcelona, Spain), was dissolved to 20% (v/v) in Sal and administered at a dose of 1.25 g/kg. This dose of EtOH was based on previously published reports, showing that it is able to induce the same blood concentration of approximately 90–130 mg/dl 5–30 minutes after its administration, respectively, in both adolescent and adult OF1 mice [22]. These blood EtOH levels correspond to 33–48 g of ethanol in humans, which represents three to five alcoholic drinks, as occurs in a binge-drinking episode [2, 23].…”

Section: Methodsmentioning

confidence: 99%

Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

et al. 2017

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BackgroundEthanol (EtOH) binge drinking is an increasingly common behavior among teenagers that induces long-lasting neurobehavioral alterations in adulthood. An early history of EtOH abuse during adolescence is highly correlated with cocaine addiction in adulthood. Abstinence of cocaine abuse can cause psychiatric symptoms, such as anxiety, psychosis, depression, and cognitive impairments. This study assessed the consequences of adolescent exposure to EtOH on the behavioral alterations promoted by cocaine withdrawal in adulthood.MethodsWe pretreated juvenile (34–47 days old) or adult (68–81 days old) mice with EtOH (1.25 g/kg) following a binge-drinking pattern. Then, after a three-week period without drug delivery, they were subjected to a chronic cocaine treatment in adulthood and tested under cocaine withdrawal by the ensuing paradigms: open field, elevated plus maze, prepulse inhibition, tail suspension test, and object recognition. Another set of mice were treated with the same EtOH binge-drinking procedure during adolescence and were tested immediately afterwards under the same behavioral paradigms.ResultsAdolescent EtOH pretreatment undermined the anxiogenic effects observed after cocaine abstinence, reduced prepulse inhibition, and increased immobility scores in the tail suspension test following cocaine withdrawal. Moreover, the memory deficits evoked by these substances when given separately were enhanced in cocaine-withdrawn mice exposed to EtOH during adolescence. EtOH binge drinking during adolescence also induced anxiety, depressive symptoms, and memory impairments when measured immediately afterwards. In contrast, neither EtOH nor cocaine alone or in combination altered any of these behaviors when given in adulthood.ConclusionsEtOH binge drinking induces short- and long-term behavioral alterations and modulates cocaine withdrawal symptoms when given in adolescent mice.

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Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice

Cited by 40 publications

References 87 publications

Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent

Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent

Differential Sensitivity to Ethanol‐Induced Circadian Rhythm Disruption in Adolescent and Adult Mice

Adolescent but not adult ethanol binge drinking modulates cocaine withdrawal symptoms in mice

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