Age and malignant melanoma: Comparison of variables in different age-groups

Rivers, Jason K.; Kelly, Mary; Kopf, Alfred W.; Welkovich, Bruce; Bart, Robert S.

doi:10.1016/s0190-9622(89)70243-7

Cited by 26 publications

(9 citation statements)

References 45 publications

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“…Figure 1 illustrates the increase in all age groups. The greatest increase, 131%, is seen in older men, in whom over the 11 year period the incidence increased from 7 8/100 000 to 18 0/100 000.…”

Section: Resultsmentioning

confidence: 94%

Melanoma in people aged 65 and over in Scotland, 1979-89.

McHenry

Hole

Mackie

1992

BMJ

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Section: Resultsmentioning

confidence: 94%

Melanoma in people aged 65 and over in Scotland, 1979-89.

McHenry

Hole

Mackie

1992

BMJ

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“…Elderly melanoma patients have been shown to present with tumors of advanced Breslow level 3, 9, 19, 20. Late diagnosis has been implicated as a cause for thicker melanoma with poor prognosis in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma in the Elderly: Different Regional Disease and Poorer Prognosis

Macdonald

Dueck²,

Gray³

et al. 2011

J. Cancer

104

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Purpose: Age is a poor prognostic factor in melanoma patients. Elderly melanoma patients have a different presentation and clinical course than younger patients. We evaluated the impact of age ≥70 years (yrs) on the diagnosis and natural history of melanoma.Methods: Retrospective review of 610 patients with malignant melanoma entered into a prospective sentinel lymph node (SLN) database, treated from June 1997 to June 2010. Disease characteristics and clinical outcomes were compared between patients ≥70 yrs vs. <70 yrs of age.Results: 237 patients (39%) were ≥70 yrs. Elderly patients had a higher proportion of head and neck melanomas (34% vs. 20%, p<0.001), and greater mean tumor thickness (2.4mm vs. 1.8mm, p<0.001). A greater proportion of T3 or T4 melanoma was seen in the elderly (p<0.001) as well as a greater mean number of mitotic figures: 3.6/mm2 vs. 2.7/mm2 (p=0.005). Despite greater mean thickness, the incidence of SLN metastases was less in the ≥70 yrs group with T3/T4 melanomas (18% vs. 33%, p=0.02). The elderly had a higher rate of local and in-transit recurrences, 14.5% vs. 3.4% at 5 yrs (p<0.001). 5 yr disease-specific mortality and overall mortality were worse for those ≥70 yrs: 16% vs. 8% (p=0.004), and 30% vs. 12% (p<0.001), respectively.Conclusions: Elderly (≥70 yrs) melanoma patients present with thicker melanomas and a higher mitotic rate but have fewer SLN metastases. Melanoma in the elderly is more common on the head and neck. Higher incidence of local/in-transit metastases is seen among the elderly. Five-year disease-specific mortality and overall mortality are both worse for these patients.

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“…The other main characteristic of the patients with thick melanoma that our data identify is that they are older. Other papers [17][18][19][20]22 also demonstrate that patients presenting with thick melanoma tend to be older. Another SMG paper 20 specifically looked at the presentation characteristics of patients aged > 65 years and showed that 37% present with thick melanoma compared with 18% in the < 65-year group.…”

Section: Discussionmentioning

confidence: 99%

Thick melanoma: the challenge persists

Murray

Stockton

Doherty

2005

British Journal of Dermatology

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Over a 20-year period there was little change in the absolute number of patients presenting with thick melanoma each year, though these form a diminishing proportion of the rising number of total melanomas. This thick melanoma group is characterized by an increasingly older age group and a changing type profile, nodular and SSM being the most common types. This work suggests that the resources currently directed at public and professional education on melanoma are having no effect on this group of patients and that alternative strategies may need to be considered.

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Age and malignant melanoma: Comparison of variables in different age-groups

Cited by 26 publications

References 45 publications

Melanoma in people aged 65 and over in Scotland, 1979-89.

Melanoma in people aged 65 and over in Scotland, 1979-89.

Malignant Melanoma in the Elderly: Different Regional Disease and Poorer Prognosis

Thick melanoma: the challenge persists

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