Age and sex differences for malignant melanoma in the pediatric population—childhood versus adolescence: analysis of current nationwide data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program

Kelm, Ryan C.; Ali, Yasmeen; Orrell, Kelsey A.; Rangel, Stephanie M.; Kruse, Lacey; Wagner, Annette; Gerami, Pedram; West, Dennis P.; Nardone, Beatrice

doi:10.1016/j.jaad.2020.10.050

Cited by 8 publications

(6 citation statements)

References 4 publications

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“…In Canada [ 204 ], Italy [ 205 ], and England [ 206 ] there is evidence that the incidence of melanoma is stabilising in younger age groups. The incidence in children aged 10–19 in the United States also decreased from 2000 to 2015 [ 207 ]. In Eastern Europe, studies from Lithuania (1991–2015) and Ukraine (2002–2013) reported increased incidence of melanoma in all age groups [ 208 , 209 ], but there is evidence of a recent decline in incidence in Hungary [ 210 ].…”

Section: Human Healthmentioning

confidence: 99%

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021

Barnes

Robson

Neale

et al. 2022

Photochem Photobiol Sci

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The Environmental Effects Assessment Panel of the Montreal Protocol under the United Nations Environment Programme evaluates effects on the environment and human health that arise from changes in the stratospheric ozone layer and concomitant variations in ultraviolet (UV) radiation at the Earth’s surface. The current update is based on scientific advances that have accumulated since our last assessment (Photochem and Photobiol Sci 20(1):1–67, 2021). We also discuss how climate change affects stratospheric ozone depletion and ultraviolet radiation, and how stratospheric ozone depletion affects climate change. The resulting interlinking effects of stratospheric ozone depletion, UV radiation, and climate change are assessed in terms of air quality, carbon sinks, ecosystems, human health, and natural and synthetic materials. We further highlight potential impacts on the biosphere from extreme climate events that are occurring with increasing frequency as a consequence of climate change. These and other interactive effects are examined with respect to the benefits that the Montreal Protocol and its Amendments are providing to life on Earth by controlling the production of various substances that contribute to both stratospheric ozone depletion and climate change.

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Section: Human Healthmentioning

confidence: 99%

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021

Barnes

Robson

Neale

et al. 2022

Photochem Photobiol Sci

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“…Populations with lower socioeconomic status or from minority groups were more likely to have thicker melanomas over the time period examined, likely due to poorer access to screening and early detection activities. While the incidence of melanoma in children is very low, between 2000 and 2015 in the United States declines in incidence were reported for children aged 10–19 years, while incidence in younger children remained stable [ 74 ].…”

Section: Harms Of Exposure To Uv Radiationmentioning

confidence: 99%

The effects of exposure to solar radiation on human health

Neale

Lucas

Byrne

et al. 2023

Photochem Photobiol Sci

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This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts. Of particular note, there is new information about the way in which exposure to UV radiation modulates the immune system, causing both harms and benefits for health. The burden of skin cancer remains high, with many lives lost to melanoma and many more people treated for keratinocyte cancer, but it has been estimated that the Montreal Protocol will prevent 11 million cases of melanoma and 432 million cases of keratinocyte cancer that would otherwise have occurred in the United States in people born between 1890 and 2100. While the incidence of skin cancer continues to rise, rates have stabilised in younger populations in some countries. Mortality has also plateaued, partly due to the use of systemic therapies for advanced disease. However, these therapies are very expensive, contributing to the extremely high economic burden of skin cancer, and emphasising the importance and comparative cost-effectiveness of prevention. Photodermatoses, inflammatory skin conditions induced by exposure to UV radiation, can have a marked detrimental impact on the quality of life of sufferers. More information is emerging about their potential link with commonly used drugs, particularly anti-hypertensives. The eyes are also harmed by over-exposure to UV radiation. The incidence of cataract and pterygium is continuing to rise, and there is now evidence of a link between intraocular melanoma and sun exposure. It has been estimated that the Montreal Protocol will prevent 63 million cases of cataract that would otherwise have occurred in the United States in people born between 1890 and 2100. Despite the clearly established harms, exposure to UV radiation also has benefits for human health. While the best recognised benefit is production of vitamin D, beneficial effects mediated by factors other than vitamin D are emerging. For both sun exposure and vitamin D, there is increasingly convincing evidence of a positive role in diseases related to immune function, including both autoimmune diseases and infection. With its influence on the intensity of UV radiation and global warming, the Montreal Protocol has, and will have, both direct and indirect effects on human health, potentially changing the balance of the risks and benefits of spending time outdoors. Graphical abstract

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“…After the accident, cancer is prioritized as the second reason for mortality among children aged 1 to 14. Since cancer growing in childhood has no speci c symptoms, it is diagnosed a long time after its creation [5][6][7][8]. The types of cancer are various in childhood and are entirely different from adults, while its rate is less than the number of adults by 10% [9].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Family-Centered Empowerment Model Based on Mucosal Management on the Quality of Life of Children with Cancer Undergoing Chemotherapy

Farsani¹,

Moghaddasi²

2023

Preprint

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Introduction Inflammation of the oral mucosa is one of the conventional side effects of chemotherapy, affecting the patient's acceptance and treatment process. Hence, the knowledge regarding the complication and the methods to prevent them helps improve the course of treatment, prevent frequent hospitalizations, and survive these patients. The current study aims to implement the family-centered empowerment model based on mucositis management on the quality of life of children with cancer undergoing chemotherapy. Method A randomized study is presented in this paper that is conducted on 60 parents of children with cancer undergoing chemotherapy. These children were referred to Shahrekord Kashani Hospital in 2019–2020. The authors received informed consent from the parents who also participated in the tests. The parents were selected using the available sampling method and divided into two intervention and control groups through random allocation. In the intervention group, based on the empowerment model of the Al-Hani family, the intervention's content was consolidated in person and virtual space. Whereas in the control group, routine training was provided by nurses. To collect data from the demographic information questionnaire, the children's quality of life questionnaire was considered based on the parents' point of view. Ped QL Cancer Modules were used, which were electronically provided to the control and intervention groups in the three stages before, immediately after, and three months after the end of the intervention. Besides, who oral mucositis grading scale was employed for measuring mucositis. The collected data were analyzed using descriptive, analytical, and statistical tests (frequency and percentage, mean and standard deviation, and Fisher's exact test) and using SPSS23 software. Findings The obtained results revealed that the children's quality of life in the two groups immediately and three months after the intervention had a significant difference (p < 0.001). Accordingly, the quality of life of the children in the intervention group (35.12 ± 66.30) represented a significant rise (p < 0.001) compared to the control group (-4.6 ± 7.6). Conclusion The results indicated that the empowerment program could help parents discover the reality and increase awareness, ability, skill, and critical thinking. Therefore, the obtained results can prevent complicating the inflammation of the oral mucosa in children undergoing chemotherapy. Reducing hospitalization due to chemotherapy complications will improve children's quality of life.

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Age and sex differences for malignant melanoma in the pediatric population—childhood versus adolescence: analysis of current nationwide data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program

Cited by 8 publications

References 4 publications

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2021

The effects of exposure to solar radiation on human health

The Effect of Family-Centered Empowerment Model Based on Mucosal Management on the Quality of Life of Children with Cancer Undergoing Chemotherapy

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