Age and Assay Related Changes of Laboratory Thyroid Function Tests in the Reference Female Population

Barhanović, Najdana Gligorović; Antunović, Tanja; Kavaric, Sreten; Djogo, Aleksandar; Spasojević, V. K.

doi:10.2478/jomb-2018-0020

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…In this survey, 13,344 individuals with no family or personal history of thyroid disease, goiter, thyroid laboratory abnormality, and use of interfering medication but with positive TgAb and TPOAb were examined. Recent European studies showed a TSH RI of 0.44 to 4.13 mIU/L in women aged between 19 and 70 years (electrochemiluminescence method -Roche Diagnostics ® ) (24) and of 0.65 to 5.39 mIU/L in women aged between 20 and 69 years (chemiluminescent immunoassay -Architect i2000 platform, Abbott Laboratories ® ) (25).…”

Section: Discussionmentioning

confidence: 99%

Establishment of reference interval for thyroid-stimulating hormone using electrochemiluminescence assay in a healthy adult population from Fortaleza, Brazil

Gurgel¹,

Ponte²,

Fontes³

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: This study aimed to determine the thyroid-stimulating hormone (TSH) reference interval (RI) and to assess the influence of the use of thyroid ultrasonography (TUS) on reference individual selection from a healthy adult population in Fortaleza, Brazil. Subjects and methods: This crosssectional study recruited patients (N = 272; age = 18-50 years) with normal thyroid function (NTF) and placed them in three groups according to their test results: NTF (n = 272; all participants), TUS (n = 170; participants who underwent thyroid US), RI (n = 124; reference individuals with normal TSH levels). TSH, FT4, TT3, TgAb, and TPOAb concentrations were determined by electrochemiluminescence assay. TUS was performed using a 7-12 MHz multifrequency linear transducer by two radiologists. The 2.5 th and 97.5 th percentiles of the distribution curve corresponded to lower and upper TSH RI levels, respectively. Results: The mean TSH level was 1.74 ± 0.96 mIU/L, and TSH range was 0.56-4.45 mIU/L. There was no difference in the TSH concentrations between men and women nor between the groups. TUS did not appear to be an essential tool for the reference group selection. Conclusion: The upper limit of TSH was comparable to the reference interval provided by the assay manufacturer (4.45 vs. 4.20 mIU/L) but the lower limit was not (0.56 vs. 0.27 mIU/L). This finding may have a clinical impact since these values may lead to the misdiagnosis of euthyroid patients with subclinical hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

Establishment of reference interval for thyroid-stimulating hormone using electrochemiluminescence assay in a healthy adult population from Fortaleza, Brazil

Gurgel¹,

Ponte²,

Fontes³

et al. 2020

Archives of Endocrinology and Metabolism

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“…In order to assess the thyroid functioning, it is recommended to measure the level of thyroid-stimulating hormone (TSH) secreted by the pituitary gland and the free triiodothyronine (FT 3 ) and free thyroxine (FT 4 ) in the blood [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Electrotherapy Treatments Performed in the Area of the Throat and Larynx and the Level of TSH, FT3 and FT4 Hormones: A Randomized Controlled Trial

Zwolińska

Augustyn

Baj

et al. 2021

Preprint

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No current studies are available on application and side effects of potassium iodide iontophoresis. This study assessed the potassium iodide iontophoresis effect in the throat and larynx area on TSH, FT3 and FT4 hormone levels. Double-blinded randomized controlled trial with 1:1 parallel-group was conducted at the University of Rzeszow, Poland. A total of 50 healthy volunteers with normal TSH, FT3, FT4 levels without focal changes in the thyroid ultrasonography were subjected to 10 electrotherapy treatments (galvanization and iontophoresis groups). TSH, FT3, FT4 levels were determined before 10 treatments (test 1), 2 weeks after their completion (test 2) and after 6 months (test 3). In tests 2 and 3, both groups had normal levels of TSH, FT3, and FT4. No statistically significant differences between the galvanization and iontophoresis groups were found in terms of change of TSH, FT3, FT4 levels between tests 1 vs. 2 and 1 vs. 3. Both groups had lower levels of all measured parameters in test 3. Potassium iodide iontophoresis does not affect thyroid hormone levels in the short and long term. It is advisable to continue the follow-up study with larger groups to confirm the safety of electrotherapy procedures in the pharynx and larynx area.

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“…The two most common causes of hyperthyroidism are Graves' disease (GD) and toxic nodular goitre (1). The prevalence of hyperthyroidism is 0.8% in Europe and 1.3% in the USA (2,3).…”

Section: Introductionmentioning

confidence: 99%

Can Neutrophil/Lymphocyte Ratio Be Used as an Indicator of Inflammation in Patients with Hyperthyroidism?

Dağdeviren¹,

Akkan²,

Yapar³

et al. 2019

Journal of Medical Biochemistry

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In our study, we aimed to evaluate changes in the neutrophil and lymphocyte series and investigate whether the neutrophil/lymphocyte ratio (NLR) is indicative of inflammations in patients with hyperthyroidism. A total of 161 patients were enrolled, 121 of which had hyperthyroidism (71 Graves’ Disease (GD) and 50 non-Graves hyperthyroidism (NGH) patients) and 40 of which were control group members. Retrospectively, patients’ neutrophil and lymphocyte counts were taken, and the NLR was calculated. While the number of neutrophils was significantly lower in the GD group (p = 0.003), there was no significant difference between the NGH and the control group. In the GD group, NLR values were significantly lower than the other two groups (median 1.39 for GD, median 1.84 for NGH and median 1.83 for the control group, p < 0.001). Only three patients in the GD group had neutropenia. There was also a significant negative correlation between free T3 and neutrophil count and NLR in hyperthyroid patients (r = -0.28, p = 0.001 and r = -0.34, p < 0.001, respectively). In our study, we found that NLR did not in crease in hyperthyroid patients and that this ratio decreased due to the decrease in neutrophil levels in GD. We thus concluded that NLR is not a suitable indicator of hyperthyroidism.

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Age and Assay Related Changes of Laboratory Thyroid Function Tests in the Reference Female Population

Cited by 8 publications

References 39 publications

Establishment of reference interval for thyroid-stimulating hormone using electrochemiluminescence assay in a healthy adult population from Fortaleza, Brazil

Establishment of reference interval for thyroid-stimulating hormone using electrochemiluminescence assay in a healthy adult population from Fortaleza, Brazil

Electrotherapy Treatments Performed in the Area of the Throat and Larynx and the Level of TSH, FT3 and FT4 Hormones: A Randomized Controlled Trial

Can Neutrophil/Lymphocyte Ratio Be Used as an Indicator of Inflammation in Patients with Hyperthyroidism?

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