Age and obesity alter the relationship between femoral articular cartilage thickness and ambulatory loads in individuals without osteoarthritis

Blazek, Katerina; Favre, Julien; Asay, Jessica L.; Erhart‐Hledik, Jennifer C.; Andriacchi, Thomas P.

doi:10.1002/jor.22530

Cited by 65 publications

(60 citation statements)

References 47 publications

(60 reference statements)

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“…In agreement with previous research, this study found a significant correlation between mean and peak thickness of the weight-bearing region of both condyles and overall cartilage loading (S2 and S3 Figs)[7–9]. Due to the specific methodology used i.e.…”

Section: Discussionsupporting

confidence: 90%

“…Previous research demonstrated a relation between KAM and medial condyle thickness, whereas we are first to describe the relation between cartilage thickness and cartilage loading of both condyles[7–9]. More specific, an additional relation between lateral condyle loading and lateral condyle thickness was found.…”

Section: Discussionmentioning

confidence: 77%

“…Increased cartilage volume was found with increased physical activity level in healthy children and with increased muscle cross-sectional area in healthy adults[5,6]. A positive correlation between knee external adduction moment (KAM) and medial cartilage thickness or medial to lateral thickness ratio in a cohort of healthy adults was reported [7–9]. Knee and shoulder cartilage thinning was observed in paraplegic patients due to unloading[10,11].…”

Section: Introductionmentioning

confidence: 99%

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Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

Rossom

Zevenbergen

et al. 2017

PLoS ONE

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Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired. Experimental gait data was processed using musculoskeletal modeling to calculate the contact forces, impulses and pressure distribution in the tibiofemoral joint. Correlates to local cartilage thickness and mean T1ρ and T2 relaxation times of the weight-bearing area of the femoral condyles were examined. Local thickness was significantly correlated with local pressure: medial thickness was correlated with medial condyle contact pressure and contact force, and lateral condyle thickness was correlated with lateral condyle contact pressure and contact force during stance. Furthermore, average T1ρ and T2 relaxation time correlated significantly with the peak contact forces and impulses. Increased T1ρ relaxation time correlated with increased shear loading, decreased T1ρ and T2 relaxation time correlated with increased compressive forces and pressures. Thicker cartilage was correlated with higher condylar loading during walking, suggesting that cartilage thickness is increased in those areas experiencing higher loading during a cyclic activity such as gait. Furthermore, the proteoglycan and collagen concentration and orientation derived from T1ρ and T2 relaxation measures were related to loading.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

Rossom

Zevenbergen

et al. 2017

PLoS ONE

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“…Therefore, a number of studies have sought to understand how cartilage is loaded during activities of daily living. For example, some studies have used skin markers and in-ground force plates to estimate loading distributions between the medial and lateral compartments of the tibiofemoral joint 7, 36 . Other studies have used biplanar radiographic images to measure joint kinematics and changes in joint space during activities such as walking and running 18, 40 .…”

Section: Introductionmentioning

confidence: 99%

In Vivo Measurement of Localized Tibiofemoral Cartilage Strains in Response to Dynamic Activity

et al. 2014

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Introduction Altered local mechanical loading may disrupt normal cartilage homeostasis and play a role in the progression of osteoarthritis. Currently, there is limited data quantifying local cartilage strains in response to dynamic activity in normal or injured knees. Purpose The purpose of this study was to directly measure local tibiofemoral cartilage strains in response to a dynamic hopping activity in normal healthy knees. We hypothesize that local regions of cartilage will exhibit significant compressive strains in response to hopping, while overall compartmental averages may not. Study Design Controlled laboratory study. Methods Both knees of eight healthy subjects were MR imaged before and immediately after a dynamic hopping activity. Images were segmented and then used to create 3D surface models of bone and cartilage. These pre- and post-activity models were then registered using an iterative closest point technique to enable site-specific measurements of cartilage strain (defined as the normalized change in cartilage thickness before and after activity) on the femur and tibia. Results Significant strains were observed in both the medial and lateral tibial cartilage, with each compartment averaging a decrease of 5%. However, these strains varied with location within each compartment, reaching a maximum compressive strain of 8% on the medial plateau and 7% on the lateral plateau. No significant averaged compartmental strains were observed in the medial or lateral femoral cartilage. However, local regions of the medial and lateral femoral cartilage experienced significant compressive strains, reaching maximums of 6% and 3% respectively. Conclusion Local regions of both the femur and tibia experienced significant cartilage strains as a result of dynamic activity. An understanding of changes in cartilage strain distributions may help to elucidate the biomechanical factors contributing to cartilage degeneration after joint injury.

