Age: An effect modifier of the association between allergic rhinitis and Otitis media with effusion

Roditi, Rachel E.; Veling, Maria C.; Shin, SM Jennifer J.

doi:10.1002/lary.25682

Cited by 33 publications

(28 citation statements)

References 32 publications

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“…A large body of work suggests a link between atopic disease and OM, and particularly COME. These associated atopic diseases include allergic rhinitis (Alles et al, 2001; Kreiner-Moller et al, 2012; Roditi et al, 2016), eczema (MacIntyre et al, 2010), and asthma (Gamble et al, 1992; Eldeirawi et al, 2010; MacIntyre et al, 2010; Bjur et al, 2012), but the same associations are not always reproduced between studies, leading to significant debate about the nature of these associations (Zernotti et al, 2017). Gamble et al (1992) hypothesized that COME in asthmatics is not an isolated disease, but instead represents an atopic disease affecting the mucociliary system of entire respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Altered Middle Ear Microbiome in Children With Chronic Otitis Media With Effusion and Respiratory Illnesses

Kolbe

Castro-Nallar

Preciado

et al. 2019

Front. Cell. Infect. Microbiol.

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Chronic otitis media with effusion (COME) is a common childhood disease characterized by an accumulation of fluid behind the eardrum. COME often requires surgical intervention and can also lead to significant hearing loss and subsequent learning disabilities. Recent characterization of the middle ear fluid (MEF) microbiome in pediatric patients has led to an improved understanding of the microbiota present in the middle ear during COME. However, it is not currently known how the MEF microbiome might vary due to other conditions, particularly respiratory disorders. Here, we apply an amplicon sequence variant (ASV) pipeline to MEF 16S rRNA high-throughput sequencing data from 50 children with COME (ages 3–176 months) undergoing tube placement. We achieve a more detailed taxonomic resolution than previously reported, including species and genus level resolution. Additionally, we provide the first report of the functional roles of the MEF microbiome and demonstrate that despite high taxonomic diversity, the functional capacity of the MEF microbiome remains uniform between patients. Furthermore, we analyze microbiome differences between children with COME with and without a history of lower airway disease (i.e., asthma or bronchiolitis). The MEF microbiome was less diverse in participants with lower airway disease than in patients without, and phylogenetic β-diversity (weighted UniFrac) was significantly different based on lower airway disease status. Differential abundance between patients with lower airway disease and those without was observed for the genera Haemophilus, Moraxella, Staphylococcus, Alloiococcus, and Turicella. These findings support previous suggestions of a link between COME and respiratory illnesses and emphasize the need for future study of the middle ear and respiratory tract microbiomes in diseases such as asthma and bronchiolitis.

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Section: Discussionmentioning

confidence: 99%

Altered Middle Ear Microbiome in Children With Chronic Otitis Media With Effusion and Respiratory Illnesses

Kolbe

Castro-Nallar

Preciado

et al. 2019

Front. Cell. Infect. Microbiol.

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“…3,5,6 However there is one study from Harvard medical school, which says the presence of AR increases the odds of otitis media with effusion, Eustachian tube dysfunction and tympanic membrane retraction in children more than 6 yrs old. 9 No further reference could be found in the literature where tympanic membrane retraction is studied in correlation with allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

“…Though allergic rhinitis is accepted as one of the leading causes of ET dysfunction and OME in many studies none of these studies include TM retraction as feature associated with AR. [3][4][5][6]9 Since Eustachian tube dysfunction will lead to negative middle ear pressure, TM retraction can develop in these patients. The reason for not seeing a statistically significant correlation between duration of symptoms and TM retraction may be due to the fact that these patients may have compromised ET function and thus retraction of TM only during exacerbation of symptoms and not as a persistent feature.…”

