Age- and Gender-Dependency of Left Ventricular Geometry Assessed with Real-Time Three-Dimensional Transthoracic Echocardiography

Kaku, Kyoko; Takeuchi, Masaaki; Otani, Kyoko; Sugeng, Lissa; Nakai, Hiromi; Haruki, Nobuhiko; Yoshitani, Hidetoshi; Watanabe, Nozomi; Yoshida, Kiyoshi; Otsuji, Yutaka; Mor‐Avi, Victor; Lang, Roberto M.

doi:10.1016/j.echo.2011.01.011

Cited by 73 publications

(89 citation statements)

References 24 publications

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“…However, several studies in patients with HFpEF have performed detailed examinations using echocardiography and/or cardiac magnetic resonance imaging. The results demonstrated that LV systolic function is impaired in patients with much higher LVEF levels than LVEF 50% 3, 4, 5. In addition, we previously reported loss of inertia force of late systolic aortic flow (IFLAF), which was obtained by using a catheter‐tipped micromanometer in cardiac catheterization, as a predictor of development of HF in patients with preserved LVEF 6.…”

Section: Introductionmentioning

confidence: 92%

The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub‐analysis of the J‐MELODIC study

et al. 2017

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AimsCardiac function varies in the population of patients with heart failure (HF) with preserved left ventricular ejection fraction (LVEF; HFpEF). This study investigated the heterogeneity of clinical features associated with HF and the prognostic value of BNP levels in patients with HFpEF.Methods and resultsThe study enrolled 288 patients with stable HF and serum creatinine <1.5 mg/dL who were part of the original J‐MELODIC study cohort. They were categorized as having HF with reduced LVEF (HFrEF; EF ≤ 40%, n = 83) or as having HFpEF (EF > 40%, n = 205). Patients with HFpEF were further categorized as having relatively low LVEF (HFrlEF; EF 40–60%, n = 107) or as having relatively high LVEF (HFrhEF; EF ≥ 60%, n = 98). We defined cardiovascular death and hospitalization for HF as adverse events and evaluated the prognostic value of the BNP levels in each group. There was no significant difference in event‐free survival between HFpEF and HFrEF patients or between HFrhEF and HFrlEF patients. A multivariate Cox proportional hazards model revealed that the BNP level was an independent predictor of adverse events in HFrEF patients (hazard ratio: 4.088, 95% confidence interval: 1.178–14.179, P = 0.027) and in HFrlEF patients (hazard ratio: 14.888, 95% confidence interval: 4.969–44.608, P < 0.001) but not in HFrhEF patients (P = 0.767).ConclusionsThe BNP level has prognostic value in HFrlEF but not in HFrhEF. This indicates that HFrhEF and HFrlEF are distinct entities that may require different approaches for the management of HF.

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Section: Introductionmentioning

confidence: 92%

The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub‐analysis of the J‐MELODIC study

et al. 2017

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“…Kaku et al recently investigated the growing process of LV geometry in 280 healthy subjects, between the age of 1 to 88 years. 27 These subjects were enrolled in Japan and the USA. Because of the race differences in the heart, 3-6,26 the use of their results as the Japanese reference values might be limited.…”

Section: Relationship To Age Gender and Racementioning

confidence: 99%

Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population

Fukuda

Watanabe

Daimon

et al. 2012

Circ J

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“…Real-time 3D echocardiography has proven useful for assessing LV mechanics because of its high feasibility rate of data acquisition, its relatively low observer and test-retest variability, and widely available and convenient semiautomated offline analysis. 7,8 Several promising approaches to quantifying dyssynchrony have been reported. [9][10][11][12] It is a new technique that allows accurate measurement of the volume and timing of regional changes.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Real‐time 3‐Dimensional Echocardiography to Identify and Quantify Left Ventricular Dyssynchrony in Patients With Kawasaki Disease

Kim

Han

et al. 2013

J of Ultrasound Medicine

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dvances in echocardiographic techniques, ie, real-time 3-dimensional (3D) echocardiography, tissue Doppler echocardiography, and speckle-tracking echocardiography, have recently shown impaired left ventricular (LV) synchronicity in patients with systolic dysfunction. 1,2 In addition, LV dyssynchrony is a phenomenon extensively described and related to impaired LV systolic function and poor prognoses. 3 Kawasaki disease affects mainly medium-sized arteries, with a particular predilection for the coronary Yi Yu, MD, Kun Sun, PhD, Haihong Xue, PhD, Sun Chen, PhD, Jianping Yang, MD Received June 25, 2012, Methods-Forty patients hospitalized for Kawasaki disease were analyzed retrospectively, and 40 sex-and age-matched healthy control volunteers were also enrolled. The systolic dyssynchrony index (percentage of the cardiac cycle) from 16 and 12 LV segments on real-time 3D echocardiography was analyzed to calculate LV dyssynchrony (defined as the standard deviation of the time to reach the minimum systolic volume for 16 LV segments) according to a 17-segment model. We analyzed the 3D LV ejection fraction (LVEF), end-diastolic volume, and end-systolic volume in the patients with Kawasaki disease compared to the controls.Results-The 16-segment systolic dyssynchrony index ± SD was significantly higher in the patients with Kawasaki disease: 2.73% ± 0.96% compared to 2.01% ± 0.85% in the controls (P < .05). The 12-segment systolic dyssynchrony index in the patients with Kawasaki disease was 2.65% ± 0.93% compared to 1.98% ± 0.81% in the controls (P< .05). Patients with Kawasaki disease and an LVEF of less than 50% had a significantly higher systolic dyssynchrony index compared to patients with an LVEF of 50% or greater (2.89% ± 0.79% versus 2.26% ± 0.73%; P < .05). The LVEF measured by echocardiography was decreased in the patients with Kawasaki disease, and global systolic function was impaired. The LVEF measured by a biplane method was sufficiently related to the LVEF measured by echocardiography.Conclusions-Real-time 3D echocardiography is a noninvasive and feasible method for identifying and evaluating LV dyssynchrony in children with Kawasaki disease. Left ventricular dyssynchrony is significantly impaired and related to LV systolic function in patients with Kawasaki disease.

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Age- and Gender-Dependency of Left Ventricular Geometry Assessed with Real-Time Three-Dimensional Transthoracic Echocardiography

Cited by 73 publications

References 24 publications

The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub‐analysis of the J‐MELODIC study

The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub‐analysis of the J‐MELODIC study

Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population

Usefulness of Real‐time 3‐Dimensional Echocardiography to Identify and Quantify Left Ventricular Dyssynchrony in Patients With Kawasaki Disease

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