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“…Indivíduos obesos apresentam maior frequência de lesões condrais dos compartimentos medial e FP do joelho visualizadas nas artroscopias para tratamento de lesões do menisco (124) . Os resultados funcionais de artroscopias de joelho realizadas em mulheres obesas são inferiores, quando comparados aos de não-obesas (86) e existe uma associação entre IMC ≥ 30 kg/m 2 e uma maior frequência de lesões de menisco com indicação cirúrgica, em homens e mulheres (125) , que pode ser explicada pela sobrecarga mecânica associada `a fraqueza muscular decorrente do despreparo físico destes pacientes (126,127) . (135) .…”

Section: Estatísticaunclassified

Incidência e fatores de risco para fratura vertebral por osteoporose em idosos brasileiros da comunidade: um estudo prospectivo de base populacional. São Paulo Ageing e Health (SPAH) Study

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À Claudia, minha esposa, pelo amor, apoio e companheirismo e ao Lucas, nossa melhor obra, alegria das nossas vidas. AGRADECIMENTOSAo meu orientador e amigo, Prof. Dr. José Ricardo Pécora, pelo apoio durante todas as fases deste projeto de pesquisa e pela lucidez e gentileza no trato com as pessoas, qualidades que o distinguem.Ao Prof. Dr. Gilberto Luis Camanho, minha admiração e imensa gratidão pelos ensinamentos, pela amizade de tantos anos e por todas as oportunidades profissionais que me ofereceu na vida.Aos colegas ortopedistas Dr. Alexandre Leme Godoy, Dr. Marcos Hideyo Sakaki e Dr. Marco Kawamura Demange, pelas valiosas sugestões que deram na etapa de qualificação.Ao Henry Dan Kyomoto, pelo árduo trabalho estatístico que realizou com precisão e competência.A todos os pacientes que estiveram sob os meus cuidados e que gentilmente concordaram em ceder seus dados para esta pesquisa. Sem eles, nada disso teria sido possível e nada disso faria qualquer sentido. Entretanto, a noção de que os meniscos desempenham importantes funções biomecânicas na transmissão de cargas e absorção de impactos nos joelhos e de que a meniscectomia não é um procedimento isento de riscos e complicações data da metade do século passado (2) e embasa um preceito básico das meniscectomias, que consiste em se remover a menor fração possível do menisco lesionado.Na metade do século XX, a ressecção mínima do menisco começou a ser defendida no meio científico, a fim de prevenir a degeneração articular do joelho observada tardiamente nos pacientes submetidos à meniscectomia total (3) . Avanços tecnológicos a partir da década de 70 permitiram que a meniscectomia por via artroscópica substituísse a meniscectomia total aberta, com inúmeras vantagens: menor tempo de hospitalização, menor morbidade cirúrgica, menores custos e recuperação mais rápida dos pacientes (3) . Por estes motivos, consagrou-se e popularizou-se como técnica de escolha no tratamento das lesões dos meniscos não passíveis de sutura (4,5) , sendo atualmente o procedimento cirúrgico ortopédico mais frequentemente realizado no mundo (6,7) .O suprimento sanguíneo dos meniscos provém da periferia, irrigando apenas sua porção periférica, o que confere baixa capacidade de cicatrização e regeneração da sua porção interna (8) . Indivíduos com mais de 50 anos de idade possuem meniscos com menor vascularização e celularidade e, consequentemente, menor capacidade de regeneração do que os mais jovens (9) .As lesões dos meniscos podem ser divididas, quanto à natureza, em traumáticas e degenerativas. As lesões degenerativas decorrem de sobrecarga cumulativa ao longo dos anos e, portanto, sua incidência 3 aumenta com a idade (10) . Tais lesões são encontradas nos exames de ressonância magnética (RM) de cerca de 35% da população com mais de 50anos, sendo dois terços delas assintomáticas e associadas a outras manifestações degenerativas do joelho (11) . Por este motivo, as lesões não traumáticas dos meniscos nesta faixa etária representam um desafio para o ortopedista, pela dificuldade em se di...

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Age and obesity alter the relationship between femoral articular cartilage thickness and ambulatory loads in individuals without osteoarthritis

Cited by 65 publications

References 47 publications

Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

Knee Cartilage Thickness, T1ρ and T2 Relaxation Time Are Related to Articular Cartilage Loading in Healthy Adults

In Vivo Measurement of Localized Tibiofemoral Cartilage Strains in Response to Dynamic Activity

Incidência e fatores de risco para fratura vertebral por osteoporose em idosos brasileiros da comunidade: um estudo prospectivo de base populacional. São Paulo Ageing e Health (SPAH) Study

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