Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study

Skaug, Eli-Anne; Aspenes, Stian Thoresen; Oldervoll, Line Merethe; Mørkedal, Bjørn; Vatten, Lars J.; Wisløff, Ulrik; Ellingsen, Øyvind

doi:10.1177/2047487312444234

Cited by 98 publications

(98 citation statements)

References 40 publications

(54 reference statements)

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“…Some of the FMD studies also assessed EMD but the apparent difference between BD and controls was offset by wide statistical heterogeneity. While EMD depends on exogenous nitric oxide for the relaxation of smooth muscle cells within the vasculature, FMD relies mostly on the biological activity of endogenous nitric oxide which may be impaired both in relation to disease activity [42] and to type vascular involvement [43] in BD and shows age and sex dependency [44].…”

Section: Discussionmentioning

confidence: 99%

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Merashli¹,

Ster

Ames

2016

Seminars in Arthritis and Rheumatism

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Section: Discussionmentioning

confidence: 99%

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Merashli¹,

Ster

Ames

2016

Seminars in Arthritis and Rheumatism

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“…His FMD is 3% below the mean of a Norwegian reference population, but he has a large baseline diameter and no indication of endothelial dysfunction, because his FMD is above 0% [24]. His blood biomarkers were also normal and low for his age as was his blood pressure, with no indication of elevated cardiovascular risk markers.…”

Section: Discussionmentioning

confidence: 99%

How to Be 80 Year Old and Have a VO_2maxof a 35 Year Old

Karlsen

Leinan

Bækkerud

et al. 2015

Case Reports in Medicine

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Background. To discuss the cardiovascular and pulmonary physiology and common risk factors of an 80-year-old man with a world record maximal oxygen uptake of 50 mL·kg−1·min−1. Methods. Case report. Results. His maximal oxygen uptake of 3.31 L·min−1, maximal heart rate of 175 beats·min−1, and maximal oxygen pulse of 19 mL·beats−1 are high. He is lean (66.6 kg) and muscular (49% skeletal muscle mass). His echo parameters of mitral flow (left ventricular filling, E = 82 cm·s−1 and E/A = 1.2) were normal for 40- to 60-year-old men. Systolic and diastolic function increased adequately during exercise, with no increase in left ventricular filling pressure. He has excellent pulmonary function (FVC = 4.31 L, FEV1 = 3.41, FEV1/FVC = 0.79, and DLCO = 12.0 Si1) and normal FMD and blood volumes (5.8 L). He has a high level of daily activity (10,900 steps·day−1 and 2:51 hours·day−1 of physical activity) and a lifelong history of physical activity. Conclusion. The man is in excellent cardiopulmonary fitness and is highly physically active. His cardiac and pulmonary functions are above expectations for his age, and his VO2max is comparable to that of an inactive 25-year-old and of a normal, active 35-year-old Norwegian man.

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“…Because age and gender are important factors determining endothelial function 39) , the gender imbalance and the age distribution in this study should be noted in the generation of the results. Despite these limitations, 3 months of 20 mg/d lutein supplementation increased serum lutein and decreased serum inflammatory cytokines and serum TG and LDL-cholesterol.…”

Section: Resultsmentioning

confidence: 99%

Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population

Zou

Xiao

et al. 2013

JAT

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Aim:The purpose of this study was to determine the effects of lutein supplement on serum cytokines, apoE and lipoprotein profiles in early atherosclerosis population. Methods: Early atherosclerosis patients (n = 65) were randomized to receive placebo (A＋P, n = 31) or 20 mg/d lutein (A＋L, n = 34) for 3 months. Results: Serum lutein increased significantly compared to baseline after lutein supplements in A+L group (p＜0.001). Lutein supplements resulted in a significant decrease in serum interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP- 1 IntroductionAtherosclerosis is a pathologic status that underlies several important adverse vascular events, such as coronary disease, stroke, and peripheral arterial problems 1) . It has become the leading cause of cardiovascular morbidity and mortality in western societies, accounting for a fifth of deaths worldwide 2) . While the use of established medical therapies has reduced mortality from its complications, the adoption of a western lifestyle has led to a large increase in the prevalence of atherosclerosis throughout the world 3); therefore, the prevention of atherosclerosis remains a major public health challenge for both China and for western countries. Atherosclerosis is an inflammatory disease 4) . Inflammation is a key regulatory process that links multiple risk factors for atherosclerosis and its complications 5) . Oxidized low density lipoprotein (oxLDL) induces endothelial dysfunction and recruits monocytes and lymphocytes, initiating the development of atherosclerosis lesions. Thereafter, cytokines and chemokines secreted by activated macrophages perpetuate and amplify inflammatory responses 6) . In atherosclerosis patients, the extent of inflammatory infiltrates and their strategic location within protective fibers is associated with plaque rupture and/or thrombosis 7) . Furthermore, circulating inflammatory biomarkers, especially C-reactive protein, have been found to be associated with outcomes of cardiovascular events, even in the absence of dyslipidaemia 8) . These findings support the inflammatory nature of atherosclerosis; therefore, there is a hypothesis that antioxidants such as carotenoids could be used as an inexpensive means of the prevention and possibly treatment of atherosclerosis and its complications.Lutein, one of the most abundant carotenoids in 171Lutein Supplement and Early Atherosclerosis mission of Peking University Health Science Department and all participants gave written informed consent. Lutein Sources and Study DesignsStudy substances were suspended in wild camellia oil and given in acid-soluble gelatin capsules. A placebo containing wild camellia oil (100%) was supplied in identical-looking capsules. All the subjects were instructed to consume one capsule per day immediately after lunch and to store the study substance at room temperature. All participants were encouraged to maintain their usual lifestyle and dietary habits. Compliance was assessed at the end of the study using pill counting, food reco...

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Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study

Cited by 98 publications

References 40 publications

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

How to Be 80 Year Old and Have a VO_2maxof a 35 Year Old

Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population

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Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study

Cited by 98 publications

References 40 publications

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

How to Be 80 Year Old and Have a VO2maxof a 35 Year Old

Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population

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Product

Resources

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How to Be 80 Year Old and Have a VO_2maxof a 35 Year Old