Age- and gender-specific epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture in Taiwan between 2009 and 2013

Wang, Chenyu; Fu, Shau-Huai; Yang, Rong‐Sen; Shen, Li‐Jiuan; Wu, Fe-Lin Lin; Hsiao, Fei‐Yuan

doi:10.1007/s11657-017-0385-5

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…Data on incidence rate of hip fracture was obtained from 9 Asian Federation of Osteoporosis Societies (AFOS) members, including China [ 14 , 15 ], Hong Kong [ 16 ], India [ 17 ], Japan [ 18 , 19 ], Korea [ 20 ], Malaysia [ 21 ], Singapore [ 21 ], Taiwan [ 22 , 23 ], and Thailand [ 24 ] ( Table 1 ). For Taiwan, we noted that a large difference in the incidence of hip fracture were estimated by two studies, due to Chie et al.…”

Section: Methodsmentioning

confidence: 99%

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An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study

Cheung

Ang

Chadha

et al. 2018

Osteoporosis and Sarcopenia

257

182

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ObjectivesHip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur in Asia. To date, only a few studies provided the updated projection, and none of them focused on the hip fracture projection in Asia. Thus, it is essential to provide the most up to date prediction of hip fracture in Asia, and to evaluate the total direct medical cost of hip fracture in Asia.MethodsWe provide the updated projection of hip fracture in 9 Asian Federation of Osteoporosis Societies members using the most updated incidence rate and projected population size.ResultsWe show that the number of hip fracture will increase from 1,124,060 in 2018 to 2,563,488 in 2050, a 2.28-fold increase. This increase is mainly due to the changes on the population demographics, especially in China and India, which have the largest population size. The direct cost of hip fracture will increase from 9.5 billion United State dollar (USD) in 2018 to 15 billion USD in 2050, resulting a 1.59-fold increase. A 2%–3% decrease in incidence rate of hip fracture annually is required to keep the total number of hip fracture constant over time.ConclusionsThe results show that hip fracture remains a key public health issue in Asia, despite the available of better diagnosis, treatment, and prevention of fracture over the recent years. Healthcare policy in Asia should be aimed to reduce the burden of hip fracture.

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Section: Methodsmentioning

confidence: 99%

“…[ 22 ] and Wang et al. [ 23 ] used International Classification of Diseases (ICD), 9th revision (ICD-9) of 820.XX (proximal femur fracture) and 820.XX to 821.XX (other femur fracture) to define hip fracture, respectively. To be conservative, we included both studies in the estimation of the total number of hip fracture.…”

Section: Methodsmentioning

confidence: 99%

An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study

Cheung

Ang

Chadha

et al. 2018

Osteoporosis and Sarcopenia

257

182

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“…The rationale for 1:4 matching for the haemophilia and control groups was based on sample size estimation. By using two‐sided confidence level (95%), power (80%), per cent of non‐haemophilia individuals with osteoporotic fractures (3.84%, which was based on the official record of prevalence of outcome during the age of 30‐39 in Taiwan) and the per cent of PWH with osteoporotic fractures (17.32%, which was based on the initial analysis from the national insurance database), the result showed that if we adopted a 1:1 ratio, the appropriate sample size should be higher than 95 participants in each group. Therefore, we adjusted the ratio of the unexposed to the exposed group from 1 to 4, resulting in an approximate sample size of 50 and 200 participants in the haemophilia and control groups, respectively.…”

Section: Resultsmentioning

confidence: 99%

Risk of osteoporotic fractures as a consequence of haemophilia: A nationwide population‐based cohort study

