Age‐ and disease‐related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming
Chuyang Luo,
Junsheng Yang
Abstract:Autophagy impairment in Huntington disease (HD) has been reported for almost two decades. However, the molecular mechanisms underlying this phenomenon are still unclear. This is partially because it is challenging to model the impact of the disease‐causing mutation, aging, as well as the selective vulnerability of neurons in a single model. Recently developed direct neuronal reprogramming that allows researchers to induce neurons‐of‐interest retaining biological aging information made it possible to establish … Show more
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