Age- and body mass index-related differences in the prevalence of metabolic syndrome in women with polycystic ovary syndrome

Panidis, Dimitrios; Τζιόμαλος, Κωνσταντίνος; Macut, Djuro; Kandaraki, Eleni; Tsourdi, Elena; Papadakis, Efstathios; Katsikis, Ilias

doi:10.3109/09513590.2013.819079

Cited by 15 publications

(36 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the data of the RT-PCR analysis did not confirm the FOS downregulation in SCAAT from obese compared to lean. In addition to this, Chazenbalk et al [79] and Jones et al [80] have recently reported an underexpression of FOS and JUN in women with Polycystic Ovary Syndrome, a disease often accompanied by obesity [81,82], agreeing with our results found in young male subjects. Moreover, CITED2 a member of the cited family of nuclear regulators and NR3C1 were downregulated (Table 2).…”

Section: Resultssupporting

confidence: 93%

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

González‐Muniesa

Marrades

Martínéz

et al. 2013

IJMS

View full text Add to dashboard Cite

The current nutritional habits and lifestyles of modern societies favor energy overloads and a diminished physical activity, which may produce serious clinical disturbances and excessive weight gain. In order to investigate the mechanisms by which the environmental factors interact with molecular mechanisms in obesity, a pathway analysis was performed to identify genes differentially expressed in subcutaneous abdominal adipose tissue (SCAAT) from obese compared to lean male (21–35 year-old) subjects living in similar obesogenic conditions: habitual high fat dietary intake and moderate physical activity. Genes involved in inflammation (ALCAM, CTSB, C1S, YKL-40, MIF, SAA2), extracellular matrix remodeling (MMP9, PALLD), angiogenesis (EGFL6, leptin) and oxidative stress (AKR1C3, UCHL1, HSPB7 and NQO1) were upregulated; whereas apoptosis, signal transcription (CITED 2 and NR3C1), cell control and cell cycle-related genes were downregulated. Interestingly, the expression of some of these genes (C1S, SAA2, ALCAM, CTSB, YKL-40 and tenomodulin) was found to be associated with some relevant metabolic syndrome features. The obese group showed a general upregulation in the expression of inflammatory, oxidative stress, extracellular remodeling and angiogenic genes compared to lean subjects, suggesting that a given genetic background in an obesogenic environment could underlie the resistance to gaining weight and obesity-associated manifestations.

show abstract

Section: Resultssupporting

confidence: 93%

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

González‐Muniesa

Marrades

Martínéz

et al. 2013

IJMS

View full text Add to dashboard Cite

show abstract

“…Metabolic syndrome for adults was defined by different criteria, for example 25 articles used the Adult Treatment Panel III (ATP III) and its modifications criteria . Six articles used the American Heart Association/National Heart Lung Blood Institute (AHA) and its modification criteria . Four articles used the World Health Organization (WHO) criteria .…”

Section: Resultsmentioning

confidence: 99%

“…In 15 Articles, 9,18,22,23,25,27,32,[36][37][38]40,46,[48][49][50] PCOS was defined by the National Institute of Health as the presence of two of three criteria of chronic anovulation, clinical and/or biochemical signs of hyperandrogenism with the exclusion of other etiologies. 51 Also, 27 articles 8,[13][14][15][16][18][19][20]24,26,[28][29][30][31][33][34][35][41][42][43][44][45][52][53][54][55][56] used the criteria of the European Society for Human Reproduction and Embryology/ American Society for Reproductive Medicine (ESHRE/ASRM) diagnostic criteria as two of the three criteria of hyperandrogenism, polycystic ovaries on ultrasound (PCO) and irregular anovulatory periods. 57 Four articles 8,18,39,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Metabolic syndrome for adults was defined by different criteria, for example 25 articles [14][15][16]20,21,[24][25][26]29,30,32,33,[35][36][37]39,41,45,46,[48][49][50]52,54,55 used the Adult Treatment Panel III (ATP III) and its modifications criteria. 61 Six articles 15,20,24,35,40,56 Full-text articles excluded based on lack of clear data (n = 1)…”

Section: Study Characteristicsmentioning

confidence: 99%

“…62 Four articles 20,21,23,43 used the World Health Organization (WHO) criteria. 63 Thirteen articles 9,15,18,20,24,27,31,35,[38][39][40]42,49 used the International Diabetes Federation (IDF). 64 Five articles 8,15,28,35,58 used the Joint Interim Statement 65 .…”

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta‐analysis

Behboudi‐Gandevani

Amiri

Yarandi

et al. 2017

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

The Association Between Polycystic Ovary Syndrome and Metabolic Syndrome in Adolescents: a Systematic Review and Meta-analysis

Xie

et al. 2022

Reprod. Sci.

View full text Add to dashboard Cite

The association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS) is not widely recognized or properly assessed in adolescents. The aim of this study was to conduct a systematic review and meta-analysis to provide reliable results concerning MetS development in adolescents with PCOS. We searched studies published in PubMed, Medline, and Web of Science from January 2010 to December 2020. The quality of studies was assessed by the Newcastle–Ottawa Scale (NOS), and the data analysis was performed with Stata 14.0. Twelve articles were finally included in the systematic review and meta-analysis. The results suggested that adolescents with PCOS have more than three times the odds of having MetS than controls (OR 3.32, 95% CI [2.14, 5.14]). Obese adolescents with PCOS also had a higher risk of MetS than those with obesity but without PCOS (OR 3.97, 95% CI [1.49, 10.53]). Compared to those without PCOS, systolic blood pressure was higher in adolescents with PCOS (weighted mean difference (WMD) 3.85, 95% CI [1.73, 5.97]), while diastolic blood pressure was higher only in girls with PCOS who had a normal weight (WMD 3.52, 95% CI [1.57, 5.48]). The levels of triglycerides were higher in obese adolescents with PCOS than in those with obesity but without PCOS (WMD 27.84, 95% CI [10.16, 45.51]). PCOS could increase the frequency of MetS by influencing blood pressure and lipid metabolism independent of obesity as early as the adolescent period. Thus, clinicians should perform early interventions in adolescents with PCOS and follow up the relevant indicators of MetS to decrease the risk of poor long-term prognosis.

show abstract

Age- and body mass index-related differences in the prevalence of metabolic syndrome in women with polycystic ovary syndrome

Abstract: The prevalence of Mets appears to be primarily determined by obesity and age whereas PCOS per se appears to be a less important contributing factor.

Cited by 15 publications

References 28 publications

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

Differential Proinflammatory and Oxidative Stress Response and Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male Consumers Putatively Predisposed by Their Genetic Background

The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta‐analysis

The Association Between Polycystic Ovary Syndrome and Metabolic Syndrome in Adolescents: a Systematic Review and Meta-analysis

Contact Info

Product

Resources

About