Age-adjusted cut-off values of lipid accumulation product (LAP) for predicting hypertension

Abstract

Among the many factors considered relevant to hypertension, obesity and metabolic disturbances play an important role in the development of this pathology. Therefore, lipid accumulation product (LAP), an index of visceral adiposity, is a simple and effective indicator of hypertension risk. To date, the reference and cut-off values for LAP have not been defined. The aim of the study was to determine the age-adjusted optimal cut-off values of LAP for the prediction of hypertension risk. This cross-sectional case–control study comprised 1960 subjects ranging from 20 to 64 years of age. The participants underwent anthropometric tests, blood pressure measurements, questionnaire surveys and laboratory examinations. The cut-off values of LAP were determined using receiver operating characteristic (ROC) curve analysis. According to our study results, LAP values in healthy subjects increased with age, whereas there was no effect of age on LAP values in patients with hypertension. These two findings determine the presence of age-adjusted cut-off values of LAP for diagnosing hypertension. Increasing age is associated with an increase in the cut-off values of LAP to detect hypertension. In conclusion, hypertension risk should be estimated using the age-adjusted cut-off values of LAP; otherwise, the risk of hypertension might be overestimated or underestimated.

Integral metabolic indices as markers of increased arterial stiffness in young and middle-aged individuals with hypertension and other cardiovascular risk factors

“…Вопрос о референтных значениях LAP остается открытым, однако в работах Каневой А. М. и Бойко Е. Р. (2021г) предложены пороговые значения для предсказания наличия АГ у российских пациентов различных возрастных групп [18]. Полученные авторами значения LAP для возрастной группы пациентов, включенных в нашу работу (35-49 лет), составили 27 для женщин и 36,4 для мужчин [18].…”

“…(2021г) предложены пороговые значения для предсказания наличия АГ у российских пациентов различных возрастных групп [18]. Полученные авторами значения LAP для возрастной группы пациентов, включенных в нашу работу (35-49 лет), составили 27 для женщин и 36,4 для мужчин [18]. Рассчитанное в настоящем исследовании пороговое значение служит для предсказания наличия повышенной артериальной жесткости без учета полового фактора, что является определенным ограничением исследования и требует дальнейшего изучения.…”

MAFLD/NAFLD Biopsy-Free Scoring Systems for Hepatic Steatosis, NASH, and Fibrosis Diagnosis

“…Certain BFSSs underperformed in validation studies, such as the BAAT score ( 168 ), Nice model ( 59 , 60 ), OW liver test ( 61 , 62 ), NASH score ( 63 ), CHeK model ( 165 ), or GlycoNASH test ( 64 ), making them unsuitable alternatives for MAFLD/NAFLD diagnosis; thus, they were consequently excluded from the scrutiny of this review. Comprehensive studies on the effects of age, BMI, obesity, and the prevalence rates in different populations ( 101 , 140 , 148 , 169 ) are required to determine the role of current and future BFSSs in MAFLD/NAFLD diagnosis. Other non-invasive alternatives have been proposed recently, such as cell-free DNA, which has been found in extracellular vesicles in the serum of patients with fatty liver, and have yielded promising results ( 170 ).…”