Age and gender differences in symptom intensity and symptom clusters among patients with metastatic cancer

Cheung, Winson Y.; Le, Lisa W.; Gagliese, Lucia; Zimmermann, Camilla

doi:10.1007/s00520-010-0865-2

Cited by 131 publications

(136 citation statements)

References 54 publications

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“…Nausea, vomiting and diarrhea were also symptoms where gender differences were observed [4,9,15,[17][18][19][20]. Throughout the studies that examined nausea and vomiting in relation to gender, all studies concluded that these two symptoms occurred more frequently in female advanced cancer patients [4,9,15,[17][18][19]. Donnelly et al also found that female gender was associated with greater severity of these symptoms [3].…”

Section: Resultsmentioning

confidence: 99%

“…As such, these findings suggest that health care professionals should take into consideration the multidimensionality of pain by combining emotional counseling with other treatments, especially for female patients. For nausea and vomiting, although the increased frequency seen in females in the advanced cancer population is generally agreed upon and this prevalence is also common to other disorders, its' mechanism is still uncertain [4,9,15,[17][18][19][20]. Symptoms such as dyspnea, decreased appetite, drowsiness, sleep problems, hoarseness, diarrhea, constipation and others were all found to have gender difference in experience.…”

Section: Discussionmentioning

confidence: 99%

“…Gender appears to impact many elements of human nature, thus it is not unreasonable to hypothesize that there may be gender differences in oncology, specifically the symptoms experienced by palliative care cancer patients [6][7][8][9]. Studies specifically on gender differences in oncology symptoms have been rare [9]. The purpose of this review is to identify reported gender differences in symptoms experienced by palliative care cancer patients.…”

Section: Introductionmentioning

confidence: 99%

“…As such, understanding the factors that may influence the symptoms experienced by patients may assist palliative care physicians in better management of quality of life. Gender appears to impact many elements of human nature, thus it is not unreasonable to hypothesize that there may be gender differences in oncology, specifically the symptoms experienced by palliative care cancer patients [6][7][8][9]. Studies specifically on gender differences in oncology symptoms have been rare [9].…”

Section: Introductionmentioning

confidence: 99%

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Gender differences in symptoms experienced by advanced cancer patients: a literature review

Wong

Bedard

Pulenzas

et al. 2013

RHC

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INTRODUCTION: Advanced cancer patients are multi-symptomatic and require attentive palliative care. As gender differences are apparent in multiple aspects of everyday life, this literature review aims to determine the gender differences seen in the population of advanced cancer patients and the symptoms that they experience. METHODS: A literature review was conducted using the OvidSP Medline database from 1946 to November 2012. Randomized, prospective or retrospective cohort studies on advanced cancer patients who were undergoing any type of palliative treatments (palliative radiation, chemotherapy) or those in which palliative treatments have failed (antalgic treatment) were included. The patient population, tools/questionnaire used and gender differences in symptoms found statistically or qualitatively significant in the respective studies were extracted. RESULTS: Of the 163 studies resulting from the literature search, nineteen publications were identified. Gender differences in multiple symptoms were discovered. Gender differences were commonly found in symptoms of emotional changes, fatigue, gastrointestinal symptoms (nausea, vomiting, and diarrhea) anxiety, tension, sleep problems and pain. CONCLUSION: At present, gender differences seen in the symptoms experienced by advanced cancer patients continues to be inconclusive. Further study investigating gender differences in the symptoms experienced by advanced cancer patients as the primary endpoint is recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Wong

Bedard

Pulenzas

et al. 2013

RHC

View full text Add to dashboard Cite

show abstract

“…This cutoff was based on the findings that indicate cancer mortality rates are increasing in those aged older than 60 years 17 and is consistent with other large studies in this field. 18,19 Symptom Clusters Study. This prospective, longitudinal study was designed to identify symptom clusters and their effects on physical and psychological functioning of patients with metastatic disease.…”

Section: Study Samplesmentioning

confidence: 99%

Differences in Composition of Symptom Clusters Between Older and Younger Oncology Patients

Yates

Miaskowski

Cataldo

et al. 2015

Journal of Pain and Symptom Management

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Population-Level Symptom Assessment Following Pancreaticoduodenectomy for Adenocarcinoma

et al. 2019

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; and the Pancreas Cancer Population Outcomes Research Group IMPORTANCE Postoperative morbidity associated with pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PA) remains as high as 70%. However, to our knowledge, few studies have examined quality of life in this patient population. OBJECTIVE To identify symptom burden and trajectories and factors associated with high symptom burden following PD for PA. DESIGN, SETTING, AND PARTICIPANTS This population-based cohort study of patients undergoing PD for PA diagnosed between 2009 and 2015 linked population-level administrative health care data to routinely prospectively collected Edmonton Symptom Assessment System (ESAS) scores from 2009 to 2015, with a data analysis undertaken in 2018. EXPOSURES Baseline characteristics, including age, sex, income quintile, rurality, immigration status, and comorbidity burden, as well as treatment characteristics, including year of surgery and receipt of chemotherapy. MAIN OUTCOME AND MEASURES The outcome of interest was moderate to severe symptoms (defined as ESAS Ն4) for anxiety, depression, drowsiness, lack of appetite, nausea, pain, shortness of breath, tiredness, and impaired well-being. The monthly prevalence of moderate to severe symptoms was presented graphically for each symptom. Multivariable regression models identified factors associated with the reporting of moderate to severe symptoms. RESULTS We analyzed 6058 individual symptom assessments among 615 patients with PA who underwent resection (285 women [46.3%]) with ESAS data. Tiredness (443 [72%]), impaired well-being (418 [68%]), and lack of appetite (400 [65%]) were most commonly reported as moderate to severe. The proportion of patients with moderate to severe symptoms was highest immediately after surgery (range, 14%-66% per symptom) and decreased over time, stabilizing around 3 months (range, 8%-42% per symptom). Female sex, higher comorbidity, and lower income were associated with a higher risk of reporting moderate to severe symptoms. Receipt of adjuvant chemotherapy was not associated with the risk of moderate to severe symptoms. CONCLUSIONS AND RELEVANCE There is a high prevalence of symptoms following PD for PA, with improvement over the first 3 months following surgery. In what to our knowledge is the largest cohort reporting on symptom burden for this population, we have identified factors associated with symptom severity. These findings will aid in managing patients' perioperative expectations and designing strategies to improve targeted symptom management.

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Age and gender differences in symptom intensity and symptom clusters among patients with metastatic cancer

Abstract: In patients with advanced cancers, symptom patterns differ according to age and gender. Palliative interventions tailored for symptoms that are more prominent in specific patient subgroups may offer greater therapeutic benefit.

Cited by 131 publications

References 54 publications

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Differences in Composition of Symptom Clusters Between Older and Younger Oncology Patients

Population-Level Symptom Assessment Following Pancreaticoduodenectomy for Adenocarcinoma

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