Age and Comorbidities Affect Quality of Life in Patients With Osteoarthrtitis and Knee Replacement

Fernández-Cuadros, Marcos Edgar; Pérez-Moro, Olga Susana; Mirón-Canelo, José Antonio

doi:10.17795/mejrh-40247

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…The osteoarthritis research society international has suggested non-pharmacological, pharmacological, and surgical recommendations for the treatment/management of knee OA (2). Total knee arthroplasty is the last alternative in advanced knee OA patients, and although it is an invasive and expensive procedure with a 95% rate of survival at 10 years, it might have complications (4,17,18).…”

Section: Introductionmentioning

confidence: 99%

Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2018

Middle East J Rehabil Health Stud

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Objectives: The aim of this study was to evaluate if ozone is capable of decreasing biomarkers of inflammation (CRP/ESR) and pain, and to improve function and quality of life in knee osteoarthrtitis (OA) patients. Methods: A prospective quasi experimental (before-and-after study) research was performed to investigate the effect of Ozone therapy protocol. The intervention included 4 sessions (1 session/week) of an intra-articular infiltration of a medical mixture of Oxygen-Ozone (95% to 5%) at 20 ug/mL concentration. Biochemical evaluation (CRP and ESR), pain VAS, and WOMAC scales were evaluated before and after the treatment. Results: Overall, 33 patients were evaluated. Mean age was 68.18 ± 8.43 years. Female patients accounted for 75.7% (n = 25) and male patients corresponded to 24.3% (n = 8). Female: male ratio was 3:1. The most frequent radiological KL grade was 2º (n = 22, 66.7%), followed by 3º (n = 8, 24.2%), and 4º (n = 3, 9.1%). Biomarkers of inflammation decreased significantly. C-reactive protein (CRP) diminished from 0.33 ± 0.32 mg/dL to 0.25 ± 0.23 mg/dL (P = 0.0456). Erythrocyte sedimentation rate (ESR) decreased from 15.06 ± 12.09 mm/h to 11.81 ± 8.32 mm/h (P = 0.01). Before treatment, pain measured by VAS was 7.33 ± 1.31 points and decreased to 2.84 ± 1.76 (P < 0.0001). The WOMAC-pain subscale was 14.84 ± 2.77 points and diminished to 5.96 ± 3.53 (P < 0.0001), WOMAC stiffness subscale was 3.06 ± 1.95 points and ameliorated to 1.15 ± 1.3 (P < 0.0001), WOMAC-function subscale was 41.15 ± 12.58 points and decreased to 22.3 ± 11.64 (P < 0.0001). Conclusions: Ozone is capable of both decreasing pain and stiffness and improving function and quality of life in knee OA patients, yet decreases biomarkers of inflammation, such as CRP and ESR.

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Section: Introductionmentioning

confidence: 99%

Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2018

Middle East J Rehabil Health Stud

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“…39,42,43 Forogh et al 19 sustain that some studies have reported an inverse relationship between age and response to treatment; in younger patients the outcome was better than those over 50 years. 44 Fernández-Cuadros et al have stated that age is related to knee OA severity and outcomes are dependent on such variable. 3,44 There is only one study that shows benefit on older patients with even 3º grade knee OA.…”

Section: Discussionmentioning

confidence: 99%

“…44 Fernández-Cuadros et al have stated that age is related to knee OA severity and outcomes are dependent on such variable. 3,44 There is only one study that shows benefit on older patients with even 3º grade knee OA. 41 Our present study shows a clear correlation between age and knee severity and for the first time shows statistical significant improvement of PRP-protocol treatment in all K-L grades, even 4º grade, to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of platelet-rich plasma (PRP) on pain, function and quality of life in knee osteoarthritis patients: a before-and-after study and review of the literature