Section: Discussionmentioning

confidence: 99%

Observational study of tympanic membrane changes in allergic rhinitis

2016

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INTRODUCTIONApproximately 20% to 30% of total population suffers from at least one type of allergic diseases in India. A study carried, over 30 years ago in Delhi reported around 10% allergic rhinitis and 1% asthma in 1964.1 There after later studies have reported that 20% to 30% of the population suffer from allergic rhinitis and of that 15% develop asthma.Approximately 20% of adults and children have seasonal or perennial allergic rhinitis.2 Despite its prevalence, the condition is often treated inadequately and becomes chronic. A chronic state of nasal inflammation and obstruction develops, frequently leading to more serious complications in both the upper and the lower airways and the middle ear. 3The eustachian tube provides an anatomic communication between the nasopharynx and the middle ear and is in a unique position to cause changes in the middle ear secondary to reactions in the nose.Upper respiratory tract allergy may cause some intrinsic and extrinsic mechanical obstruction in patients who have ABSTRACT Background: Allergic rhinitis (AR) is a common condition affecting 20-30% of the population. This condition affects not only the nose but also the sinuses and ears in many ways. Many studies are there worldwide implicating AR as a cause of serous otitis media. But only few studies have actually studied the tympanic membrane (TM) changes observed in patients with allergic rhinitis. The aim of this study is to document the TM changes observed in patients with AR and to correlate them with the duration of symptoms and also influence of prior treatment of AR on the TM changes observed. Methods: A total of 111 patients and so 222 ears were studied. A detailed history of the duration of symptoms and any prior treatment for AR was recorded. The TM changes seen were classified and recorded. The duration of disease and treatment were taken as grouping variables and the tympanic membrane changes were ranked and used as testing variable. The results were statistically analyzed using non-parametric test, Kruskal -Wallis test. Results: There was no statistically significant correlation between duration of AR and the TM changes observed. However there was a significantly less number of patients with TM retraction observed in the patients who had taken prior treatment compared to those patients who had taken no prior treatment. Conclusions: It is concluded that institution of early treatment may prevent development of Eustachian tube dysfunction and TM changes in patients with AR.

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“…Previous studies indicated that age, gender, race, genetic factors, low socioeconomic status, breastfeeding, allergic diseases, and chronic sinusitis were associated with otitis media 6,7,15,16 . Several studies of them reported that allergic rhinitis was a risk factor affecting the occurrence of otitis media 17 .…”

Section: Introductionmentioning

confidence: 99%

The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children

Byeon

2019

Sci Rep

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Although many studies have reported that allergic rhinitis is an independent risk factor highly related to otitis media in children, there is still lack of epidemiological studies on demographics. The objective of this study was to identify if allergic rhinitis was an independent risk factor for otitis media in children aged between 7 and 12 years by using the nationwide survey data representing the local population of South Korea. This is a secondary study based on the ENT examination data (eg. acute otitis media, otitis media with effusion, chronic otitis media). The subjects of this study were 472 children (248 male and 224 female) who completed the Korea National Health and Nutrition Examination Survey 2015. The presence of otitis media was examined by otolaryngologists using tympanometric measurements, audiometric measurements, and otoscopic examination. Allergic rhinitis was diagnosed by Korean-version of International Study of Asthma and Allergies in Childhood, a total serum immunoglobulin E test, an allergen-specific immunoglobulin E test, a blood eosinophil test, an eosinophil cationic protein test, a nasal cytology for eosinophils test, a skin reaction test, and an antigen simultaneous test. Confounding factors included age, gender, the levels of income for households, and household composition. The relationship between allergic rhinitis and otitis media was analyzed by a complex sample logistic regression analysis and the odds ratio and 95% confidence interval were presented. The results of a complex sample design logistic regression revealed that allergic rhinitis in children was significantly associated with otitis media (p < 0.05). Even after adjusting all confounding factors, children with allergic rhinitis had twice significantly higher risk of otitis (OR = 2.04; 95% CI: 1.30–3.18) than children without allergic rhinitis. This epidemiologic study confirmed the independent relationship between pediatric allergic rhinitis and otitis media. In the future, longitudinal study will be needed to verify causality of allergic rhinitis and otitis media.

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Age: An effect modifier of the association between allergic rhinitis and Otitis media with effusion

Abstract: 2c. Laryngoscope, 126:1687-1692, 2016.

Cited by 33 publications

References 32 publications

Altered Middle Ear Microbiome in Children With Chronic Otitis Media With Effusion and Respiratory Illnesses

Altered Middle Ear Microbiome in Children With Chronic Otitis Media With Effusion and Respiratory Illnesses

Observational study of tympanic membrane changes in allergic rhinitis

The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children

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