Tuan

Sun

et al. 2019

Haemophilia

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Aim: Low bone mineral density occurs more commonly in patients with haemophilia (PWH) than the general population. However, the risk of haemophilia-related osteoporotic fractures has not been well established. We aim to explore the relationship between haemophilia and the development of osteoporotic fractures following haemophilia. Methods:This was a nationwide population-based cohort study based on the data in the Taiwan National Health Insurance Research Database (TNHIRD). Patients who were diagnosed with haemophilia were selected. A comparison cohort was formed of patients without haemophilia who were matched according to age and sex. The incidence rate and the hazard ratios (HRs) of new-onset osteoporotic fractures were calculated for both cohorts. Results:The haemophilia cohort consisted of 75 patients, and the comparison cohort comprised 300 matched control patients without haemophilia. The risk of osteoporotic fractures was higher in the haemophilia cohort than in the comparison cohort (HR = 5.41, 95% confidence interval [CI] = 2.42-12.1, P < 0.001). After adjustments for age, sex, comorbidities, urbanizations and socio-economic status, PWH were 4.37 times more likely to develop osteoporotic fractures (95% CI = 1.88-10.17, P = 0.001) as compared to matched cohort. In addition, the incidence of newly diagnosed osteoporotic fractures was significantly increased after 5-year follow-up durations.Conclusion: Though our study by TNHIRD presented methodologic flaws by its design nature, we observed that haemophilia may increase the risk of osteoporotic fractures and the cumulative incidence was significantly higher for PWH diagnosed more than 5 years. Clinicians should pay particular attention to osteoporotic fractures following haemophilia in PWH as they age. K E Y W O R D S cumulative incidence, haemophilia, National Health Insurance Research Database, osteoporotic fracture | 877 TUAN eT Al.

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“…Osteoporosis has been associated with increased mortality and decreased health-related quality of life 6–8. Results from the National Health Insurance Research Database show that the annual direct medical costs of osteoporosis patients increased steadily in Taiwan from 2009 to 2013 9. It is predicted that by 2050 the annual costs of osteoporosis-related fractures will increase to $25.43 billion in China 5…”

Section: Introductionmentioning

confidence: 99%

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Qiao

Liu

et al. 2020

BMJ Open

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ObjectiveThe aims of this study were to describe distributions of the prevalence of osteopenia and osteoporosis and identify the potential risk factors by gender in a Chinese rural population.DesignA cross-sectional survey.Setting and participantsA total of 8475 participants (18–79 years) were obtained from the Henan Rural Cohort Study. Bone mineral density (BMD) of the calcaneus for each individual was measured by ultrasonic bone density apparatus. Logistic regression models were used to evaluate associations of potential risk factors with prevalence of osteopenia and osteoporosis. Furthermore, a meta-analysis of prevalence of osteoporosis which included eight studies was conducted to confirm this study results.ResultsThe mean of BMD were 0.42 and 0.32 g/cm2for men with osteopenia and osteoporosis (p<0.001), as well as 0.40 and 0.30 g/cm2(p<0.001) for women with osteopenia and osteoporosis, respectively. The overall age-standardised prevalence of osteopenia and osteoporosis were 42.09% and 11.76% in all participants. The age-standardised prevalence of osteopenia in men (45.98%) was significantly higher than that in women (39.73%), whereas the age-standardised prevalence of osteoporosis in men (7.82%) was lower than that in women (14.38%). Meta-analysis results displayed pooled prevalence of osteoporosis of 18.0% (10.1%–25.8%) in total sample, 7.7% (5.7%–9.7%) in men and 22.4% (17.1%–27.6%) in women. Multivariable logistic regression models showed that ageing, women, low education level or income, drinking or underweight was related to increased risk for osteopenia or osteoporosis.ConclusionsAbout one-sixth of the participants suffered osteoporosis in rural China, and the prevalence in women was higher than men. Although the results were lower than that of meta-analysis, osteoporosis still accounts for huge burden of disease in rural population due to limited medical service and lack of health risk awareness rather than urban area.Trial registration numberChinese Clinical Trial Registry (ChiCTR-OOC-15006699; Pre-results).

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Age- and gender-specific epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture in Taiwan between 2009 and 2013

Cited by 25 publications

References 25 publications

An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study

An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study

Risk of osteoporotic fractures as a consequence of haemophilia: A nationwide population‐based cohort study

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

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