Fernández-Cuadros¹,

Pérez-Moro²,

Albaladejo-Florín³

et al. 2018

MOJOR

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Objective: To determine the effects on pain relief, function and quality of life in knee Osteoarthritis (OA) patients by a protocol of 3-doses of PRP injected weekly. Material and methods:A prospective quasi-experimental before-and-after study (non-randomized control trial) was performed on 27 patients with knee OA Kellgren-Lawrence (K-L) grade 2 or more, from January 2014 to February 2017, referred to the Rehabilitation Department at Santa Cristina's University Hospital. The symptoms severity was evaluated using the Western Ontario and Mac Master Universities Index for Osteoarthritis (WOMAC). The PRP-protocol consisted of 3-sessions (1 session/ week) of an intra articular infiltration of 3ml of platelet-rich plasma (PRP). To get the PRP, Accelerate Concentration System Device® from EXACTECH, EmCyte Anticoagulant Sodium Citrate Solution U.S.P. and Drucker Centrifuge (Series Performance) were used. Results:The mean age of the sample was 58.03±10.91 years. Before intervention, pain measured by VAS was 8.14±1.09 and decreased significantly to 2.96 (p=0.000) after treatment. Prior to treatment, WOMAC Pain Sub-scale was 14.88±7.02 and decreased to 5.55±6.87 points (p=0.000); WOMAC Stiffness sub-scale was 2.44±3.33 and diminished to 0.4±0.4 points (p=0.000); and WOMAC Function sub-scale was 44.48±12.27 and ameliorated to 15.25±12.38 points (p=0.000). As adverse effects, one patient presented important pain and inflammation after PRP infiltration (3.44%). Conclusion:PRP Infiltrated in a 3-doses protocol is effective in the treatment of knee OA symptoms such as pain and stiffness, improving function and QoL. PRP alleviates knee OA symptoms in all radiological knee OA grades, even the most severe ones and with statistical difference.

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“…Comorbidities are defined as diseases or medical conditions which do not relate causally to the primary diagnosis but coexist with it. Elderly patients generally have more comorbidities but the effects of comorbidities on the results of arthroplasty need to be further studied (3). In a medical environment, classifying comorbidities using valuebased metrics can help improve pre-surgical counseling, decrease potential complications and allow for perioperative resources to be properly assigned.…”

Section: Introductionmentioning

confidence: 99%

Predictors of 30-Day Re-hospitalization After Total Hip and Total Knee Arthroplasty: A Orthopedic Ward Perspective

Gelişgen

Özyürek

2022

Clinical and Experimental Health Sciences

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Objective:The study was aimed to elucidate risk factors identifiable from ward-derived data of thirty-day re-hospitalization among patients undergoing total hip and total knee arthroplasty. Methods:The study was designed as a cross-sectional and prospective study. The data of the study were collected through the Patient Sociodemographic Form, the Nurse Physical Assessment and Observation Form, the Charlson Comorbidity Index (CCI), and the Katz Activities of Daily Living (ADL) Scale.Results: Patients were scored using this CCI system and grouped as high (high CCI group >2, n = 49) and low CCI (low CCI group ≤2, n = 78) with a cut-off score of 2. The 30-day re-hospitalization rate was 14.2%, and the most common reason for re-hospitalization was a surgical infection. Surgical risk, Activities of daily living dependency, and comorbidities index scores of the patients were not significantly additive effects on rehospitalization (p> 0.05). The results indicate that surgical infection was often the cause of higher rates of re-hospitalization among patients with total knee and total hip arthroplasty.Conclusions: Orthopedic nurses should close observation of surgical site infection and design an effective discharge following-up order to the prevention of re-hospitalization in patients with"high risk".

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Age and Comorbidities Affect Quality of Life in Patients With Osteoarthrtitis and Knee Replacement

Abstract: Background: Osteoarthritis (OA) is a multifactorial, disabling and degenerative disease that worsens with age and affects patient's health-related quality of life (HRQOL).

Cited by 8 publications

References 21 publications

Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature

Ozone Decreases Biomarkers of Inflamation (C-Reactive Protein and Erytrocyte Sedimentation Rate) and Improves Pain, Function and Quality of Life in Knee Osteoarthrtitis Patients: A Before-and-After Study and Review of the Literature

Effectiveness of platelet-rich plasma (PRP) on pain, function and quality of life in knee osteoarthritis patients: a before-and-after study and review of the literature

Predictors of 30-Day Re-hospitalization After Total Hip and Total Knee Arthroplasty: A Orthopedic Ward Perspective

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