Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study

Cain, Peter; Ahl, Ragnhild; Hedström, Erik; Ugander, Martin; Allansdotter-Johnsson, Ase; Friberg, Peter; Arheden, Håkan

doi:10.1186/1471-2342-9-2

Cited by 174 publications

(146 citation statements)

References 25 publications

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“…These results correspond to a recently published cross-sectional study of sex-and age-specific normal values of the left ventricle from adolescence to late adulthood, in which the peak of the end-diastolic volume was found before 20 years of age, but the peak for the left ventricular muscle mass only after 30 years. 25 …”

Section: Study Findings: Sex and Age Effects On Ventricular Volumes Amentioning

confidence: 99%

Sex-Specific Pediatric Percentiles for Ventricular Size and Mass as Reference Values for Cardiac MRI

Sarikouch

Peters²,

Gutberlet³

et al. 2010

Circ: Cardiovascular Imaging

163

164

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Background-Cardiac MRI is important in the treatment of children with congenital heart disease, but sufficient normative data are lacking. For ventricular volumes and mass, we sought to deliver reference centiles and to investigate sex effects. Methods and Results-We included 114 healthy children and adolescents, uniformly distributed spanning an age range of 4 to 20 years, as required by the Lambda-Mu-Sigma method to achieve a percentile distribution, thus avoiding arbitrary age categories. Subjects underwent axial volumetry (1.5-T scanner) using standardized 2D steady-state free-precession and flow protocols. Percentiles were computed for age 8 to 20 years (99 subjects) because breath-holds were more consistent in this group. When indexed for body surface area or height, the centile curves of ventricular volumetric parameters showed allometric increase until adolescence, when a plateau was reached, with values comparable to published adult reference data. In contrast, ventricular mass centiles increased without plateau. There was a significant sex difference, with centiles reflecting larger values in boys than in girls (PϽ0.05) when ventricular volumes were indexed to body surface area or height but not when indexed to weight (exception: mass). There was excellent agreement of axial and short-axis volumetry and of volumetric and flow-derived stroke volumes. Conclusions-Percentiles for ventricular volumes and mass in healthy children have been established to serve as reference values in pediatric heart disease. Significant sex differences were noted when indexing volumes to body surface area or height. Unisex centiles related to weight may be considered for chamber volumes albeit not for mass. (Circ Cardiovasc Imaging. 2010;3:65-76.)

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Section: Study Findings: Sex and Age Effects On Ventricular Volumes Amentioning

confidence: 99%

Sex-Specific Pediatric Percentiles for Ventricular Size and Mass as Reference Values for Cardiac MRI

Sarikouch

Peters²,

Gutberlet³

et al. 2010

Circ: Cardiovascular Imaging

163

164

View full text Add to dashboard Cite

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“…LVM was divided by the body surface area to obtain the left ventricular mass index (LVMI, g/m 2 ). Measurement of left atrium (LA) and left ventricular (LV) volumes were computed from apical two chamber (A2C) views by Simpson›s method biplane method (25). LA and LV volume index was divided by the body surface area to obtain the LA and LV volume (mL//m 2 ).…”

Section: Biochemistry Examinationmentioning

confidence: 99%

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

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Background: Impaired subclinical ventricular function may contribute to the risk of cardiovascular disease in obesity. Aims: The aim of this study was to determine the influence of obesity on left ventricular (LV) longitudinal myocardial function in normotensive obese children using two-dimensional (2D) speckle tracking echocardiography (STE). Study Design: Case-control study. Methods: Sixty normotensive obese children aged 10-16 years (mean age, 13.9±2.3 years) were compared with 50 normal-weight controls. Obese participants had a body mass index (BMI)≥95 th percentile. Regional strain/strain rate (SR) values were compared with left ventricular (LV) parameters. The correlation was studied by linear regression analysis. Results: Obese subjects exhibited a significantly higher LV end-diastolic diameter, left atrium/aortic diameter ratio, and LV mass/index when compared to controls (p<0.001). Left ventricular ejection fraction and regional systolic myocardial velocities were similar in the obese and control groups. By 2D STE, regional strain of both the septal wall (average strain:

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“…Normalization to height,25 fat‐free mass (FFM),26 and weight27 have been proposed, but the method most commonly employed is normalization to BSA 28. The Mosteller index to BSA was chosen for this work since it is relatively simple, widely used, and validated on a wide range of subject sizes.…”

Section: Discussionmentioning

confidence: 99%

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Gandy

Lambert

Belch

et al. 2016

Magnetic Resonance Imaging

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PurposeTo scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.Materials and MethodsA population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady‐state free precession (SSFP) LV data in the short‐axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.ResultsMean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: –2.9 ± 1.3 ml/m2, females: –3.1 ± 0.8 ml/m2; ESVI males: –1.3 ± 0.7 ml/m2, females: –1.7 ± 0.5 ml/m2; SVI males: –1.7 ± 0.9 ml/m2, females: –1.4 ± 0.6 ml/m2; LVMI males: –1.6 ± 1.1 g/m2, females: –0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.ConclusionLV reference ranges are provided in this population‐based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population‐based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186–1196.

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Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study

Cited by 174 publications

References 25 publications

Sex-Specific Pediatric Percentiles for Ventricular Size and Mass as Reference Values for Cardiac MRI

Sex-Specific Pediatric Percentiles for Ventricular Size and Mass as Reference Values for Cardiac MRI

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

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