Age and Cancer Risk

Abstract

This article challenges the idea that cancer cannot be prevented among older adults by examining different aspects of the relationship between age and cancer. Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be. For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer. Midlife is a period of life when the prevalence of multiple cancer risk factors is high and incidence rates begin to increase for many types of cancer. However, current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer. Because the number of adults reaching older ages is increasing rapidly, the number of new cancer cases will also increase if current incidence rates remain unchanged. Thus, the need to translate the available research into practice to promote cancer prevention, especially for adults at midlife, has never been greater.

MethSurv: A Web Tool to Perform Multivariable Survival Analysis Using DNA Methylation Data

“…A total of 25 different cancer datasets including 7358 methylomes passed our selection criteria. Since age, sex and BMI are associated with both methylation changes [28][29][30] and cancer progression [31][32][33][34], these were used as covariates in the multivariable prediction models. In addition, we also considered all potentially relevant cancer specific features including cancer stage, grade and HER2, estrogen receptor (ER) and progesterone receptor (PR) status by immunohistochemistry for breast cancer and pathologically determined lymph node metastasis status for uveal melanoma as covariates (Supplementary Table 1).…”

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case‐control frequency‐matched study

“…We matched patients with RAS to those without RAS at a ratio of 1:1 through frequency matching. The potential cancer risk‐confounding factors of age,90 sex,91, 92 monthly insured income,93, 94 geographical region,95 and urbanization level96 were considered and matched (Table 1). As listed in Table 1, all P values were near 1, thereby demonstrating that our matching results were satisfactory and the confounding factors were controlled effectively 89.…”

“…The risk ratios of cancers are similar in all patients with RAS, regardless age. Therefore, although cancer incidence is lower among younger patients (<40 years old) than among older patients,90 physicians should remain alert to the risk of the previously mentioned cancers in all patients with RAS.…”

Morbidade Psicológica E Implicações Para a Recuperação De Adultos Após Cirurgia Oncológica

“…A média de idade encontrada (59 anos; DP=14) corrobora com os dados da literatura; a incidência de neoplasias malignas aumenta a partir dos 50 anos de idade (15) . Os tipos de neoplasias malignas mais incidentes, na região da América Latina e do Caribe, são os cânceres de próstata (152 mil) e mama feminina (150 mil) (3) .…”