Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats

Korach-André, Marion; Gounarides, John S.; Deacon, Richard; Beil, Michael E.; Sun, Dongming; Gao, Jiaping; Laurent, Didier

doi:10.1016/j.metabol.2004.11.006

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…This correlation between visceral adiposity and IMCL was also found in previous studies in lean and obese adolescents (32), and in rat models of insulin resistance (37). Central fat accumulation, rather than excess peripheral fat, is well accepted as a predisposing factor for insulin resistance (18,36).…”

Section: Discussionsupporting

confidence: 83%

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Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Youngren

Hyun

et al. 2008

Magnetic Resonance Imaging

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Objectives-To develop protocols that measure abdominal fat by MRI and calf muscle lipids by MR spectroscopy (MRS) at 3 Tesla, and to examine the correlation between these parameters and insulin sensitivity.Materials and Methods-Ten non-diabetic subjects, five insulin-sensitive (IS) and five insulinresistant (IR), were scanned at 3T. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were segmented semi-automatically from abdominal imaging. Intramyocellular lipids (IMCL) in calf muscles were quantified from single voxel MRS in both soleus and tibialis anterior muscles, and from MR spectroscopic imaging (MRSI), respectively.Results-The average coefficient of variation (CV) of VAT/(VAT+SAT) was 5.2%. The interoperator CV was 1.1% and 5.3% for SAT and VAT estimates, respectively. The CV of IMCL was 13.7% in soleus, 11.9% in tibialis anterior, and 2.9% with MRSI. IMCL based on MRSI (3.8% ± 1.2%) was significantly inversely correlated with glucose disposal rate measured by a hyperinsulinemic euglycemic clamp. VAT volume correlated significantly with IMCL. IMCL based on MRSI for IR subjects was significantly greater than that for IS subjects (4.5% ± 0.9% vs. 2.8% ± 0.5%, P = 0.02). Conclusion-MRI/MRStechniques provide robust, non-invasive measurement for abdominal fat and muscle IMCL that are correlated with insulin action in humans.

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Section: Discussionsupporting

confidence: 83%

“…Accumulation of visceral rather than subcutaneous fat is thought to constitute the link between glucose intolerance and IMCL stores (32). However, a causal relationship between visceral fat and IMCL has not been established (37).…”

Section: Discussionmentioning

confidence: 99%

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Youngren

Hyun

et al. 2008

Magnetic Resonance Imaging

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“…Recently, myofiber-type composition of skeletal muscle has attracted great attention both in human health and animal production, owing to its close association with insulin sensitivity in mammals (Hickey et al, 1995;Korach-André et al, 2005) and its significance for lean-mass deposition and meat quality in meat-producing animals (Maltin et al, 2003), respectively. Adult skeletal muscle displays plasticity that allows the conversion of different fiber types in response to chronic change in contractile demands (Hood, 2001;Schiaffino and Reggiani, 2011).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional co-activator PGC-1α gene is associated with chicken skeletal muscle fiber types

JingTing¹,

Xu²,

Zhang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) is a candidate gene for meat quality traits because of its prominent role in muscle fiber type switching and determination. We investigated the effects of the PGC-1α gene on chicken skeletal muscle fiber type switching and on other meat quality traits. Single nucleotide polymorphisms were detected by PCR-SSCP and DNA sequencing, and then genotyping was performed by PCR-ligation detection reaction methods. Skeletal muscle fiber types, intramuscular fat content, shear forces, and water loss rate of the gastrocnemius lateralis muscle were measured in Qingyuan Partridge chickens and Recessive White chickens. Four SNPs, C171T in exon2, C384T in exon3, G646A in exon5, and A948G in exon8 were detected. Marker-trait association analysis indicated that G646A polymorphism was associated with skeletal myofiber type and that H1 (CCAA) was the most advantageous haplotype for skeletal myofiber type. We concluded that polymorphisms of the PGC-1α gene and their haplotypes are associated with chicken skeletal myofiber type traits.

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“…However, differential relationships of insulin sensitivity with differing muscles with varying oxidative activity have been reported in both animal and human studies. A study investigating the association of IMCL and insulin sensitivity in rats showed that the relationship differed depending on the specific muscle examined [34]. Specifically, they showed that an inverse association of glucose uptake was associated with tibialis anterior IMCL, but not soleus IMCL.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Insulin Sensitivity and Muscle Lipids may Differ with Muscle Group and Ethnicity

Lawrence

Gower²,

Garvey³

et al. 2010

TOOBESJ

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Intramyocellular lipid (IMCL) has been inversely associated with insulin sensitivity in some, but not all, studies. This study utilized fast, high-resolution, magnetic resonance spectroscopic imaging (MRSI) to: investigate relationships between muscle lipids (IMCL and extramyocellular lipid (EMCL)) and insulin sensitivity in muscles of varying oxidative capacity, explore ethnic differences in these relationships, and determine whether a eucaloric, low-fat dietary intervention would reduce IMCL and increase insulin sensitivity. Subjects were 30 healthy, African-American (AA; n=14) and European-American (EA; n=16) males, BMI 26.49 (±5.57) kg/m2, age 21.80 (±7.84) yrs. Soleus and tibialis anterior muscle lipids were quantified using MRSI. Insulin sensitivity was assessed via intravenous glucose tolerance test. A 2-week, eucaloric, low-fat diet intervention was conducted in a sub-group (n=12) subjects with assessments at baseline and post-intervention. Neither IMCL nor EMCL levels differed between ethnicities. In the total group, and within EA (but not AA), both tibialis anterior IMCL and EMCL were inversely associated with insulin sensitivity (P<0.05 for both); soleus muscle lipids were not associated with insulin sensitivity. Soleus, but not tibialis anterior, IMCL declined in both ethnic groups (average 25.3%; p<0.01) following dietary intervention; insulin sensitivity was unchanged. Results suggest that an association of muscle lipids with insulin sensitivity may be influenced by the oxidative capacity of the muscle group studied and may vary with ethnicity.

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Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats

Cited by 21 publications

References 30 publications

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T

Transcriptional co-activator PGC-1α gene is associated with chicken skeletal muscle fiber types

Relationship between Insulin Sensitivity and Muscle Lipids may Differ with Muscle Group and Ethnicity

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